Alterations in UPR Signaling by Methylmercury Trigger Neuronal Cell Death in the Mouse Brain
Methylmercury (MeHg), an environmental toxicant, induces neuronal cell death and injures specific areas of the brain. MeHg is known to induce oxidative and endoplasmic reticulum (ER) stress. The unfolded protein response (UPR) pathway has a dual nature in that it regulates and protects cells from an...
Main Authors: | Ryosuke Nomura, Nobumasa Takasugi, Hideki Hiraoka, Yuta Iijima, Takao Iwawaki, Yoshito Kumagai, Masatake Fujimura, Takashi Uehara |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-12-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/23/23/15412 |
Similar Items
-
Exploring the molecular mechanisms underlie the endoplasmic reticulum stress-mediated methylmercury-induced neuronal developmental damage
by: Jingjing Pan, et al.
Published: (2022-10-01) -
A functional link between the co-translational protein translocation pathway and the UPR
by: Rachel Plumb, et al.
Published: (2015-05-01) -
The Function of KDEL Receptors as UPR Genes in Disease
by: Emily S. Wires, et al.
Published: (2021-05-01) -
The Role of the UPR Pathway in the Pathophysiology and Treatment of Bipolar Disorder
by: Mahmoud Suliman, et al.
Published: (2021-08-01) -
Prx1 Regulates Thapsigargin-Mediated UPR Activation and Apoptosis
by: Eun-Kyung Kim, et al.
Published: (2022-11-01)