Hypothalamic Proopiomelanocortin Is Necessary for Normal Glucose Homeostasis in Female Mice

Hypothalamic Proopiomelanocortin Is Necessary for Normal Glucose Homeostasis in Female Mice

The arcuate nucleus of the hypothalamus is a key regulator of energy balance and glucose homeostasis. In particular, arcuate proopiomelanocortin (POMC) neurons inhibit food intake, stimulate energy expenditure and increase glucose tolerance. The interruption of insulin or glucose signaling in POMC n...

Full description

Bibliographic Details
Main Authors:	Ramiro Alsina, Milagros Trotta, Viviana Florencia Bumaschny
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-09-01
Series:	Frontiers in Endocrinology
Subjects:	proopiomelanocortin glucose tolerance insulin sensitivity diabetes hypothalamus Esr1
Online Access:	https://www.frontiersin.org/article/10.3389/fendo.2018.00554/full

Similar Items

Hypothalamic Pomc expression restricted to GABAergic neurons suppresses Npy overexpression and restores food intake in obese mice
by: Milagros Trotta, et al.
Published: (2020-07-01)

Unraveling the central proopiomelanocortin neural circuits
by: Aaron J. Mercer, et al.
Published: (2013-02-01)

Central Dicer-miR-103/107 controls developmental switch of POMC progenitors into NPY neurons and impacts glucose homeostasis
by: Sophie Croizier, et al.
Published: (2018-10-01)

Endocannabinoid Signaling at Hypothalamic Steroidogenic Factor-1/Proopiomelanocortin Synapses Is Sex- and Diet-Sensitive
by: Carolina Fabelo, et al.
Published: (2018-06-01)

The homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice
by: Hui Yu, et al.
Published: (2024-09-01)

Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress
by: Yoko Yagishita, et al.
Published: (2017-02-01)

One-month of high-intensity exercise did not change the food intake and the hypothalamic arcuate nucleus proopiomelanocortin and neuropeptide Y expression levels in male Wistar rats
by: Khajehnasiri Nazli, et al.
Published: (2019-01-01)

Analysis of the Glucose-Dependent Transcriptome in Murine Hypothalamic Cells
by: Leonhard Webert, et al.
Published: (2022-02-01)

Study of glucose homeostasis in burnout cases using an oral glucose tolerance test
by: Anna-Karin Lennartsson, et al.
Published: (2025-12-01)

Anti-Obesity Effect of Pine Needle Extract on High-Fat Diet-Induced Obese Mice
by: Eun A. Kim, et al.
Published: (2021-04-01)

Hypothalamic CREB Regulates the Expression of Pomc-Processing Enzyme Pcsk2
by: Ariane Maria Zanesco, et al.
Published: (2022-06-01)

Targeting the immunoproteasome in hypothalamic neurons as a novel therapeutic strategy for high-fat diet-induced obesity and metabolic dysregulation
by: Nicolás Albornoz, et al.
Published: (2024-08-01)

Pathophysiology and clinical characteristics of hypothalamic obesity in children and adolescents
by: Ja Hye Kim, et al.
Published: (2013-12-01)

Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity
by: Katharina Timper, et al.
Published: (2017-06-01)

Sweet taste signaling functions as a hypothalamic glucose sensor
by: Xueying Ren, et al.
Published: (2009-06-01)

Cholecystokinin-expressing neurons of the ventromedial hypothalamic nucleus control energy homeostasis
by: Vasileios Eftychidis, et al.
Published: (2024-10-01)

Hypothalamic Mitochondrial Dysfunction as a Target in Obesity and Metabolic Disease
by: Juan Cunarro, et al.
Published: (2018-05-01)

Interactive effects of neonatal exposure to monosodium glutamate and aspartame on glucose homeostasis
by: Collison Kate S, et al.
Published: (2012-06-01)

Friedreich's Ataxia and Glucose Metabolism
by: J Gordon Millichap
Published: (1988-08-01)

Overexpression of the Gene Encoding Neurosecretory Protein GL Precursor Prevents Excessive Fat Accumulation in the Adipose Tissue of Mice Fed a Long-Term High-Fat Diet
by: Keisuke Fukumura, et al.
Published: (2021-10-01)

