Alpha-synuclein as a biomarker of Parkinson’s disease
Parkinsons disease (PD) is a common neurodegenerative disorder.Toxic aggregation of a small presynaptic protein alpha-synucleinis considered to be the main step in the pathogenesis of PD.Today there are no suitable diagnostic tests based on biochemicalinvestigation of such readily accessible tissues...
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| Format: | Article |
| Language: | English |
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Research Center of Neurology
2017-02-01
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| Series: | Анналы клинической и экспериментальной неврологии |
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| Online Access: | https://annaly-nevrologii.com/journal/pathID/article/viewFile/289/195 |
| _version_ | 1818240600919506944 |
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| author | S. N. Pchelina |
| author_facet | S. N. Pchelina |
| author_sort | S. N. Pchelina |
| collection | DOAJ |
| description | Parkinsons disease (PD) is a common neurodegenerative disorder.Toxic aggregation of a small presynaptic protein alpha-synucleinis considered to be the main step in the pathogenesis of PD.Today there are no suitable diagnostic tests based on biochemicalinvestigation of such readily accessible tissues as blood andcerebrospinal fluid (CSF). A search for PD biomarkers aimed atdiagnosis and monitoring of the disease remains very actual. Assuggested in several studies, the use of the peripheral alphasynucleinlevel might be a prognostic marker for PD, but untilnow this question remains open. Evaluation of blood and CSFalpha-synuclein levels in patients with PD compared with agematchedcontrols provided conflicting results. Specific detectionand quantification of oligomeric forms of alpha-synuclein incombination with the improvement of imaging techniques maybe considered as most perspective direction. |
| first_indexed | 2024-12-12T13:16:02Z |
| format | Article |
| id | doaj.art-c93197ca003a4df4ac2152ab51b6bd72 |
| institution | Directory Open Access Journal |
| issn | 2075-5473 2409-2533 |
| language | English |
| last_indexed | 2024-12-12T13:16:02Z |
| publishDate | 2017-02-01 |
| publisher | Research Center of Neurology |
| record_format | Article |
| series | Анналы клинической и экспериментальной неврологии |
| spelling | doaj.art-c93197ca003a4df4ac2152ab51b6bd722022-12-22T00:23:24ZengResearch Center of NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-25332017-02-0154465110.17816/psaic289196Alpha-synuclein as a biomarker of Parkinson’s diseaseS. N. Pchelina0St. Petersburg State Medical University named after I.P. Pavlov (St. Petersburg)Parkinsons disease (PD) is a common neurodegenerative disorder.Toxic aggregation of a small presynaptic protein alpha-synucleinis considered to be the main step in the pathogenesis of PD.Today there are no suitable diagnostic tests based on biochemicalinvestigation of such readily accessible tissues as blood andcerebrospinal fluid (CSF). A search for PD biomarkers aimed atdiagnosis and monitoring of the disease remains very actual. Assuggested in several studies, the use of the peripheral alphasynucleinlevel might be a prognostic marker for PD, but untilnow this question remains open. Evaluation of blood and CSFalpha-synuclein levels in patients with PD compared with agematchedcontrols provided conflicting results. Specific detectionand quantification of oligomeric forms of alpha-synuclein incombination with the improvement of imaging techniques maybe considered as most perspective direction.https://annaly-nevrologii.com/journal/pathID/article/viewFile/289/195parkinson’s diseasebiomarkersalpha-synuclein |
| spellingShingle | S. N. Pchelina Alpha-synuclein as a biomarker of Parkinson’s disease Анналы клинической и экспериментальной неврологии parkinson’s disease biomarkers alpha-synuclein |
| title | Alpha-synuclein as a biomarker of Parkinson’s disease |
| title_full | Alpha-synuclein as a biomarker of Parkinson’s disease |
| title_fullStr | Alpha-synuclein as a biomarker of Parkinson’s disease |
| title_full_unstemmed | Alpha-synuclein as a biomarker of Parkinson’s disease |
| title_short | Alpha-synuclein as a biomarker of Parkinson’s disease |
| title_sort | alpha synuclein as a biomarker of parkinson s disease |
| topic | parkinson’s disease biomarkers alpha-synuclein |
| url | https://annaly-nevrologii.com/journal/pathID/article/viewFile/289/195 |
| work_keys_str_mv | AT snpchelina alphasynucleinasabiomarkerofparkinsonsdisease |