SIMPLE AND SELECTIVE SPECTROPHOTOMETRIC ASSAY OF DIETHYLCARBAMAZINE CITRATE USING 2,3-DICHLORO-5,6-DICYANO-p-BENZOQUINONE AND 2,4-DINITRO PHENOL
Two simple, rapid and inexpensive spectrophotometric methods are described for the determination of diethylcarbamazine citrate (DEC) in bulk drug and formulations. The methods are based on the charge–transfer (CT) complexation reaction involving DEC as the n- donor and 2,3-dichloro-5,6-dicyano-p-ben...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2015-05-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422015000500715&lng=en&tlng=en |
| _version_ | 1818683452357083136 |
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| author | Nagaraju Swamy Kanakapura Basavaiah |
| author_facet | Nagaraju Swamy Kanakapura Basavaiah |
| author_sort | Nagaraju Swamy |
| collection | DOAJ |
| description | Two simple, rapid and inexpensive spectrophotometric methods are described for the determination of diethylcarbamazine citrate (DEC) in bulk drug and formulations. The methods are based on the charge–transfer (CT) complexation reaction involving DEC as the n- donor and 2,3-dichloro-5,6-dicyano-p-benzoquinone [DDQ] (method A) and 2,4-dinitro phenol [DNP] (method B) as π-acceptors in chloroform. The absorbance of CT complexes was measured at 480 nm for method A, and 420 nm for method B. Under optimum conditions, Beer’s law was obeyed over the concentration ranges 4-90 and 4-100 μg mL-1 for methods A and B, respectively. |
| first_indexed | 2024-12-17T10:34:58Z |
| format | Article |
| id | doaj.art-c93af52571f74e7dab01c3421bf7007b |
| institution | Directory Open Access Journal |
| issn | 1678-7064 |
| language | English |
| last_indexed | 2024-12-17T10:34:58Z |
| publishDate | 2015-05-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-c93af52571f74e7dab01c3421bf7007b2022-12-21T21:52:26ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642015-05-0138571572210.5935/0100-4042.20150061S0100-40422015000500715SIMPLE AND SELECTIVE SPECTROPHOTOMETRIC ASSAY OF DIETHYLCARBAMAZINE CITRATE USING 2,3-DICHLORO-5,6-DICYANO-p-BENZOQUINONE AND 2,4-DINITRO PHENOLNagaraju SwamyKanakapura BasavaiahTwo simple, rapid and inexpensive spectrophotometric methods are described for the determination of diethylcarbamazine citrate (DEC) in bulk drug and formulations. The methods are based on the charge–transfer (CT) complexation reaction involving DEC as the n- donor and 2,3-dichloro-5,6-dicyano-p-benzoquinone [DDQ] (method A) and 2,4-dinitro phenol [DNP] (method B) as π-acceptors in chloroform. The absorbance of CT complexes was measured at 480 nm for method A, and 420 nm for method B. Under optimum conditions, Beer’s law was obeyed over the concentration ranges 4-90 and 4-100 μg mL-1 for methods A and B, respectively.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422015000500715&lng=en&tlng=endiethylcarbamazine citratespectrophotometrycharge-transfer complexes |
| spellingShingle | Nagaraju Swamy Kanakapura Basavaiah SIMPLE AND SELECTIVE SPECTROPHOTOMETRIC ASSAY OF DIETHYLCARBAMAZINE CITRATE USING 2,3-DICHLORO-5,6-DICYANO-p-BENZOQUINONE AND 2,4-DINITRO PHENOL Química Nova diethylcarbamazine citrate spectrophotometry charge-transfer complexes |
| title | SIMPLE AND SELECTIVE SPECTROPHOTOMETRIC ASSAY OF DIETHYLCARBAMAZINE CITRATE USING 2,3-DICHLORO-5,6-DICYANO-p-BENZOQUINONE AND 2,4-DINITRO PHENOL |
| title_full | SIMPLE AND SELECTIVE SPECTROPHOTOMETRIC ASSAY OF DIETHYLCARBAMAZINE CITRATE USING 2,3-DICHLORO-5,6-DICYANO-p-BENZOQUINONE AND 2,4-DINITRO PHENOL |
| title_fullStr | SIMPLE AND SELECTIVE SPECTROPHOTOMETRIC ASSAY OF DIETHYLCARBAMAZINE CITRATE USING 2,3-DICHLORO-5,6-DICYANO-p-BENZOQUINONE AND 2,4-DINITRO PHENOL |
| title_full_unstemmed | SIMPLE AND SELECTIVE SPECTROPHOTOMETRIC ASSAY OF DIETHYLCARBAMAZINE CITRATE USING 2,3-DICHLORO-5,6-DICYANO-p-BENZOQUINONE AND 2,4-DINITRO PHENOL |
| title_short | SIMPLE AND SELECTIVE SPECTROPHOTOMETRIC ASSAY OF DIETHYLCARBAMAZINE CITRATE USING 2,3-DICHLORO-5,6-DICYANO-p-BENZOQUINONE AND 2,4-DINITRO PHENOL |
| title_sort | simple and selective spectrophotometric assay of diethylcarbamazine citrate using 2 3 dichloro 5 6 dicyano p benzoquinone and 2 4 dinitro phenol |
| topic | diethylcarbamazine citrate spectrophotometry charge-transfer complexes |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422015000500715&lng=en&tlng=en |
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