Glucose-sensitive hypothalamic nuclei traced through functional magnetic resonance imaging
by: Jorge Manuel, et al.
Published: (2023-12-01)

Sex-specific hypothalamic neuropathology and glucose metabolism in an amyloidosis transgenic mouse model of Alzheimer’s disease
by: Guibo Qi, et al.
Published: (2024-09-01)

Maternal glucose intolerance during pregnancy affects offspring POMC expression and results in adult metabolic alterations in a sex-dependent manner
by: Marina Galleazzo Martins, et al.
Published: (2023-06-01)

Systemic Glucose Administration Alters Water Diffusion and Microvascular Blood Flow in Mouse Hypothalamic Nuclei – An fMRI Study
by: Blanca Lizarbe, et al.
Published: (2019-09-01)

Metabolites Link Intake of a Healthy Diet to Better Insulin and Glucose Homeostasis in the Microbiome and Insulin Longitudinal Evaluation Study (MILES)
by: Alexis C Wood, et al.
Published: (2024-11-01)

GLUCOSE HOMEOSTASIS AND ΑSSESSMENT OF Β-CELL FUNCTION BY 3-HOUR ORAL GLUCOSE TOLERANCE (OGTT) IN PATIENTS WITH Β-THALASSEMIA MAJOR WITH SERUM FERRITIN BELOW 1,000 NG/DL: RESULTS FROM A SINGLE ICET-A CENTRE
by: Vincenzo De Sanctis, et al.
Published: (2023-01-01)

Acetate attenuates hypothalamic pyroptosis in experimentally induced polycystic ovarian syndrome
by: Kehinde S. Olaniyi, et al.
Published: (2024-09-01)

Cannabidiol treatment improves metabolic profile and decreases hypothalamic inflammation caused by maternal obesity
by: Fernanda da Silva Rodrigues, et al.
Published: (2023-03-01)

The contribution of hypothalamic macroglia to the regulation of energy homeostasis
by: Laura B Buckman, et al.
Published: (2014-10-01)

Effects of Dietary Calcium Propionate Supplementation on Hypothalamic Neuropeptide Messenger RNA Expression and Growth Performance in Finishing Rambouillet Lambs
by: Oswaldo Cifuentes-Lopez, et al.
Published: (2021-06-01)

The Involvement of Endogenous Enkephalins in Glucose Homeostasis
by: Vanessa Escolero, et al.
Published: (2023-02-01)

Age-Dependent Changes in the mRNA Levels of Neuropeptide Y, Proopiomelanocortin, and Corticotropin-Releasing Factor in the Hypothalamus in Growing Broiler Chicks
by: Takaoki Saneyasu, et al.
Published: (2013-10-01)

Insulin at the intersection of thermoregulation and glucose homeostasis
by: Nathan C. Winn, et al.
Published: (2024-03-01)

Treatment of Acquired Hypothalamic Obesity: Now and the Future
by: Paul Dimitri, et al.
Published: (2022-04-01)

Insulin regulates POMC neuronal plasticity to control glucose metabolism
by: Garron T Dodd, et al.
Published: (2018-09-01)

Glycolysis in the control of blood glucose homeostasis
by: Xin Guo, et al.
Published: (2012-08-01)

Recurrent reactive hypoglycemia due to clozapine‐induced glucose intolerance: A case report
by: Fumihiko Kawai, et al.
Published: (2023-12-01)

Susceptibility to Hyperglycemia in Rats With Stress-Induced Depressive-Like Behavior: Involvement of IL-6 Mediated Glucose Homeostasis Signaling
by: Xiaojuan Li, et al.
Published: (2020-06-01)

Estrogen and Glycemic Homeostasis: The Fundamental Role of Nuclear Estrogen Receptors ESR1/ESR2 in Glucose Transporter GLUT4 Regulation
by: Karen Cristina Rego Gregorio, et al.
Published: (2021-01-01)

The ventromedial hypothalamic nucleus: watchdog of whole-body glucose homeostasis
by: Longlong Tu, et al.
Published: (2022-05-01)