Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children
Little is known about whether second-hand smoke (SHS) exposure affects tuberculosis (TB). Here, we investigate the association of cigarette smoke exposure with active TB and latent TB infection (LTBI) in children, analyzing Interferon-Gamma Release Assays’ (IGRAs) performance and cytokine immune res...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-04-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/11/7/2000 |
| _version_ | 1797438756497653760 |
|---|---|
| author | Neus Altet Irene Latorre María Ángeles Jiménez-Fuentes Antoni Soriano-Arandes Raquel Villar-Hernández Celia Milà Pablo Rodríguez-Fernández Beatriz Muriel-Moreno Patricia Comella-del-Barrio Pere Godoy Joan-Pau Millet Maria Luiza de Souza-Galvão Carlos A. Jiménez-Ruiz Jose Domínguez on behalf of PII Smoking SEPAR Working Group |
| author_facet | Neus Altet Irene Latorre María Ángeles Jiménez-Fuentes Antoni Soriano-Arandes Raquel Villar-Hernández Celia Milà Pablo Rodríguez-Fernández Beatriz Muriel-Moreno Patricia Comella-del-Barrio Pere Godoy Joan-Pau Millet Maria Luiza de Souza-Galvão Carlos A. Jiménez-Ruiz Jose Domínguez on behalf of PII Smoking SEPAR Working Group |
| author_sort | Neus Altet |
| collection | DOAJ |
| description | Little is known about whether second-hand smoke (SHS) exposure affects tuberculosis (TB). Here, we investigate the association of cigarette smoke exposure with active TB and latent TB infection (LTBI) in children, analyzing Interferon-Gamma Release Assays’ (IGRAs) performance and cytokine immune responses. A total of 616 children from contact-tracing studies were included and classified regarding their smoking habits [unexposed, SHS, or smokers]. Risk factors for positive IGRAs, LTBI, and active TB were defined. GM-CSF, IFN-γ, IL-2, IL-5, IL-10, IL-13, IL-22, IL-17, TNF-α, IL-1RA and IP-10 cytokines were detected in a subgroup of patients. Being SHS exposed was associated with a positive IGRA [aOR (95% CI): 8.7 (5.9–12.8)] and was a main factor related with LTBI [aOR (95% CI): 7.57 (4.79–11.94)] and active TB [aOR (95% CI): 3.40 (1.45–7.98)]. Moreover, IGRAs’ sensitivity was reduced in active TB patients exposed to tobacco. IL-22, GM-CSF, IL-5, TNF-α, IP-10, and IL-13 were less secreted in LTBI children exposed to SHS. In conclusion, SHS is associated with LTBI and active TB in children. In addition, false-negative IGRAs obtained on active TB patients exposed to SHS, together with the decrease of specific cytokines released, suggest that tobacco may alter the immune response. |
| first_indexed | 2024-03-09T11:42:52Z |
| format | Article |
| id | doaj.art-c935a4e5952647cabfa3448842f48517 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T11:42:52Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-c935a4e5952647cabfa3448842f485172023-11-30T23:29:51ZengMDPI AGJournal of Clinical Medicine2077-03832022-04-01117200010.3390/jcm11072000Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in ChildrenNeus Altet0Irene Latorre1María Ángeles Jiménez-Fuentes2Antoni Soriano-Arandes3Raquel Villar-Hernández4Celia Milà5Pablo Rodríguez-Fernández6Beatriz Muriel-Moreno7Patricia Comella-del-Barrio8Pere Godoy9Joan-Pau Millet10Maria Luiza de Souza-Galvão11Carlos A. Jiménez-Ruiz12Jose Domínguez13on behalf of PII Smoking SEPAR Working GroupUnitat de Tuberculosi Vall d’Hebron-Drassanes, Hospital Universitari Vall d’Hebron, 08001 Barcelona, SpainInstitut d’Investigació Germans Trias i Pujol, CIBER Enfermedades Respiratorias, Universitat Autònoma de Barcelona, 08916 Badalona, SpainUnitat de Tuberculosi Vall d’Hebron-Drassanes, Hospital Universitari Vall d’Hebron, 08001 Barcelona, SpainUnitat de Tuberculosi Vall d’Hebron-Drassanes, Hospital Universitari Vall d’Hebron, 08001 Barcelona, SpainInstitut d’Investigació Germans Trias i Pujol, CIBER Enfermedades Respiratorias, Universitat Autònoma de Barcelona, 08916 Badalona, SpainUnitat de Tuberculosi Vall d’Hebron-Drassanes, Hospital Universitari Vall d’Hebron, 08001 Barcelona, SpainInstitut d’Investigació Germans Trias i Pujol, CIBER Enfermedades Respiratorias, Universitat Autònoma de Barcelona, 08916 Badalona, SpainInstitut d’Investigació Germans Trias i Pujol, CIBER Enfermedades Respiratorias, Universitat Autònoma de Barcelona, 08916 Badalona, SpainInstitut d’Investigació Germans Trias i Pujol, CIBER Enfermedades