Firing up the Tumor Microenvironment with Nanoparticle-Based Therapies
Therapies mobilizing host immunity against cancer cells have profoundly improved prognosis of cancer patients. However, efficacy of immunotherapies depends on local immune conditions. The “cold” tumor, which is characterized by lacking inflamed T cells, is insensitive to immunotherapy. Current strat...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/13/9/1338 |
| _version_ | 1797517684618821632 |
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| author | Yunfeng Pan Xueru Song Yue Wang Jia Wei |
| author_facet | Yunfeng Pan Xueru Song Yue Wang Jia Wei |
| author_sort | Yunfeng Pan |
| collection | DOAJ |
| description | Therapies mobilizing host immunity against cancer cells have profoundly improved prognosis of cancer patients. However, efficacy of immunotherapies depends on local immune conditions. The “cold” tumor, which is characterized by lacking inflamed T cells, is insensitive to immunotherapy. Current strategies of improving the “cold” tumor microenvironment are far from satisfying. Nanoparticle-based therapies provide novel inspiration in firing up the tumor microenvironment. In this review, we presented progress and limitations of conventional immunotherapies. Then, we enumerate advantages of nanoparticle-based therapies in remodeling the “cold” tumor microenvironment. Finally, we discuss the prospect of nanoparticle-based therapies in clinical application. |
| first_indexed | 2024-03-10T07:19:38Z |
| format | Article |
| id | doaj.art-c93625070b344482a4af6de2b0ffa80d |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T07:19:38Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-c93625070b344482a4af6de2b0ffa80d2023-11-22T14:46:07ZengMDPI AGPharmaceutics1999-49232021-08-01139133810.3390/pharmaceutics13091338Firing up the Tumor Microenvironment with Nanoparticle-Based TherapiesYunfeng Pan0Xueru Song1Yue Wang2Jia Wei3The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing 210008, ChinaThe Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing 210008, ChinaThe Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing 210008, ChinaThe Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing 210008, ChinaTherapies mobilizing host immunity against cancer cells have profoundly improved prognosis of cancer patients. However, efficacy of immunotherapies depends on local immune conditions. The “cold” tumor, which is characterized by lacking inflamed T cells, is insensitive to immunotherapy. Current strategies of improving the “cold” tumor microenvironment are far from satisfying. Nanoparticle-based therapies provide novel inspiration in firing up the tumor microenvironment. In this review, we presented progress and limitations of conventional immunotherapies. Then, we enumerate advantages of nanoparticle-based therapies in remodeling the “cold” tumor microenvironment. Finally, we discuss the prospect of nanoparticle-based therapies in clinical application.https://www.mdpi.com/1999-4923/13/9/1338nanoparticleimmunotherapytumor microenvironmentcancer vaccineadoptive cell therapy |
| spellingShingle | Yunfeng Pan Xueru Song Yue Wang Jia Wei Firing up the Tumor Microenvironment with Nanoparticle-Based Therapies Pharmaceutics nanoparticle immunotherapy tumor microenvironment cancer vaccine adoptive cell therapy |
| title | Firing up the Tumor Microenvironment with Nanoparticle-Based Therapies |
| title_full | Firing up the Tumor Microenvironment with Nanoparticle-Based Therapies |
| title_fullStr | Firing up the Tumor Microenvironment with Nanoparticle-Based Therapies |
| title_full_unstemmed | Firing up the Tumor Microenvironment with Nanoparticle-Based Therapies |
| title_short | Firing up the Tumor Microenvironment with Nanoparticle-Based Therapies |
| title_sort | firing up the tumor microenvironment with nanoparticle based therapies |
| topic | nanoparticle immunotherapy tumor microenvironment cancer vaccine adoptive cell therapy |
| url | https://www.mdpi.com/1999-4923/13/9/1338 |
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