The Role of Exosomes in the Crosstalk between Adipocytes and Liver Cancer Cells
Exosomes are membrane-bound extracellular vesicles (EVs) that transport bioactive materials between cells and organs. The cargo delivered by exosomes can alter a wide range of cellular responses in recipient cells and play an important pathophysiological role in human cancers. In hepatocellular carc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/9/1988 |
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| author | Leslimar Rios-Colon Elena Arthur Suryakant Niture Qi Qi John T. Moore Deepak Kumar |
| author_facet | Leslimar Rios-Colon Elena Arthur Suryakant Niture Qi Qi John T. Moore Deepak Kumar |
| author_sort | Leslimar Rios-Colon |
| collection | DOAJ |
| description | Exosomes are membrane-bound extracellular vesicles (EVs) that transport bioactive materials between cells and organs. The cargo delivered by exosomes can alter a wide range of cellular responses in recipient cells and play an important pathophysiological role in human cancers. In hepatocellular carcinoma (HCC), for example, adipocyte- and tumor-secreted factors contained in exosomes contribute to the creation of a chronic inflammatory state, which contributes to disease progression. The exosome-mediated crosstalk between adipocytes and liver cancer cells is a key aspect of a dynamic tumor microenvironment. In this review, we summarize the role of increased adiposity and the role of adipocyte-derived exosomes (AdExos) and HCC-derived exosomes (HCCExos) in the modulation of HCC progression. We also discuss recent advances regarding how malignant cells interact with the surrounding adipose tissue and employ exosomes to promote a more aggressive phenotype. |
| first_indexed | 2024-03-10T16:44:15Z |
| format | Article |
| id | doaj.art-c92e89032f9645188da6cb0a88c15712 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T16:44:15Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-c92e89032f9645188da6cb0a88c157122023-11-20T11:48:38ZengMDPI AGCells2073-44092020-08-0199198810.3390/cells9091988The Role of Exosomes in the Crosstalk between Adipocytes and Liver Cancer CellsLeslimar Rios-Colon0Elena Arthur1Suryakant Niture2Qi Qi3John T. Moore4Deepak Kumar5Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USAJulius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USAJulius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USAJulius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USAJulius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USAJulius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USAExosomes are membrane-bound extracellular vesicles (EVs) that transport bioactive materials between cells and organs. The cargo delivered by exosomes can alter a wide range of cellular responses in recipient cells and play an important pathophysiological role in human cancers. In hepatocellular carcinoma (HCC), for example, adipocyte- and tumor-secreted factors contained in exosomes contribute to the creation of a chronic inflammatory state, which contributes to disease progression. The exosome-mediated crosstalk between adipocytes and liver cancer cells is a key aspect of a dynamic tumor microenvironment. In this review, we summarize the role of increased adiposity and the role of adipocyte-derived exosomes (AdExos) and HCC-derived exosomes (HCCExos) in the modulation of HCC progression. We also discuss recent advances regarding how malignant cells interact with the surrounding adipose tissue and employ exosomes to promote a more aggressive phenotype.https://www.mdpi.com/2073-4409/9/9/1988hepatocellular carcinomaobesityadipocytesexosomesadipocyte exosomesexosomal cargo |
| spellingShingle | Leslimar Rios-Colon Elena Arthur Suryakant Niture Qi Qi John T. Moore Deepak Kumar The Role of Exosomes in the Crosstalk between Adipocytes and Liver Cancer Cells Cells hepatocellular carcinoma obesity adipocytes exosomes adipocyte exosomes exosomal cargo |
| title | The Role of Exosomes in the Crosstalk between Adipocytes and Liver Cancer Cells |
| title_full | The Role of Exosomes in the Crosstalk between Adipocytes and Liver Cancer Cells |
| title_fullStr | The Role of Exosomes in the Crosstalk between Adipocytes and Liver Cancer Cells |
| title_full_unstemmed | The Role of Exosomes in the Crosstalk between Adipocytes and Liver Cancer Cells |
| title_short | The Role of Exosomes in the Crosstalk between Adipocytes and Liver Cancer Cells |
| title_sort | role of exosomes in the crosstalk between adipocytes and liver cancer cells |
| topic | hepatocellular carcinoma obesity adipocytes exosomes adipocyte exosomes exosomal cargo |
| url | https://www.mdpi.com/2073-4409/9/9/1988 |
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