Combined treatment of miltefosine and paromomycin delays the onset of experimental drug resistance in Leishmania infantum.

Combined treatment of miltefosine and paromomycin delays the onset of experimental drug resistance in Leishmania infantum.

BACKGROUND:Since miltefosine monotherapy against visceral leishmaniasis (VL) caused by Leishmania donovani has been discontinued in the Indian subcontinent due to an increase in the number of treatment failures, single dose liposomal amphotericin B is now advocated as a treatment option of choice. P...

Full description

Bibliographic Details
Main Authors:	Sarah Hendrickx, Magali Van den Kerkhof, Dorien Mabille, Paul Cos, Peter Delputte, Louis Maes, Guy Caljon
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2017-05-01
Series:	PLoS Neglected Tropical Diseases
Online Access:	http://europepmc.org/articles/PMC5444850?pdf=render

Similar Items

Impact of clinically acquired miltefosine resistance by Leishmania infantum on mouse and sand fly infection
by: Lieselotte Van Bockstal, et al.
Published: (2020-08-01)

Impaired development of a miltefosine-resistant Leishmania infantum strain in the sand fly vectors Phlebotomus perniciosus and Lutzomyia longipalpis
by: Lieselotte Van Bockstal, et al.
Published: (2019-12-01)

Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes.
by: Annelies Mondelaers, et al.
Published: (2016-01-01)

Comparative Fitness of a Parent Leishmania donovani Clinical Isolate and Its Experimentally Derived Paromomycin-Resistant Strain.
by: Sarah Hendrickx, et al.
Published: (2015-01-01)

Phenotypic adaptations of Leishmania donovani to recurrent miltefosine exposure and impact on sand fly infection
by: Sarah Hendrickx, et al.
Published: (2020-02-01)

Mitochondrial Proteomics of Antimony and Miltefosine Resistant Leishmania infantum
by: Isabel M. Vincent, et al.
Published: (2015-10-01)

Miltefosine induces metacaspase and PARP genes expression in Leishmania infantum
by: Shahram Khademvatan, et al.
Published: (2011-09-01)

Miltefosine induces metacaspase and PARP genes expression in Leishmania infantum
by: Shahram Khademvatan, et al.

Induction of Apoptosis by Miltefosine in Iranian Strain of Leishmania infantum Promastigotes
by: S Khademvatan, et al.
Published: (2009-06-01)

Induction of Apoptosis by Miltefosine in Iranian Strain of Leishmania infantum Promastigotes
by: R Hadighi, et al.
Published: (2009-05-01)

The effect of the sugar metabolism on Leishmania infantum promastigotes inside the gut of Lutzomyia longipalpis: A sweet relationship?
by: Sarah Hendrickx, et al.
Published: (2022-04-01)

Experimental Selection of Paromomycin Resistance in <i>Leishmania donovani</i> Amastigotes Induces Variable Genomic Polymorphisms
by: Sarah Hendrickx, et al.
Published: (2021-07-01)

Increased Leishmania infantum resistance to miltefosine and amphotericin B after treatment of a dog with miltefosine and allopurinol
by: Gustavo Gonçalves, et al.
Published: (2021-12-01)

In Vitro and Ex Vivo Synergistic Effect of Pyrvinium Pamoate Combined with Miltefosine and Paromomycin against <i>Leishmania</i>
by: Estela Melcón-Fernández, et al.
Published: (2024-01-01)

Use of miltefosine to treat canine visceral leishmaniasis caused by Leishmania infantum in Brazil
by: Fabio dos Santos Nogueira, et al.
Published: (2019-02-01)

Therapeutic success and failure in using miltefosine to treat dogs naturally infected with Leishmania infantum
by: Gustavo Gonçalves, et al.
Published: (2024-02-01)

In-Depth Quantitative Proteomics Characterization of In Vitro Selected Miltefosine Resistance in <i>Leishmania infantum</i>
by: Leonardo Saboia-Vahia, et al.
Published: (2022-03-01)

