Small Cell Neuroendocrine of the Head and Neck: A Rare Presentation and Review of the Literature
Head and neck tumors account for roughly 3% of malignancies in the United States and about 90% of these tumors are squamous cell cancers. Neuroendocrine neoplasms arise from neural crest cells and are commonly found in the gastrointestinal tract. Neuroendocrine neoplasms arising from the head and ne...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-09-01
|
| Series: | Journal of Investigative Medicine High Impact Case Reports |
| Online Access: | https://doi.org/10.1177/23247096221127792 |
| _version_ | 1828387531399364608 |
|---|---|
| author | Stephanie Niforatos MD Michael Sandhu MD Mansi Kallem MD Serenella Serinelli MD, PhD Christopher Curtiss MD Komal Akhtar MD |
| author_facet | Stephanie Niforatos MD Michael Sandhu MD Mansi Kallem MD Serenella Serinelli MD, PhD Christopher Curtiss MD Komal Akhtar MD |
| author_sort | Stephanie Niforatos MD |
| collection | DOAJ |
| description | Head and neck tumors account for roughly 3% of malignancies in the United States and about 90% of these tumors are squamous cell cancers. Neuroendocrine neoplasms arise from neural crest cells and are commonly found in the gastrointestinal tract. Neuroendocrine neoplasms arising from the head and neck tend to be rare. In this article, we present a rare case of human papilloma virus–associated poorly differentiated small cell neuroendocrine carcinoma (NEC). Our patient was a 62-year-old African American man who presented with worsening left-sided neck pain and swelling that started 3 months prior to presentation, associated with an unintentional 20-pound weight loss over 6 months, hoarseness in his voice, in addition to dysphagia and odynophagia. Biopsy of left-sided tongue mass revealed poorly differentiated small cell NEC that was positive for HPV (E6/E7) RNA in situ hybridization. Patient was found to have metastatic disease at the time of diagnosis and given the aggressive nature of small cell NECs and the patient’s symptomatic burden, chemotherapy with cisplatin and etoposide was initiated in the hospital. The patient was subsequently discharged from the hospital and is continuing treatment outpatient with cisplatin, etoposide, and atezolizumab. |
| first_indexed | 2024-12-10T05:54:51Z |
| format | Article |
| id | doaj.art-c92f524992534d85a13a854c74f677fc |
| institution | Directory Open Access Journal |
| issn | 2324-7096 |
| language | English |
| last_indexed | 2024-12-10T05:54:51Z |
| publishDate | 2022-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Investigative Medicine High Impact Case Reports |
| spelling | doaj.art-c92f524992534d85a13a854c74f677fc2022-12-22T01:59:57ZengSAGE PublishingJournal of Investigative Medicine High Impact Case Reports2324-70962022-09-011010.1177/23247096221127792Small Cell Neuroendocrine of the Head and Neck: A Rare Presentation and Review of the LiteratureStephanie Niforatos MD0Michael Sandhu MD1Mansi Kallem MD2Serenella Serinelli MD, PhD3Christopher Curtiss MD4Komal Akhtar MD5State University of New York Upstate Medical University, Syracuse, USAState University of New York Upstate Medical University, Syracuse, USAState University of New York Upstate Medical University, Syracuse, USAState University of New York Upstate Medical University, Syracuse, USAState University of New York Upstate Medical University, Syracuse, USAState University of New York Upstate Medical University, Syracuse, USAHead and neck tumors account for roughly 3% of malignancies in the United States and about 90% of these tumors are squamous cell cancers. Neuroendocrine neoplasms arise from neural crest cells and are commonly found in the gastrointestinal tract. Neuroendocrine neoplasms arising from the head and neck tend to be rare. In this article, we present a rare case of human papilloma virus–associated poorly differentiated small cell neuroendocrine carcinoma (NEC). Our patient was a 62-year-old African American man who presented with worsening left-sided neck pain and swelling that started 3 months prior to presentation, associated with an unintentional 20-pound weight loss over 6 months, hoarseness in his voice, in addition to dysphagia and odynophagia. Biopsy of left-sided tongue mass revealed poorly differentiated small cell NEC that was positive for HPV (E6/E7) RNA in situ hybridization. Patient was found to have metastatic disease at the time of diagnosis and given the aggressive nature of small cell NECs and the patient’s symptomatic burden, chemotherapy with cisplatin and etoposide was initiated in the hospital. The patient was subsequently discharged from the hospital and is continuing treatment outpatient with cisplatin, etoposide, and atezolizumab.https://doi.org/10.1177/23247096221127792 |
| spellingShingle | Stephanie Niforatos MD Michael Sandhu MD Mansi Kallem MD Serenella Serinelli MD, PhD Christopher Curtiss MD Komal Akhtar MD Small Cell Neuroendocrine of the Head and Neck: A Rare Presentation and Review of the Literature Journal of Investigative Medicine High Impact Case Reports |
| title | Small Cell Neuroendocrine of the Head and Neck: A Rare Presentation and Review of the Literature |
| title_full | Small Cell Neuroendocrine of the Head and Neck: A Rare Presentation and Review of the Literature |
| title_fullStr | Small Cell Neuroendocrine of the Head and Neck: A Rare Presentation and Review of the Literature |
| title_full_unstemmed | Small Cell Neuroendocrine of the Head and Neck: A Rare Presentation and Review of the Literature |
| title_short | Small Cell Neuroendocrine of the Head and Neck: A Rare Presentation and Review of the Literature |
| title_sort | small cell neuroendocrine of the head and neck a rare presentation and review of the literature |
| url | https://doi.org/10.1177/23247096221127792 |
| work_keys_str_mv | AT stephanieniforatosmd smallcellneuroendocrineoftheheadandneckararepresentationandreviewoftheliterature AT michaelsandhumd smallcellneuroendocrineoftheheadandneckararepresentationandreviewoftheliterature AT mansikallemmd smallcellneuroendocrineoftheheadandneckararepresentationandreviewoftheliterature AT serenellaserinellimdphd smallcellneuroendocrineoftheheadandneckararepresentationandreviewoftheliterature AT christophercurtissmd smallcellneuroendocrineoftheheadandneckararepresentationandreviewoftheliterature AT komalakhtarmd smallcellneuroendocrineoftheheadandneckararepresentationandreviewoftheliterature |