Identifying Cattle Breed-Specific Partner Choice of Transcription Factors during the African Trypanosomiasis Disease Progression Using Bioinformatics Analysis
African Animal Trypanosomiasis (AAT) is a disease caused by pathogenic trypanosomes which affects millions of livestock every year causing huge economic losses in agricultural production especially in sub-Saharan Africa. The disease is spread by the tsetse fly which carries the parasite in its saliv...
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| Format: | Article |
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MDPI AG
2020-05-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/8/2/246 |
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| author | Abirami Rajavel Felix Heinrich Armin Otto Schmitt Mehmet Gültas |
| author_facet | Abirami Rajavel Felix Heinrich Armin Otto Schmitt Mehmet Gültas |
| author_sort | Abirami Rajavel |
| collection | DOAJ |
| description | African Animal Trypanosomiasis (AAT) is a disease caused by pathogenic trypanosomes which affects millions of livestock every year causing huge economic losses in agricultural production especially in sub-Saharan Africa. The disease is spread by the tsetse fly which carries the parasite in its saliva. During the disease progression, the cattle are prominently subjected to anaemia, weight loss, intermittent fever, chills, neuronal degeneration, congestive heart failure, and finally death. According to their different genetic programs governing the level of tolerance to AAT, cattle breeds are classified as either resistant or susceptible. In this study, we focus on the cattle breeds N’Dama and Boran which are known to be resistant and susceptible to trypanosomiasis, respectively. Despite the rich literature on both breeds, the gene regulatory mechanisms of the underlying biological processes for their resistance and susceptibility have not been extensively studied. To address the limited knowledge about the tissue-specific transcription factor (TF) cooperations associated with trypanosomiasis, we investigated gene expression data from these cattle breeds computationally. Consequently, we identified significant cooperative TF pairs (especially <inline-formula> <math display="inline"> <semantics> <mrow> <mi>D</mi> <mi>B</mi> <mi>P</mi> <mo>−</mo> <mi>P</mi> <mi>P</mi> <mi>A</mi> <mi>R</mi> <mi>A</mi> </mrow> </semantics> </math> </inline-formula> and <inline-formula> <math display="inline"> <semantics> <mrow> <mi>D</mi> <mi>B</mi> <mi>P</mi> <mo>−</mo> <mi>T</mi> <mi>H</mi> <mi>A</mi> <mi>P</mi> <mn>1</mn> </mrow> </semantics> </math> </inline-formula> in N’Dama and <inline-formula> <math display="inline"> <semantics> <mrow> <mi>D</mi> <mi>B</mi> <mi>P</mi> <mo>−</mo> <mi>P</mi> <mi>A</mi> <mi>X</mi> <mn>8</mn> </mrow> </semantics> </math> </inline-formula> in Boran liver tissue) which could help understand the underlying AAT tolerance/susceptibility mechanism in both cattle breeds. |
| first_indexed | 2024-03-10T19:39:00Z |
| format | Article |
| id | doaj.art-c93dbbd04d374495b39ea00fc5051a6c |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T19:39:00Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-c93dbbd04d374495b39ea00fc5051a6c2023-11-20T01:28:44ZengMDPI AGVaccines2076-393X2020-05-018224610.3390/vaccines8020246Identifying Cattle Breed-Specific Partner Choice of Transcription Factors during the African Trypanosomiasis Disease Progression Using Bioinformatics AnalysisAbirami Rajavel0Felix Heinrich1Armin Otto Schmitt2Mehmet Gültas3Breeding Informatics Group, Department of Animal Sciences, Georg-August University, Margarethe von Wrangell-Weg 7, 37075 Göttingen, GermanyBreeding Informatics Group, Department of Animal Sciences, Georg-August University, Margarethe von Wrangell-Weg 7, 37075 Göttingen, GermanyBreeding Informatics Group, Department of Animal Sciences, Georg-August University, Margarethe von