Effect of Clindamycin on Intestinal Microbiome and Miltefosine Pharmacology in Hamsters Infected with <i>Leishmania infantum</i>
by: Ana Isabel Olías-Molero, et al.
Published: (2023-02-01)

3′Nucleotidase/nuclease is required for Leishmania infantum clinical isolate susceptibility to miltefosineResearch in context
by: Juliana B.T. Carnielli, et al.
Published: (2022-12-01)

Generation of luciferase-expressing Leishmania infantum chagasi and assessment of miltefosine efficacy in infected hamsters through bioimaging.
by: Juliana Q Reimão, et al.
Published: (2015-02-01)

A Leishmania infantum genetic marker associated with miltefosine treatment failure for visceral leishmaniasisResearch in context
by: Juliana B.T. Carnielli, et al.
Published: (2018-10-01)

In-depth comparison of cell-based methodological approaches to determine drug susceptibility of visceral Leishmania isolates.
by: Sarah Hendrickx, et al.
Published: (2019-12-01)

Paromomycin affects translation and vesicle-mediated trafficking as revealed by proteomics of paromomycin -susceptible -resistant Leishmania donovani.
by: Bhavna Chawla, et al.
Published: (2011-01-01)

Safety and efficacy of short course combination regimens with AmBisome, miltefosine and paromomycin for the treatment of visceral leishmaniasis (VL) in Bangladesh.
by: Ridwanur Rahman, et al.
Published: (2017-05-01)

Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin
by: Moran Shalev-Benami, et al.
Published: (2017-11-01)

Leishmania Resistance to Miltefosine Associated with Genetic Marker
by: Sandrine Cojean, et al.
Published: (2012-04-01)

In vitro and in vivo pharmacodynamics of three novel antileishmanial lead series
by: M. Van den Kerkhof, et al.
Published: (2018-04-01)

Identification of Resistance Determinants for a Promising Antileishmanial Oxaborole Series
by: Magali Van den Kerkhof, et al.
Published: (2021-06-01)

Ascorbic acid reduces the genetic damage caused by miltefosine (hexadecylphosphocholine) in animals infected by Leishmania (Leishamnia) infantum without decreasing its antileishmanial activity
by: Patrícia Valéria Castelo-Branco, et al.
Published: (2019-04-01)

Complex cutaneous infection by Leishmania mexicana treated with miltefosine
by: Rachel L. Sadowsky, BA, et al.
Published: (2022-11-01)

Fitness and Phenotypic Characterization of Miltefosine-Resistant Leishmania major.
by: Kimbra G Turner, et al.
Published: (2015-01-01)

Paromomycin sulphate
by: 982 SIRIM

4E Interacting Protein as a Potential Novel Drug Target for Nucleoside Analogues in <i>Trypanosoma brucei</i>
by: Dorien Mabille, et al.
Published: (2021-04-01)

Final comments on an interesting taxonomic dilemma: Leishmania infantum versus Leishmania infantum chagasi
by: Filipe Dantas-Torres
Published: (2006-12-01)

Experimental induction of paromomycin resistance in antimony-resistant strains of L. donovani: outcome dependent on in vitro selection protocol.
by: Sarah Hendrickx, et al.
Published: (2012-01-01)

In Vitro Susceptibility to Miltefosine of <i>Leishmania infantum</i> (syn. <i>L.</i> <i>chagasi</i>) Isolates from Different Geographical Areas in Brazil
by: Caroline Ricce Espada, et al.
Published: (2021-06-01)

Positive kidney profile of dogs with Leishmania sp. and treated with miltefosine
by: Danillo Brenno de Assis Torres, et al.
Published: (2024-03-01)

Miltefosine induces programmed cell death in Leishmania amazonensis promastigotes
by: Fernanda de Aquino Marinho, et al.
Published: (2011-06-01)

Genes and Chromosomes of Leishmania infantum
by: Jose María Requena, et al.
Published: (1997-11-01)

Transcriptome profiling identifies genes/pathways associated with experimental resistance to paromomycin in Leishmania donovani
by: Aditya Verma, et al.
Published: (2017-12-01)