The clinical significance of circulating glucose-regulated protein 78, Caspase-3, and C/EBP homologous protein levels in patients with heart failure
Background and aims: The destruction of endoplasmic reticulum (ER) homeostasis leads to heart failure (HF), which further aggravates ER stress. Limited data are available on the levels of ER stress markers in HF patients in clinical practice. This study aimed to determine the clinical significance o...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023006436 |
| _version_ | 1811161785553649664 |
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| author | Xuecheng Zhao Da-Qi Zhang Rongjing Song Rong Wang Guoqiang Zhang |
| author_facet | Xuecheng Zhao Da-Qi Zhang Rongjing Song Rong Wang Guoqiang Zhang |
| author_sort | Xuecheng Zhao |
| collection | DOAJ |
| description | Background and aims: The destruction of endoplasmic reticulum (ER) homeostasis leads to heart failure (HF), which further aggravates ER stress. Limited data are available on the levels of ER stress markers in HF patients in clinical practice. This study aimed to determine the clinical significance of the ER stress markers, glucose-regulated protein 78 (GRP78), Caspase-3, and C/EBP homologous protein (CHOP), in predicting HF and its severity. Materials and methods: A total of 62 patients with HF and 44 healthy controls were enrolled in the study, and all participants were followed-up for 2 years. Results: Serum GRP78, Caspase-3, and CHOP levels were significantly higher in patients with HF than those in healthy controls. The level of GRP78 increased with the severity of HF. GRP78 levels were negatively correlated with left ventricular ejection fraction, and positively correlated with N-terminal B-type natriuretic peptide, D-dimer, and lactic acid. Serum GRP78 and Caspase-3 levels showed moderate predictive values for HF patients. Conclusion: ER stress markers, GRP78 and Caspase-3, had a certain predictive value in HF and can be used as serum biomarkers for the diagnosis of HF. Additionally, GRP78 showed a certain predictive value in HF severity. |
| first_indexed | 2024-04-10T06:19:54Z |
| format | Article |
| id | doaj.art-c936c52c760845c99f562bfad865b0e1 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-10T06:19:54Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-c936c52c760845c99f562bfad865b0e12023-03-02T05:01:32ZengElsevierHeliyon2405-84402023-02-0192e13436The clinical significance of circulating glucose-regulated protein 78, Caspase-3, and C/EBP homologous protein levels in patients with heart failureXuecheng Zhao0Da-Qi Zhang1Rongjing Song2Rong Wang3Guoqiang Zhang4Department of Emergency Medicine, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Neurology, The First Affiliated Hospital of Hainan Medical University, Haikou, China; Corresponding author. Department of Neurology, the First Affiliated Hospital of Hainan Medical University, Longhua Road, Haikou City 570102, Hainan Province, China.Department of Pharmacy, Peking University People's Hospital, Beijing, ChinaSchool of Pharmaceutical Sciences, Hainan University, Haikou, ChinaDepartment of Emergency Medicine, China-Japan Friendship Hospital, Beijing, China; Corresponding author. Department of Emergency Medicine, China-Japan Friendship Hospital, 2 Yinghua Dongjie, Hepingli, Chaoyang District, Beijing, 100029, China.Background and aims: The destruction of endoplasmic reticulum (ER) homeostasis leads to heart failure (HF), which further aggravates ER stress. Limited data are available on the levels of ER stress markers in HF patients in clinical practice. This study aimed to determine the clinical significance of the ER stress markers, glucose-regulated protein 78 (GRP78), Caspase-3, and C/EBP homologous protein (CHOP), in predicting HF and its severity. Materials and methods: A total of 62 patients with HF and 44 healthy controls were enrolled in the study, and all participants were followed-up for 2 years. Results: Serum GRP78, Caspase-3, and CHOP levels were significantly higher in patients with HF than those in healthy controls. The level of GRP78 increased with the severity of HF. GRP78 levels were negatively correlated with left ventricular ejection fraction, and positively correlated with N-terminal B-type natriuretic peptide, D-dimer, and lactic acid. Serum GRP78 and Caspase-3 levels showed moderate predictive values for HF patients. Conclusion: ER stress markers, GRP78 and Caspase-3, had a certain predictive value in HF and can be used as serum biomarkers for the diagnosis of HF. Additionally, GRP78 showed a certain predictive value in HF severity.http://www.sciencedirect.com/science/article/pii/S2405844023006436Glucose-regulated protein 78Caspase-3C/EBP homologous ProteinHeart failure |
| spellingShingle | Xuecheng Zhao Da-Qi Zhang Rongjing Song Rong Wang Guoqiang Zhang The clinical significance of circulating glucose-regulated protein 78, Caspase-3, and C/EBP homologous protein levels in patients with heart failure Heliyon Glucose-regulated protein 78 Caspase-3 C/EBP homologous Protein Heart failure |
| title | The clinical significance of circulating glucose-regulated protein 78, Caspase-3, and C/EBP homologous protein levels in patients with heart failure |
| title_full | The clinical significance of circulating glucose-regulated protein 78, Caspase-3, and C/EBP homologous protein levels in patients with heart failure |
| title_fullStr | The clinical significance of circulating glucose-regulated protein 78, Caspase-3, and C/EBP homologous protein levels in patients with heart failure |
| title_full_unstemmed | The clinical significance of circulating glucose-regulated protein 78, Caspase-3, and C/EBP homologous protein levels in patients with heart failure |
| title_short | The clinical significance of circulating glucose-regulated protein 78, Caspase-3, and C/EBP homologous protein levels in patients with heart failure |
| title_sort | clinical significance of circulating glucose regulated protein 78 caspase 3 and c ebp homologous protein levels in patients with heart failure |
| topic | Glucose-regulated protein 78 Caspase-3 C/EBP homologous Protein Heart failure |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023006436 |
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