Ethanol Induces Secretion of Proinflammatory Extracellular Vesicles That Inhibit Adult Hippocampal Neurogenesis Through G9a/GLP-Epigenetic Signaling

Ethanol Induces Secretion of Proinflammatory Extracellular Vesicles That Inhibit Adult Hippocampal Neurogenesis Through G9a/GLP-Epigenetic Signaling

Adult hippocampal neurogenesis (AHN) is involved in learning and memory as well as regulation of mood. Binge ethanol reduces AHN, though the mechanism is unknown. Microglia in the neurogenic niche are important regulators of AHN, and ethanol promotes proinflammatory microglia activation. We recently...

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Bibliographic Details
Main Authors: Jian Zou, T. Jordan Walter, Alexandra Barnett, Aaron Rohlman, Fulton T. Crews, Leon G. Coleman
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
alcohol
inflammation
neurogenesis
microglia
epigenetics
G9a
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.866073/full

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