Pharmacological and Structure-Activity Relationship Evaluation of 4-aryl-1-Diphenylacetyl(thio)semicarbazides

Pharmacological and Structure-Activity Relationship Evaluation of 4-aryl-1-Diphenylacetyl(thio)semicarbazides

This article describes the synthesis of six 4-aryl-(thio)semicarbazides (series a and b) linked with diphenylacetyl moiety along with their pharmacological evaluation on the central nervous system in mice and computational studies, including conformational analysis and electrostatic properties. All...

Полное описание

Библиографические подробности
Главные авторы: Monika Wujec, Ewa Kędzierska, Edyta Kuśmierz, Tomasz Plech, Andrzej Wróbel, Agata Paneth, Jolanta Orzelska, Sylwia Fidecka, Piotr Paneth
Формат: Статья
Язык:English
Опубликовано: MDPI AG 2014-04-01
Серии:Molecules
Предметы:
(thio)semicarbazides
conformational analysis
electrostatic properties
CNS activity
analgesic activity
serotonergic activity
Online-ссылка:http://www.mdpi.com/1420-3049/19/4/4745

Internet

http://www.mdpi.com/1420-3049/19/4/4745

Схожие документы