Monocyte-Derived Dendritic Cells Dictate the Memory Differentiation of CD8+ T Cells During Acute Infection
Monocyte-derived dendritic cells (moDCs) have been shown to robustly expand during infection; however, their roles in anti-infectious immunity remain unclear. Here, we found that moDCs were dramatically increased in the secondary lymphoid organs during acute LCMV infection in an interferon-γ (IFN-γ)...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-08-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.01887/full |
| _version_ | 1828409497467486208 |
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| author | Kwang-Soo Shin Insu Jeon Byung-Seok Kim Il-Kyu Kim Young-Jun Park Choong-Hyun Koh Boyeong Song Jeong-Mi Lee Jiyoung Lim Eun-Ah Bae Hyungseok Seo Young Ho Ban Sang-Jun Ha Chang-Yuil Kang Chang-Yuil Kang |
| author_facet | Kwang-Soo Shin Insu Jeon Byung-Seok Kim Il-Kyu Kim Young-Jun Park Choong-Hyun Koh Boyeong Song Jeong-Mi Lee Jiyoung Lim Eun-Ah Bae Hyungseok Seo Young Ho Ban Sang-Jun Ha Chang-Yuil Kang Chang-Yuil Kang |
| author_sort | Kwang-Soo Shin |
| collection | DOAJ |
| description | Monocyte-derived dendritic cells (moDCs) have been shown to robustly expand during infection; however, their roles in anti-infectious immunity remain unclear. Here, we found that moDCs were dramatically increased in the secondary lymphoid organs during acute LCMV infection in an interferon-γ (IFN-γ)-dependent manner. We also found that priming by moDCs enhanced the differentiation of memory CD8+ T cells compared to differentiation primed by conventional dendritic cells (cDCs) through upregulation of Eomesodermin (Eomes) and T cell factor-1 (TCF-1) expression in CD8+ T cells. Consequently, impaired memory formation of CD8+ T cells in mice that had reduced numbers of moDCs led to defective clearance of pathogens upon rechallenge. Mechanistically, attenuated interleukin-2 (IL-2) signaling in CD8+ T cells primed by moDCs was responsible for the enhanced memory programming of CD8+ T cells. Therefore, our findings unveil a specialization of the antigen-presenting cell subsets in the fate determination of CD8+ T cells during infection and pave the way for the development of a novel therapeutic intervention on infection. |
| first_indexed | 2024-12-10T11:56:36Z |
| format | Article |
| id | doaj.art-c9487de59adf431798a7495f20d89d46 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T11:56:36Z |
| publishDate | 2019-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-c9487de59adf431798a7495f20d89d462022-12-22T01:49:46ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-08-011010.3389/fimmu.2019.01887469369Monocyte-Derived Dendritic Cells Dictate the Memory Differentiation of CD8+ T Cells During Acute InfectionKwang-Soo Shin0Insu Jeon1Byung-Seok Kim2Il-Kyu Kim3Young-Jun Park4Choong-Hyun Koh5Boyeong Song6Jeong-Mi Lee7Jiyoung Lim8Eun-Ah Bae9Hyungseok Seo10Young Ho Ban11Sang-Jun Ha12Chang-Yuil Kang13Chang-Yuil Kang14Laboratory of Immunology, College of Pharmacy, Seoul National University, Seoul, South KoreaLaboratory of Immunology, Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South KoreaLaboratory of Immune Regulation, College of Pharmacy, Seoul National University, Seoul, South KoreaLaboratory of Immunology, College of Pharmacy, Seoul National University, Seoul, South KoreaLaboratory of Immune Regulation, College of Pharmacy, Seoul National University, Seoul, South KoreaLaboratory of Immunology, College of Pharmacy, Seoul National University, Seoul, South KoreaLaboratory of Immunology, Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South KoreaLaboratory of Immunology, College of Pharmacy, Seoul National University, Seoul, South KoreaLaboratory of Immunology, Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South KoreaLaboratory of Immunology, Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South KoreaLaboratory of Immunology, Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South KoreaDepartment of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South KoreaDepartment of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South KoreaLaboratory of Immunology, College of Pharmacy, Seoul National University, Seoul, South KoreaLaboratory of Immunology, Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South KoreaMonocyte-derived dendritic cells (moDCs) have been shown to robustly expand during infection; however, their roles in anti-infectious immunity remain unclear. Here, we found that moDCs were dramatically increased in the secondary lymphoid organs during acute LCMV infection in an interferon-γ (IFN-γ)-dependent manner. We also found that priming by moDCs enhanced the differentiation of memory CD8+ T cells compared to differentiation primed by conventional dendritic cells (cDCs) through upregulation of Eomesodermin (Eomes) and T cell factor-1 (TCF-1) expression in CD8+ T cells. Consequently, impaired memory formation of CD8+ T cells in mice that had reduced numbers of moDCs led to defective clearance of pathogens upon rechallenge. Mechanistically, attenuated interleukin-2 (IL-2) signaling in CD8+ T cells primed by moDCs was responsible for the enhanced memory programming of CD8+ T cells. Therefore, our findings unveil a specialization of the antigen-presenting cell subsets in the fate determination of CD8+ T cells during infection and pave the way for the development of a novel therapeutic intervention on infection.https://www.frontiersin.org/article/10.3389/fimmu.2019.01887/fullmonocyte-derived dendritic cellsmemory CD8+ T cellsIFN-γLCMVacute infection |
| spellingShingle | Kwang-Soo Shin Insu Jeon Byung-Seok Kim Il-Kyu Kim Young-Jun Park Choong-Hyun Koh Boyeong Song Jeong-Mi Lee Jiyoung Lim Eun-Ah Bae Hyungseok Seo Young Ho Ban Sang-Jun Ha Chang-Yuil Kang Chang-Yuil Kang Monocyte-Derived Dendritic Cells Dictate the Memory Differentiation of CD8+ T Cells During Acute Infection Frontiers in Immunology monocyte-derived dendritic cells memory CD8+ T cells IFN-γ LCMV acute infection |
| title | Monocyte-Derived Dendritic Cells Dictate the Memory Differentiation of CD8+ T Cells During Acute Infection |
| title_full | Monocyte-Derived Dendritic Cells Dictate the Memory Differentiation of CD8+ T Cells During Acute Infection |
| title_fullStr | Monocyte-Derived Dendritic Cells Dictate the Memory Differentiation of CD8+ T Cells During Acute Infection |
| title_full_unstemmed | Monocyte-Derived Dendritic Cells Dictate the Memory Differentiation of CD8+ T Cells During Acute Infection |
| title_short | Monocyte-Derived Dendritic Cells Dictate the Memory Differentiation of CD8+ T Cells During Acute Infection |
| title_sort | monocyte derived dendritic cells dictate the memory differentiation of cd8 t cells during acute infection |
| topic | monocyte-derived dendritic cells memory CD8+ T cells IFN-γ LCMV acute infection |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.01887/full |
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