Molecular Pathways in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension is a multifactorial, chronic disease process that leads to pulmonary arterial endothelial dysfunction and smooth muscular hypertrophy, resulting in impaired pliability and hemodynamics of the pulmonary vascular system, and consequent right ventricular dysfunction. Exi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/17/10001 |
| _version_ | 1797495027828523008 |
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| author | Aangi J. Shah Mounica Vorla Dinesh K. Kalra |
| author_facet | Aangi J. Shah Mounica Vorla Dinesh K. Kalra |
| author_sort | Aangi J. Shah |
| collection | DOAJ |
| description | Pulmonary arterial hypertension is a multifactorial, chronic disease process that leads to pulmonary arterial endothelial dysfunction and smooth muscular hypertrophy, resulting in impaired pliability and hemodynamics of the pulmonary vascular system, and consequent right ventricular dysfunction. Existing treatments target limited pathways with only modest improvement in disease morbidity, and little or no improvement in mortality. Ongoing research has focused on the molecular basis of pulmonary arterial hypertension and is going to be important in the discovery of new treatments and genetic pathways involved. This review focuses on the molecular pathogenesis of pulmonary arterial hypertension. |
| first_indexed | 2024-03-10T01:42:39Z |
| format | Article |
| id | doaj.art-c922c7d51923478d84ff8ff52fc34608 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:42:39Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c922c7d51923478d84ff8ff52fc346082023-11-23T13:21:08ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-09-0123171000110.3390/ijms231710001Molecular Pathways in Pulmonary Arterial HypertensionAangi J. Shah0Mounica Vorla1Dinesh K. Kalra2Department of Internal Medicine, School of Medicine, University of Louisville, Louisville, KY 40202, USADivision of Cardiology, School of Medicine, University of Louisville, Louisville, KY 40202, USADivision of Cardiology, School of Medicine, University of Louisville, Louisville, KY 40202, USAPulmonary arterial hypertension is a multifactorial, chronic disease process that leads to pulmonary arterial endothelial dysfunction and smooth muscular hypertrophy, resulting in impaired pliability and hemodynamics of the pulmonary vascular system, and consequent right ventricular dysfunction. Existing treatments target limited pathways with only modest improvement in disease morbidity, and little or no improvement in mortality. Ongoing research has focused on the molecular basis of pulmonary arterial hypertension and is going to be important in the discovery of new treatments and genetic pathways involved. This review focuses on the molecular pathogenesis of pulmonary arterial hypertension.https://www.mdpi.com/1422-0067/23/17/10001pulmonary arterial hypertensionmolecular pathogenesisclassificationpathobiology |
| spellingShingle | Aangi J. Shah Mounica Vorla Dinesh K. Kalra Molecular Pathways in Pulmonary Arterial Hypertension International Journal of Molecular Sciences pulmonary arterial hypertension molecular pathogenesis classification pathobiology |
| title | Molecular Pathways in Pulmonary Arterial Hypertension |
| title_full | Molecular Pathways in Pulmonary Arterial Hypertension |
| title_fullStr | Molecular Pathways in Pulmonary Arterial Hypertension |
| title_full_unstemmed | Molecular Pathways in Pulmonary Arterial Hypertension |
| title_short | Molecular Pathways in Pulmonary Arterial Hypertension |
| title_sort | molecular pathways in pulmonary arterial hypertension |
| topic | pulmonary arterial hypertension molecular pathogenesis classification pathobiology |
| url | https://www.mdpi.com/1422-0067/23/17/10001 |
| work_keys_str_mv | AT aangijshah molecularpathwaysinpulmonaryarterialhypertension AT mounicavorla molecularpathwaysinpulmonaryarterialhypertension AT dineshkkalra molecularpathwaysinpulmonaryarterialhypertension |