The effect of synbiotics supplementation on anthropometric indicators and lipid profiles in women with polycystic ovary syndrome: a randomized controlled trial
Abstract Background Different therapies have been suggested for polycystic ovary syndrome (PCOS), but changes in lifestyle and diet have been considered. Diet and dietary factors can be very effective in modifying the disease. The positive effects of probiotic and synbiotics supplementation on impro...
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| Format: | Article |
| Language: | English |
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BMC
2020-04-01
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| Series: | Lipids in Health and Disease |
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| Online Access: | http://link.springer.com/article/10.1186/s12944-020-01244-4 |
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| author | Elham Karimi Javad Heshmati Nooshin Shirzad Samira Vesali Mohammad Javad Hosseinzadeh-Attar Ashraf Moini Mahdi Sepidarkish |
| author_facet | Elham Karimi Javad Heshmati Nooshin Shirzad Samira Vesali Mohammad Javad Hosseinzadeh-Attar Ashraf Moini Mahdi Sepidarkish |
| author_sort | Elham Karimi |
| collection | DOAJ |
| description | Abstract Background Different therapies have been suggested for polycystic ovary syndrome (PCOS), but changes in lifestyle and diet have been considered. Diet and dietary factors can be very effective in modifying the disease. The positive effects of probiotic and synbiotics supplementation on improving lipid profiles and anthropometric indices have been examined in various diseases. This study was conducted to evaluate the effects of synbiotics supplementation on lipid and anthropometric profiles in infertile women with PCOS. Methods PCOS patients aged 19–37 years old were randomized to receive either synbiotics supplement (n = 50) or placebo (n = 49) for 12 weeks. Results Consumption of synbiotics compared to the placebo, resulted in a significant decrease in Low-density lipoprotein cholesterol (LDL) value (Change Mean Difference (CMD): 4.66, 95%CI: 0.20, 9.13) and a significant increase in high-density lipoprotein cholesterol (HDL) (CMD: 1.80, 95%CI: 0.34, 3.26). Although we failed to find a significant effect of synbiotics consumption on total cholesterol (TC) and triglyceride (TG) levels. We did not find differences in anthropometric indices between groups. Conclusions Overall, 12 weeks of synbiotics supplementation among PCOS women resulted in beneficial effects on LDL and HDL, although it is not yet clear how much our findings are clinically significant and more clinical studies with larger sample sizes are still needed. Trial registration Iranian Registry of clinical Trial, IRCT.ir, ID: IRCT2014110515536N2 . Registered on 19 December 2015. Graphical abstract |
| first_indexed | 2024-12-23T05:39:48Z |
| format | Article |
| id | doaj.art-c9449a42366642cb961631373e527a9f |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-23T05:39:48Z |
| publishDate | 2020-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-c9449a42366642cb961631373e527a9f2022-12-21T17:58:14ZengBMCLipids in Health and Disease1476-511X2020-04-011911910.1186/s12944-020-01244-4The effect of synbiotics supplementation on anthropometric indicators and lipid profiles in women with polycystic ovary syndrome: a randomized controlled trialElham Karimi0Javad Heshmati1Nooshin Shirzad2Samira Vesali3Mohammad Javad Hosseinzadeh-Attar4Ashraf Moini5Mahdi Sepidarkish6Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical SciencesDepartment of Nutritional Science, School of Nutritional Science and Food Technology, Kermanshah University of Medical SciencesEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesReproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECRDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, International Campus, Tehran University of Medical Sciences (IC-TUMS)Department of Gynecology and Obstetrics, Roointan-Arash Maternity Hospital, Tehran University of Medical SciencesDepartment of Biostatistics and Epidemiology, School of Public Health, Babol University of Medical SciencesAbstract Background Different therapies have been suggested for polycystic ovary syndrome (PCOS), but changes in lifestyle and diet have been considered. Diet and dietary factors can be very effective in modifying the disease. The positive effects of probiotic and synbiotics supplementation on improving lipid profiles and anthropometric indices have been examined in various diseases. This study was conducted to evaluate the effects of synbiotics supplementation on lipid and anthropometric profiles in infertile women with PCOS. Methods PCOS patients aged 19–37 years old were randomized to receive either synbiotics supplement (n = 50) or placebo (n = 49) for 12 weeks. Results Consumption of synbiotics compared to the placebo, resulted in a significant decrease in Low-density lipoprotein cholesterol (LDL) value (Change Mean Difference (CMD): 4.66, 95%CI: 0.20, 9.13) and a significant increase in high-density lipoprotein cholesterol (HDL) (CMD: 1.80, 95%CI: 0.34, 3.26). Although we failed to find a significant effect of synbiotics consumption on total cholesterol (TC) and triglyceride (TG) levels. We did not find differences in anthropometric indices between groups. Conclusions Overall, 12 weeks of synbiotics supplementation among PCOS women resulted in beneficial effects on LDL and HDL, although it is not yet clear how much our findings are clinically significant and more clinical studies with larger sample sizes are still needed. Trial registration Iranian Registry of clinical Trial, IRCT.ir, ID: IRCT2014110515536N2 . Registered on 19 December 2015. Graphical abstracthttp://link.springer.com/article/10.1186/s12944-020-01244-4Polycystic ovary syndromeSynbioticsCholesterol, LDLCholesterol, HDLTriglycerides |
| spellingShingle | Elham Karimi Javad Heshmati Nooshin Shirzad Samira Vesali Mohammad Javad Hosseinzadeh-Attar Ashraf Moini Mahdi Sepidarkish The effect of synbiotics supplementation on anthropometric indicators and lipid profiles in women with polycystic ovary syndrome: a randomized controlled trial Lipids in Health and Disease Polycystic ovary syndrome Synbiotics Cholesterol, LDL Cholesterol, HDL Triglycerides |
| title | The effect of synbiotics supplementation on anthropometric indicators and lipid profiles in women with polycystic ovary syndrome: a randomized controlled trial |
| title_full | The effect of synbiotics supplementation on anthropometric indicators and lipid profiles in women with polycystic ovary syndrome: a randomized controlled trial |
| title_fullStr | The effect of synbiotics supplementation on anthropometric indicators and lipid profiles in women with polycystic ovary syndrome: a randomized controlled trial |
| title_full_unstemmed | The effect of synbiotics supplementation on anthropometric indicators and lipid profiles in women with polycystic ovary syndrome: a randomized controlled trial |
| title_short | The effect of synbiotics supplementation on anthropometric indicators and lipid profiles in women with polycystic ovary syndrome: a randomized controlled trial |
| title_sort | effect of synbiotics supplementation on anthropometric indicators and lipid profiles in women with polycystic ovary syndrome a randomized controlled trial |
| topic | Polycystic ovary syndrome Synbiotics Cholesterol, LDL Cholesterol, HDL Triglycerides |
| url | http://link.springer.com/article/10.1186/s12944-020-01244-4 |
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