Use of Levetiracetam in Epileptic Dogs with Chronic Kidney Disease: A Retrospective Study
In human medicine, doses of levetiracetam (LEV) are individualized for patients with epilepsy, depending on the status of the patient’s renal function. However, there are not reports on the individualized dosing of LEV for small animals. The aim of this study is to investigate whether a dose adjustm...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/8/11/263 |
| _version_ | 1797508270698528768 |
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| author | So-Yeon Gim Woo-Jin Song Hwa-Young Youn |
| author_facet | So-Yeon Gim Woo-Jin Song Hwa-Young Youn |
| author_sort | So-Yeon Gim |
| collection | DOAJ |
| description | In human medicine, doses of levetiracetam (LEV) are individualized for patients with epilepsy, depending on the status of the patient’s renal function. However, there are not reports on the individualized dosing of LEV for small animals. The aim of this study is to investigate whether a dose adjustment of LEV is needed in dogs with chronic kidney disease (CKD). Patient databases were searched, and 37 dogs with seizures or epilepsy were retrospectively included in this study. Based on pre-existing CKD, patients were divided into a CKD group (<i>n</i> = 20) and a non-CKD group (<i>n</i> = 17). We collected kidney panels before and after LEV treatment. Side-effects were monitored for 1 month after the start of LEV administration. In the CKD group, more dogs developed adverse effects (85%) than in the non-CKD group (52.94%). After LEV administration, an increase in blood urea nitrogen and/or serum creatinine was more often reported in the CKD group than it was in the non-CKD group. Our data indicate that in dogs with seizures or epilepsy with pre-existing CKD, an LEV dose-adjustment is needed. During LEV treatment, CKD patients should be monitored for side-effects and may require laboratory evaluation of renal function. |
| first_indexed | 2024-03-10T04:59:32Z |
| format | Article |
| id | doaj.art-c927cdfb5bae4d15bb24208d745b37db |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-10T04:59:32Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-c927cdfb5bae4d15bb24208d745b37db2023-11-23T01:54:26ZengMDPI AGVeterinary Sciences2306-73812021-11-0181126310.3390/vetsci8110263Use of Levetiracetam in Epileptic Dogs with Chronic Kidney Disease: A Retrospective StudySo-Yeon Gim0Woo-Jin Song1Hwa-Young Youn2Laboratory of Veterinary Internal Medicine, Department of Veterinary Medical Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, KoreaLaboratory of Veterinary Internal Medicine and Research Institute for Veterinary Science, College of Veterinary Medicine, Jeju National University, Jeju 63243, KoreaLaboratory of Veterinary Internal Medicine, Department of Veterinary Medical Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, KoreaIn human medicine, doses of levetiracetam (LEV) are individualized for patients with epilepsy, depending on the status of the patient’s renal function. However, there are not reports on the individualized dosing of LEV for small animals. The aim of this study is to investigate whether a dose adjustment of LEV is needed in dogs with chronic kidney disease (CKD). Patient databases were searched, and 37 dogs with seizures or epilepsy were retrospectively included in this study. Based on pre-existing CKD, patients were divided into a CKD group (<i>n</i> = 20) and a non-CKD group (<i>n</i> = 17). We collected kidney panels before and after LEV treatment. Side-effects were monitored for 1 month after the start of LEV administration. In the CKD group, more dogs developed adverse effects (85%) than in the non-CKD group (52.94%). After LEV administration, an increase in blood urea nitrogen and/or serum creatinine was more often reported in the CKD group than it was in the non-CKD group. Our data indicate that in dogs with seizures or epilepsy with pre-existing CKD, an LEV dose-adjustment is needed. During LEV treatment, CKD patients should be monitored for side-effects and may require laboratory evaluation of renal function.https://www.mdpi.com/2306-7381/8/11/263adverse effectchronic kidney diseasedogsepilepsylevetiracetam |
| spellingShingle | So-Yeon Gim Woo-Jin Song Hwa-Young Youn Use of Levetiracetam in Epileptic Dogs with Chronic Kidney Disease: A Retrospective Study Veterinary Sciences adverse effect chronic kidney disease dogs epilepsy levetiracetam |
| title | Use of Levetiracetam in Epileptic Dogs with Chronic Kidney Disease: A Retrospective Study |
| title_full | Use of Levetiracetam in Epileptic Dogs with Chronic Kidney Disease: A Retrospective Study |
| title_fullStr | Use of Levetiracetam in Epileptic Dogs with Chronic Kidney Disease: A Retrospective Study |
| title_full_unstemmed | Use of Levetiracetam in Epileptic Dogs with Chronic Kidney Disease: A Retrospective Study |
| title_short | Use of Levetiracetam in Epileptic Dogs with Chronic Kidney Disease: A Retrospective Study |
| title_sort | use of levetiracetam in epileptic dogs with chronic kidney disease a retrospective study |
| topic | adverse effect chronic kidney disease dogs epilepsy levetiracetam |
| url | https://www.mdpi.com/2306-7381/8/11/263 |
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