Alterations in UPR Signaling by Methylmercury Trigger Neuronal Cell Death in the Mouse Brain

Alterations in UPR Signaling by Methylmercury Trigger Neuronal Cell Death in the Mouse Brain

Methylmercury (MeHg), an environmental toxicant, induces neuronal cell death and injures specific areas of the brain. MeHg is known to induce oxidative and endoplasmic reticulum (ER) stress. The unfolded protein response (UPR) pathway has a dual nature in that it regulates and protects cells from an...

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Bibliographic Details
Main Authors: Ryosuke Nomura, Nobumasa Takasugi, Hideki Hiraoka, Yuta Iijima, Takao Iwawaki, Yoshito Kumagai, Masatake Fujimura, Takashi Uehara
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
methylmercury
neuronal cell death
endoplasmic reticulum stress
unfolded protein response
ERAI system
Online Access:https://www.mdpi.com/1422-0067/23/23/15412

Internet

https://www.mdpi.com/1422-0067/23/23/15412

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