Sheep recombinant IGF-1 promotes organ-specific growth in fetal sheep

Sheep recombinant IGF-1 promotes organ-specific growth in fetal sheep

IGF-1 is a critical fetal growth-promoting hormone. Experimental infusion of an IGF-1 analog, human recombinant LR3 IGF-1, into late gestation fetal sheep increased fetal organ growth and skeletal muscle myoblast proliferation. However, LR3 IGF-1 has a low affinity for IGF binding proteins (IGFBP),...

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Bibliographic Details
Main Authors: J Stremming, A White, A Donthi, DG Batt, B Hetrick, EI Chang, SR Wesolowski, MB Seefeldt, CE McCurdy, PJ Rozance, LD Brown
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Physiology
Subjects:
fetal growth
skeletal muscle
myoblast
IGF-1 signaling
IGF binding protein
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.954948/full

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