Multifunctional Graphene Oxide Nanodelivery Platform for Breast Cancer Treatment
Yousheng Mo,1,* Wei Liu,2,* Piaoxue Liu,2 Qiao Liu,3 Zhongyu Yuan,4 Qi Wang,2 Dongsheng Yuan,2 Xiao-Jia Chen,3 Tongkai Chen2 1The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, People’s Republic of China; 2Science and Technology Innovation...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-12-01
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| Series: | International Journal of Nanomedicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/multifunctional-graphene-oxide-nanodelivery-platform-for-breast-cancer-peer-reviewed-fulltext-article-IJN |
| _version_ | 1811197497712836608 |
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| author | Mo Y Liu W Liu P Liu Q Yuan Z Wang Q Yuan D Chen XJ Chen T |
| author_facet | Mo Y Liu W Liu P Liu Q Yuan Z Wang Q Yuan D Chen XJ Chen T |
| author_sort | Mo Y |
| collection | DOAJ |
| description | Yousheng Mo,1,* Wei Liu,2,* Piaoxue Liu,2 Qiao Liu,3 Zhongyu Yuan,4 Qi Wang,2 Dongsheng Yuan,2 Xiao-Jia Chen,3 Tongkai Chen2 1The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, People’s Republic of China; 2Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People’s Republic of China; 3State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, People’s Republic of China; 4Department of Medical Oncology, Sun Yat-Sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiao-Jia Chen; Tongkai Chen, Email xiaojiachen@um.edu.mo; chentongkai@gzucm.edu.cnBackground: Breast cancer (BC) has the highest global prevalence among all malignancies in women and the second highest prevalence in the overall population. Paclitaxel (PTX), a tricyclic diterpenoid, is effective against BC. However, its poor solubility in water and the allergenicity of its dissolution medium limited its clinical application.Methods: In this work, we established a multifunctional graphene oxide (GO) tumor-targeting drug delivery system using nanosized graphene oxide (nGO) modified with D-tocopherol polyethylene glycol succinate (TPGS) and arginine-glycine-aspartic acid (RGD) for PTX loading.Results: The obtained RGD-TPGS-nGO-PTX was 310.20± 19.86 nm in size; the polydispersity index (PDI) and zeta potential were 0.21± 0.020 and − 23.42 mV, respectively. The mean drug loading capacity of RGD-TPGS-nGO-PTX was 48.78%. RGD-TPGS-nGO-PTX showed satisfactory biocompatibility and biosafety and had no significant toxic effects on zebrafish embryos. Importantly, it exerted excellent cytotoxicity against MDA-MB-231 cells, reversed multi-drug resistance (MDR) in MCF-7/ADR cells, and showed significant anti-tumor efficacy in tumor-bearing nude mice.Conclusion: These findings strongly suggested that the multifunctional GO tumor-targeting drug delivery system RGD-TPGS-nGO-PTX could be used in clinical settings to improve PTX delivery, reverse MDR and increase the therapeutic efficacy of BC treatment.Keywords: breast cancer, paclitaxel, targeted delivery, multidrug resistance |
| first_indexed | 2024-04-12T01:14:50Z |
| format | Article |
| id | doaj.art-c93a870effb54bed9bec85922325e374 |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-04-12T01:14:50Z |
| publishDate | 2022-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-c93a870effb54bed9bec85922325e3742022-12-22T03:54:00ZengDove Medical PressInternational Journal of Nanomedicine1178-20132022-12-01Volume 176413642580377Multifunctional Graphene Oxide Nanodelivery Platform for Breast Cancer TreatmentMo YLiu WLiu PLiu QYuan ZWang QYuan DChen XJChen TYousheng Mo,1,* Wei Liu,2,* Piaoxue Liu,2 Qiao Liu,3 Zhongyu Yuan,4 Qi Wang,2 Dongsheng Yuan,2 Xiao-Jia Chen,3 Tongkai Chen2 1The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, People’s Republic of China; 2Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People’s Republic of China; 3State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, People’s Republic of China; 4Department of Medical Oncology, Sun Yat-Sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiao-Jia Chen; Tongkai Chen, Email xiaojiachen@um.edu.mo; chentongkai@gzucm.edu.cnBackground: Breast cancer (BC) has the highest global prevalence among all malignancies in women and the second highest prevalence in the overall population. Paclitaxel (PTX), a tricyclic diterpenoid, is effective against BC. However, its poor solubility in water and the allergenicity of its dissolution medium limited its clinical application.Methods: In this work, we established a multifunctional graphene oxide (GO) tumor-targeting drug delivery system using nanosized graphene oxide (nGO) modified with D-tocopherol polyethylene glycol succinate (TPGS) and arginine-glycine-aspartic acid (RGD) for PTX loading.Results: The obtained RGD-TPGS-nGO-PTX was 310.20± 19.86 nm in size; the polydispersity index (PDI) and zeta potential were 0.21± 0.020 and − 23.42 mV, respectively. The mean drug loading capacity of RGD-TPGS-nGO-PTX was 48.78%. RGD-TPGS-nGO-PTX showed satisfactory biocompatibility and biosafety and had no significant toxic effects on zebrafish embryos. Importantly, it exerted excellent cytotoxicity against MDA-MB-231 cells, reversed multi-drug resistance (MDR) in MCF-7/ADR cells, and showed significant anti-tumor efficacy in tumor-bearing nude mice.Conclusion: These findings strongly suggested that the multifunctional GO tumor-targeting drug delivery system RGD-TPGS-nGO-PTX could be used in clinical settings to improve PTX delivery, reverse MDR and increase the therapeutic efficacy of BC treatment.Keywords: breast cancer, paclitaxel, targeted delivery, multidrug resistancehttps://www.dovepress.com/multifunctional-graphene-oxide-nanodelivery-platform-for-breast-cancer-peer-reviewed-fulltext-article-IJNbreast cancerpaclitaxeltargeted deliverymultidrug resistance |
| spellingShingle | Mo Y Liu W Liu P Liu Q Yuan Z Wang Q Yuan D Chen XJ Chen T Multifunctional Graphene Oxide Nanodelivery Platform for Breast Cancer Treatment International Journal of Nanomedicine breast cancer paclitaxel targeted delivery multidrug resistance |
| title | Multifunctional Graphene Oxide Nanodelivery Platform for Breast Cancer Treatment |
| title_full | Multifunctional Graphene Oxide Nanodelivery Platform for Breast Cancer Treatment |
| title_fullStr | Multifunctional Graphene Oxide Nanodelivery Platform for Breast Cancer Treatment |
| title_full_unstemmed | Multifunctional Graphene Oxide Nanodelivery Platform for Breast Cancer Treatment |
| title_short | Multifunctional Graphene Oxide Nanodelivery Platform for Breast Cancer Treatment |
| title_sort | multifunctional graphene oxide nanodelivery platform for breast cancer treatment |
| topic | breast cancer paclitaxel targeted delivery multidrug resistance |
| url | https://www.dovepress.com/multifunctional-graphene-oxide-nanodelivery-platform-for-breast-cancer-peer-reviewed-fulltext-article-IJN |
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