The endoplasmic reticulum stress response in aging and age-related diseases

The endoplasmic reticulum stress response in aging and age-related diseases

The endoplasmic reticulum(ER) is a multifunctional organelle within which protein folding, lipid biosynthesis, and calcium storage occurs. Perturbations such as energy or nutrient depletion, disturbances in calcium or redox status that disrupt ER homeostasis lead to the misfolding of proteins, ER s...

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Bibliographic Details
Main Authors:	Nirinjini eNaidoo, Marishka eBrown
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2012-07-01
Series:	Frontiers in Physiology
Subjects:	Endoplasmic Reticulum Unfolded Protein Response aging neuroscience age-related disease BiP/GRP78
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00263/full

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