Wrangell-Weg 7, 37075 Göttingen, GermanyBreeding Informatics Group, Department of Animal Sciences, Georg-August University, Margarethe von Wrangell-Weg 7, 37075 Göttingen, GermanyAfrican Animal Trypanosomiasis (AAT) is a disease caused by pathogenic trypanosomes which affects millions of livestock every year causing huge economic losses in agricultural production especially in sub-Saharan Africa. The disease is spread by the tsetse fly which carries the parasite in its saliva. During the disease progression, the cattle are prominently subjected to anaemia, weight loss, intermittent fever, chills, neuronal degeneration, congestive heart failure, and finally death. According to their different genetic programs governing the level of tolerance to AAT, cattle breeds are classified as either resistant or susceptible. In this study, we focus on the cattle breeds N’Dama and Boran which are known to be resistant and susceptible to trypanosomiasis, respectively. Despite the rich literature on both breeds, the gene regulatory mechanisms of the underlying biological processes for their resistance and susceptibility have not been extensively studied. To address the limited knowledge about the tissue-specific transcription factor (TF) cooperations associated with trypanosomiasis, we investigated gene expression data from these cattle breeds computationally. Consequently, we identified significant cooperative TF pairs (especially <inline-formula> <math display="inline"> <semantics> <mrow> <mi>D</mi> <mi>B</mi> <mi>P</mi> <mo>−</mo> <mi>P</mi> <mi>P</mi> <mi>A</mi> <mi>R</mi> <mi>A</mi> </mrow> </semantics> </math> </inline-formula> and <inline-formula> <math display="inline"> <semantics> <mrow> <mi>D</mi> <mi>B</mi> <mi>P</mi> <mo>−</mo> <mi>T</mi> <mi>H</mi> <mi>A</mi> <mi>P</mi> <mn>1</mn> </mrow> </semantics> </math> </inline-formula> in N’Dama and <inline-formula> <math display="inline"> <semantics> <mrow> <mi>D</mi> <mi>B</mi> <mi>P</mi> <mo>−</mo> <mi>P</mi> <mi>A</mi> <mi>X</mi> <mn>8</mn> </mrow> </semantics> </math> </inline-formula> in Boran liver tissue) which could help understand the underlying AAT tolerance/susceptibility mechanism in both cattle breeds.https://www.mdpi.com/2076-393X/8/2/246Animal African TrypanosomiasisBoranN’DamatrypanotolerancesusceptibilityPC-TraFF |
| spellingShingle | Abirami Rajavel Felix Heinrich Armin Otto Schmitt Mehmet Gültas Identifying Cattle Breed-Specific Partner Choice of Transcription Factors during the African Trypanosomiasis Disease Progression Using Bioinformatics Analysis Vaccines Animal African Trypanosomiasis Boran N’Dama trypanotolerance susceptibility PC-TraFF |
| title | Identifying Cattle Breed-Specific Partner Choice of Transcription Factors during the African Trypanosomiasis Disease Progression Using Bioinformatics Analysis |
| title_full | Identifying Cattle Breed-Specific Partner Choice of Transcription Factors during the African Trypanosomiasis Disease Progression Using Bioinformatics Analysis |
| title_fullStr | Identifying Cattle Breed-Specific Partner Choice of Transcription Factors during the African Trypanosomiasis Disease Progression Using Bioinformatics Analysis |
| title_full_unstemmed | Identifying Cattle Breed-Specific Partner Choice of Transcription Factors during the African Trypanosomiasis Disease Progression Using Bioinformatics Analysis |
| title_short | Identifying Cattle Breed-Specific Partner Choice of Transcription Factors during the African Trypanosomiasis Disease Progression Using Bioinformatics Analysis |
| title_sort | identifying cattle breed specific partner choice of transcription factors during the african trypanosomiasis disease progression using bioinformatics analysis |
| topic | Animal African Trypanosomiasis Boran N’Dama trypanotolerance susceptibility PC-TraFF |
| url | https://www.mdpi.com/2076-393X/8/2/246 |
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