Effects of L- and N-Type Ca Channel Blocker Cilnidipine on Changes in Heart Rate and QT Interval During Dialysis
Background/Aims: Hemodialysis patients have poor prognosis due to increased prevalence of cardiovascular diseases. Treatment to suppress increases in sympathetic nerve activity and QT prolongation may have the potential to reduce the occurrence of these events. The L/N-type Calcium (Ca) channel bloc...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2017-11-01
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| Series: | Kidney & Blood Pressure Research |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/485083 |
| _version_ | 1818849124074651648 |
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| author | Takeshi Iida Satoshi Morimoto Yoshifumi Amari Takashi Ando Atsuhiro Ichihara |
| author_facet | Takeshi Iida Satoshi Morimoto Yoshifumi Amari Takashi Ando Atsuhiro Ichihara |
| author_sort | Takeshi Iida |
| collection | DOAJ |
| description | Background/Aims: Hemodialysis patients have poor prognosis due to increased prevalence of cardiovascular diseases. Treatment to suppress increases in sympathetic nerve activity and QT prolongation may have the potential to reduce the occurrence of these events. The L/N-type Calcium (Ca) channel blocker cilnidipine has unique inhibitory action to inhibit sympathetic nerve activity and in a canine model ameliorates QT prolongation. In this study, we investigated whether cilnidipine has inhibitory effects on heart rate, an index of sympathetic nerve activity, and QT prolongation in patients undergoing dialysis. Methods: An L-type Ca channel blocker amlodipine was administered for 4 weeks followed by cilnidipine treatment for 4 weeks. On the last day of each period, heart rate and corrected QT interval were estimated and compared between the two periods. Results: Cilnidipine showed greater suppression of heart rate during dialysis than did amlodipine. The corrected QT interval in one dialysis session was significantly increased, and 3 of 17 patients showed prominent QT prolongation during administration of amlodipine but not cilnidipine. Conclusion: These data suggested that cilnidipine may inhibit increases in heart rate and QT interval. Cilnidipine may have beneficial effects in reducing cardiovascular events, resulting from increased sympathetic nerve activity and lethal arrhythmias in hemodialysis patients. |
| first_indexed | 2024-12-19T06:28:15Z |
| format | Article |
| id | doaj.art-c924be8926314d00aeebe300de7c3d7e |
| institution | Directory Open Access Journal |
| issn | 1420-4096 1423-0143 |
| language | English |
| last_indexed | 2024-12-19T06:28:15Z |
| publishDate | 2017-11-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Kidney & Blood Pressure Research |
| spelling | doaj.art-c924be8926314d00aeebe300de7c3d7e2022-12-21T20:32:28ZengKarger PublishersKidney & Blood Pressure Research1420-40961423-01432017-11-0142593394110.1159/000485083485083Effects of L- and N-Type Ca Channel Blocker Cilnidipine on Changes in Heart Rate and QT Interval During DialysisTakeshi IidaSatoshi MorimotoYoshifumi AmariTakashi AndoAtsuhiro IchiharaBackground/Aims: Hemodialysis patients have poor prognosis due to increased prevalence of cardiovascular diseases. Treatment to suppress increases in sympathetic nerve activity and QT prolongation may have the potential to reduce the occurrence of these events. The L/N-type Calcium (Ca) channel blocker cilnidipine has unique inhibitory action to inhibit sympathetic nerve activity and in a canine model ameliorates QT prolongation. In this study, we investigated whether cilnidipine has inhibitory effects on heart rate, an index of sympathetic nerve activity, and QT prolongation in patients undergoing dialysis. Methods: An L-type Ca channel blocker amlodipine was administered for 4 weeks followed by cilnidipine treatment for 4 weeks. On the last day of each period, heart rate and corrected QT interval were estimated and compared between the two periods. Results: Cilnidipine showed greater suppression of heart rate during dialysis than did amlodipine. The corrected QT interval in one dialysis session was significantly increased, and 3 of 17 patients showed prominent QT prolongation during administration of amlodipine but not cilnidipine. Conclusion: These data suggested that cilnidipine may inhibit increases in heart rate and QT interval. Cilnidipine may have beneficial effects in reducing cardiovascular events, resulting from increased sympathetic nerve activity and lethal arrhythmias in hemodialysis patients.https://www.karger.com/Article/FullText/485083Cardiovascular eventHemodialysisHypertensionSudden deathSympathetic nerve activity |
| spellingShingle | Takeshi Iida Satoshi Morimoto Yoshifumi Amari Takashi Ando Atsuhiro Ichihara Effects of L- and N-Type Ca Channel Blocker Cilnidipine on Changes in Heart Rate and QT Interval During Dialysis Kidney & Blood Pressure Research Cardiovascular event Hemodialysis Hypertension Sudden death Sympathetic nerve activity |
| title | Effects of L- and N-Type Ca Channel Blocker Cilnidipine on Changes in Heart Rate and QT Interval During Dialysis |
| title_full | Effects of L- and N-Type Ca Channel Blocker Cilnidipine on Changes in Heart Rate and QT Interval During Dialysis |
| title_fullStr | Effects of L- and N-Type Ca Channel Blocker Cilnidipine on Changes in Heart Rate and QT Interval During Dialysis |
| title_full_unstemmed | Effects of L- and N-Type Ca Channel Blocker Cilnidipine on Changes in Heart Rate and QT Interval During Dialysis |
| title_short | Effects of L- and N-Type Ca Channel Blocker Cilnidipine on Changes in Heart Rate and QT Interval During Dialysis |
| title_sort | effects of l and n type ca channel blocker cilnidipine on changes in heart rate and qt interval during dialysis |
| topic | Cardiovascular event Hemodialysis Hypertension Sudden death Sympathetic nerve activity |
| url | https://www.karger.com/Article/FullText/485083 |
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