METTL14-mediated N6-methyladenosine modification of ITGB4 mRNA inhibits metastasis of clear cell renal cell carcinoma

METTL14-mediated N6-methyladenosine modification of ITGB4 mRNA inhibits metastasis of clear cell renal cell carcinoma

Abstract Background Integrin β4 (ITGB4) participates in tumorigenesis and progression of several malignancies, but its role and related mechanisms in clear cell renal cell carcinoma (ccRCC) remain unclear. Methods Quantitative real-time PCR (qRT-PCR), western blot and immunohistochemistry were used...

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Bibliographic Details
Main Authors: Zhuonan Liu, Tianshui Sun, Chiyuan Piao, Zhe Zhang, Chuize Kong
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Cell Communication and Signaling
Subjects:
ccRCC
Migration
Invasion
Metastasis
EMT
ITGB4
Online Access:https://doi.org/10.1186/s12964-022-00831-5

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