CAR-J cells for antibody discovery and lead optimization of TCR-like immunoglobulins

CAR-J cells for antibody discovery and lead optimization of TCR-like immunoglobulins

T-cell bispecific antibodies (TCBs) are a novel class of engineered immunoglobulins that unite monovalent binding to the T-cell receptor (TCR) CD3e chain and bivalent binding to tumor-associated antigens in order to recruit and activate T-cells for tumor cell killing. In vivo, T-cell activation is u...

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Bibliographic Details
Main Authors: Christian Jost, Diana Darowski, John Challier, Vesna Pulko, Lydia J Hanisch, Wei Xu, Ekkehard Mössner, Alexander Bujotzek, Stefan Klostermann, Pablo Umana, Roland E. Kontermann, Christian Klein
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:mAbs
Subjects:
Lead identification
T-cell receptor (TCR)
T-cell bispecific antibodies (TCB)
TCR-like antibodies (TCRL)
chimeric antigen receptor (CAR)
major histocompatibility complex (MHC)
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2020.1840709

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2020.1840709

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