Regression of leukemia cutis with gilteritinib in a case of FLT3-positive acute myeloid leukemia
Acute myeloid leukemia is a hematological disease with a poor prognosis. Blast cells that characterize the disease are generally present in the bone marrow, but they can sometimes be located in different organs. This rare event can occur at diagnosis or at relapse, together or not with bone marrow i...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Current Problems in Cancer: Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666621922000485 |
| _version_ | 1811183478133227520 |
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| author | Andrea Duminuco Francesco Di Raimondo Elisa Mauro Cinzia Maugeri Marina Silvia Parisi Giuseppe A.M. Palumbo Paolo F. Fiumara Bruno Garibaldi Calogero Vetro |
| author_facet | Andrea Duminuco Francesco Di Raimondo Elisa Mauro Cinzia Maugeri Marina Silvia Parisi Giuseppe A.M. Palumbo Paolo F. Fiumara Bruno Garibaldi Calogero Vetro |
| author_sort | Andrea Duminuco |
| collection | DOAJ |
| description | Acute myeloid leukemia is a hematological disease with a poor prognosis. Blast cells that characterize the disease are generally present in the bone marrow, but they can sometimes be located in different organs. This rare event can occur at diagnosis or at relapse, together or not with bone marrow involvement, and worsens prognosis and management. Despite this, the introduction into clinical practice of newly approved drugs directed towards molecular targets and approved for acute myeloid leukemia will pave the way for new treatment approaches facing this rare disease. In this paper, we present a case of a patient with acute myeloid leukemia with extramedullary manifestations involving the cutis and responding to FLT3-directed target therapy. |
| first_indexed | 2024-04-11T09:47:52Z |
| format | Article |
| id | doaj.art-c926eea2a2e54dff8c356a8562a86a2a |
| institution | Directory Open Access Journal |
| issn | 2666-6219 |
| language | English |
| last_indexed | 2024-04-11T09:47:52Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Problems in Cancer: Case Reports |
| spelling | doaj.art-c926eea2a2e54dff8c356a8562a86a2a2022-12-22T04:30:55ZengElsevierCurrent Problems in Cancer: Case Reports2666-62192022-09-017100184Regression of leukemia cutis with gilteritinib in a case of FLT3-positive acute myeloid leukemiaAndrea Duminuco0Francesco Di Raimondo1Elisa Mauro2Cinzia Maugeri3Marina Silvia Parisi4Giuseppe A.M. Palumbo5Paolo F. Fiumara6Bruno Garibaldi7Calogero Vetro8Division of Hematology with BMT, A.O.U. Policlinico “G.Rodolico-San Marco”, Via S. Sofia 78, Catania, Italy; Corresponding author.Division of Hematology with BMT, A.O.U. Policlinico “G.Rodolico-San Marco”, Via S. Sofia 78, Catania, ItalyDivision of Hematology with BMT, A.O.U. Policlinico “G.Rodolico-San Marco”, Via S. Sofia 78, Catania, ItalyDivision of Hematology with BMT, A.O.U. Policlinico “G.Rodolico-San Marco”, Via S. Sofia 78, Catania, ItalyDivision of Hematology with BMT, A.O.U. Policlinico “G.Rodolico-San Marco”, Via S. Sofia 78, Catania, ItalyDivision of Hematology with BMT, A.O.U. Policlinico “G.Rodolico-San Marco”, Via S. Sofia 78, Catania, Italy; Department of Scienze Mediche Chirurgiche e Tecnologie Avanzate “G.F. Ingrassia”, University of Catania, Catania, ItalyDivision of Hematology with BMT, A.O.U. Policlinico “G.Rodolico-San Marco”, Via S. Sofia 78, Catania, ItalyDivision of Hematology with BMT, A.O.U. Policlinico “G.Rodolico-San Marco”, Via S. Sofia 78, Catania, ItalyDivision of Hematology with BMT, A.O.U. Policlinico “G.Rodolico-San Marco”, Via S. Sofia 78, Catania, ItalyAcute myeloid leukemia is a hematological disease with a poor prognosis. Blast cells that characterize the disease are generally present in the bone marrow, but they can sometimes be located in different organs. This rare event can occur at diagnosis or at relapse, together or not with bone marrow involvement, and worsens prognosis and management. Despite this, the introduction into clinical practice of newly approved drugs directed towards molecular targets and approved for acute myeloid leukemia will pave the way for new treatment approaches facing this rare disease. In this paper, we present a case of a patient with acute myeloid leukemia with extramedullary manifestations involving the cutis and responding to FLT3-directed target therapy.http://www.sciencedirect.com/science/article/pii/S2666621922000485AMLMyeloid sarcomaFLT3FLT3-inhibitorsExtramedullary AML |
| spellingShingle | Andrea Duminuco Francesco Di Raimondo Elisa Mauro Cinzia Maugeri Marina Silvia Parisi Giuseppe A.M. Palumbo Paolo F. Fiumara Bruno Garibaldi Calogero Vetro Regression of leukemia cutis with gilteritinib in a case of FLT3-positive acute myeloid leukemia Current Problems in Cancer: Case Reports AML Myeloid sarcoma FLT3 FLT3-inhibitors Extramedullary AML |
| title | Regression of leukemia cutis with gilteritinib in a case of FLT3-positive acute myeloid leukemia |
| title_full | Regression of leukemia cutis with gilteritinib in a case of FLT3-positive acute myeloid leukemia |
| title_fullStr | Regression of leukemia cutis with gilteritinib in a case of FLT3-positive acute myeloid leukemia |
| title_full_unstemmed | Regression of leukemia cutis with gilteritinib in a case of FLT3-positive acute myeloid leukemia |
| title_short | Regression of leukemia cutis with gilteritinib in a case of FLT3-positive acute myeloid leukemia |
| title_sort | regression of leukemia cutis with gilteritinib in a case of flt3 positive acute myeloid leukemia |
| topic | AML Myeloid sarcoma FLT3 FLT3-inhibitors Extramedullary AML |
| url | http://www.sciencedirect.com/science/article/pii/S2666621922000485 |
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