Recent Advances in the Application Peptide and Peptoid in Diagnosis Biomarkers of Alzheimer’s Disease in Blood
Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases with irreversible damage of the brain and a continuous pathophysiological process. Early detection and accurate diagnosis are essential for the early intervention of AD. Precise detection of blood biomarkers related to AD...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2021.778955/full |
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| author | Yuxin Guo Yuxin Guo Zhiyuan Hu Zhiyuan Hu Zhiyuan Hu Zhiyuan Hu Zihua Wang |
| author_facet | Yuxin Guo Yuxin Guo Zhiyuan Hu Zhiyuan Hu Zhiyuan Hu Zhiyuan Hu Zihua Wang |
| author_sort | Yuxin Guo |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases with irreversible damage of the brain and a continuous pathophysiological process. Early detection and accurate diagnosis are essential for the early intervention of AD. Precise detection of blood biomarkers related to AD could provide a shortcut to identifying early-stage patients before symptoms. In recent years, targeting peptides or peptoids have been chosen as recognition elements in nano-sensors or fluorescence detection to increase the targeting specificity, while peptide-based probes were also developed considering their specific advantages. Peptide-based sensors and probes have been developed according to different strategies, such as natural receptors, high-throughput screening, or artificial design for AD detection. This review will briefly summarize the recent developments and trends of AD diagnosis platforms based on peptide and peptoid as recognition elements and provide insights into the application of peptide and peptoid with different sources and characteristics in the diagnosis of AD biomarkers. |
| first_indexed | 2024-12-24T01:40:50Z |
| format | Article |
| id | doaj.art-c92e66321b5d46b79ecb3dc19b5fdfa4 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-12-24T01:40:50Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-c92e66321b5d46b79ecb3dc19b5fdfa42022-12-21T17:22:03ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992021-12-011410.3389/fnmol.2021.778955778955Recent Advances in the Application Peptide and Peptoid in Diagnosis Biomarkers of Alzheimer’s Disease in BloodYuxin Guo0Yuxin Guo1Zhiyuan Hu2Zhiyuan Hu3Zhiyuan Hu4Zhiyuan Hu5Zihua Wang6CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaCAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, ChinaFujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, ChinaSchool of Nanoscience and Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing, ChinaSchool of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, ChinaFujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, ChinaAlzheimer’s disease (AD) is one of the most common neurodegenerative diseases with irreversible damage of the brain and a continuous pathophysiological process. Early detection and accurate diagnosis are essential for the early intervention of AD. Precise detection of blood biomarkers related to AD could provide a shortcut to identifying early-stage patients before symptoms. In recent years, targeting peptides or peptoids have been chosen as recognition elements in nano-sensors or fluorescence detection to increase the targeting specificity, while peptide-based probes were also developed considering their specific advantages. Peptide-based sensors and probes have been developed according to different strategies, such as natural receptors, high-throughput screening, or artificial design for AD detection. This review will briefly summarize the recent developments and trends of AD diagnosis platforms based on peptide and peptoid as recognition elements and provide insights into the application of peptide and peptoid with different sources and characteristics in the diagnosis of AD biomarkers.https://www.frontiersin.org/articles/10.3389/fnmol.2021.778955/fullAlzheimer’s diseaseblood biomarkersdiagnosispeptidepeptoid |
| spellingShingle | Yuxin Guo Yuxin Guo Zhiyuan Hu Zhiyuan Hu Zhiyuan Hu Zhiyuan Hu Zihua Wang Recent Advances in the Application Peptide and Peptoid in Diagnosis Biomarkers of Alzheimer’s Disease in Blood Frontiers in Molecular Neuroscience Alzheimer’s disease blood biomarkers diagnosis peptide peptoid |
| title | Recent Advances in the Application Peptide and Peptoid in Diagnosis Biomarkers of Alzheimer’s Disease in Blood |
| title_full | Recent Advances in the Application Peptide and Peptoid in Diagnosis Biomarkers of Alzheimer’s Disease in Blood |
| title_fullStr | Recent Advances in the Application Peptide and Peptoid in Diagnosis Biomarkers of Alzheimer’s Disease in Blood |
| title_full_unstemmed | Recent Advances in the Application Peptide and Peptoid in Diagnosis Biomarkers of Alzheimer’s Disease in Blood |
| title_short | Recent Advances in the Application Peptide and Peptoid in Diagnosis Biomarkers of Alzheimer’s Disease in Blood |
| title_sort | recent advances in the application peptide and peptoid in diagnosis biomarkers of alzheimer s disease in blood |
| topic | Alzheimer’s disease blood biomarkers diagnosis peptide peptoid |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2021.778955/full |
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