Respiratorias, Universitat Autònoma de Barcelona, 08916 Badalona, SpainDepartament de Salut, Generalitat de Catalunya, 08028 Barcelona, SpainServeis Clínics, Unitat Clínica de Tractament Directament Observat de la Tuberculosi, 08022 Barcelona, SpainUnitat de Tuberculosi Vall d’Hebron-Drassanes, Hospital Universitari Vall d’Hebron, 08001 Barcelona, SpainUnidad de Tabaquismo de la Comunidad Autónoma de Madrid, 28015 Madrid, SpainInstitut d’Investigació Germans Trias i Pujol, CIBER Enfermedades Respiratorias, Universitat Autònoma de Barcelona, 08916 Badalona, SpainLittle is known about whether second-hand smoke (SHS) exposure affects tuberculosis (TB). Here, we investigate the association of cigarette smoke exposure with active TB and latent TB infection (LTBI) in children, analyzing Interferon-Gamma Release Assays’ (IGRAs) performance and cytokine immune responses. A total of 616 children from contact-tracing studies were included and classified regarding their smoking habits [unexposed, SHS, or smokers]. Risk factors for positive IGRAs, LTBI, and active TB were defined. GM-CSF, IFN-γ, IL-2, IL-5, IL-10, IL-13, IL-22, IL-17, TNF-α, IL-1RA and IP-10 cytokines were detected in a subgroup of patients. Being SHS exposed was associated with a positive IGRA [aOR (95% CI): 8.7 (5.9–12.8)] and was a main factor related with LTBI [aOR (95% CI): 7.57 (4.79–11.94)] and active TB [aOR (95% CI): 3.40 (1.45–7.98)]. Moreover, IGRAs’ sensitivity was reduced in active TB patients exposed to tobacco. IL-22, GM-CSF, IL-5, TNF-α, IP-10, and IL-13 were less secreted in LTBI children exposed to SHS. In conclusion, SHS is associated with LTBI and active TB in children. In addition, false-negative IGRAs obtained on active TB patients exposed to SHS, together with the decrease of specific cytokines released, suggest that tobacco may alter the immune response.https://www.mdpi.com/2077-0383/11/7/2000<i>Mycobacterium tuberculosis</i>cigarette smokingpassive smokingchildimmunology |
| spellingShingle | Neus Altet Irene Latorre María Ángeles Jiménez-Fuentes Antoni Soriano-Arandes Raquel Villar-Hernández Celia Milà Pablo Rodríguez-Fernández Beatriz Muriel-Moreno Patricia Comella-del-Barrio Pere Godoy Joan-Pau Millet Maria Luiza de Souza-Galvão Carlos A. Jiménez-Ruiz Jose Domínguez on behalf of PII Smoking SEPAR Working Group Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children Journal of Clinical Medicine <i>Mycobacterium tuberculosis</i> cigarette smoking passive smoking child immunology |
| title | Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children |
| title_full | Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children |
| title_fullStr | Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children |
| title_full_unstemmed | Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children |
| title_short | Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children |
| title_sort | tobacco smoking and second hand smoke exposure impact on tuberculosis in children |
| topic | <i>Mycobacterium tuberculosis</i> cigarette smoking passive smoking child immunology |
| url | https://www.mdpi.com/2077-0383/11/7/2000 |
| work_keys_str_mv | AT neusaltet tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren AT irenelatorre tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren AT mariaangelesjimenezfuentes tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren AT antonisorianoarandes tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren AT raquelvillarhernandez tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren AT celiamila tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren AT pablorodriguezfernandez tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren AT beatrizmurielmoreno tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren AT patriciacomelladelbarrio tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren AT peregodoy tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren AT joanpaumillet tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren AT marialuizadesouzagalvao tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren AT carlosajimenezruiz tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren AT josedominguez tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren AT onbehalfofpiismokingseparworkinggroup tobaccosmokingandsecondhandsmokeexposureimpactontuberculosisinchildren |