Efficacy of Multifocal Soft Contact Lenses in Reducing Myopia Progression Among Taiwanese Schoolchildren: A Randomized Paired-Eye Clinical Trial
Abstract Introduction To evaluate the efficacy and safety of myopia control using a multifocal soft contact lens designed with high peripheral add power in schoolchildren. Methods This 1-year multi-center, prospective, randomized, double-blind, controlled study enrolled myopic schoolchildren aged 6–...
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2023-12-01
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| Series: | Ophthalmology and Therapy |
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| Online Access: | https://doi.org/10.1007/s40123-023-00859-x |
| _version_ | 1797355948474368000 |
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| author | Yao-Lin Liu Ken-Kuo Lin Li-Sheng Cheng Chao-Wen Lin Jiahn-Shing Lee Chiun-Ho Hou Tzu-Hsun Tsai |
| author_facet | Yao-Lin Liu Ken-Kuo Lin Li-Sheng Cheng Chao-Wen Lin Jiahn-Shing Lee Chiun-Ho Hou Tzu-Hsun Tsai |
| author_sort | Yao-Lin Liu |
| collection | DOAJ |
| description | Abstract Introduction To evaluate the efficacy and safety of myopia control using a multifocal soft contact lens designed with high peripheral add power in schoolchildren. Methods This 1-year multi-center, prospective, randomized, double-blind, controlled study enrolled myopic schoolchildren aged 6–15 years with refractive errors between − 1.0 D and − 10.0 D. Each participant was randomly allocated to wear a daily disposable multifocal soft contact lens as the treatment in one eye and a single-vision soft contact lens as the control in the other eye. The primary endpoints were changes in the cycloplegic spherical equivalent (SE) and axial length at 1 year. Results Fifty-two of the 59 participants (88.1%) completed the study protocol. The mean change in SE was − 0.73 ± 0.40 D in the treatment group. and − 0.85 ± 0.51 D in the control group (mean difference: − 0.12 ± 0.34 D, p = 0.012). The mean change in axial length was 0.25 ± 0.14 mm in the treatment group, and 0.33 ± 0.17 mm in the control group (mean difference: 0.08 ± 0.10 mm, p < 0.001). The treatment was well tolerated, and no serious adverse events were observed. Conclusions Treatment with multifocal soft contact lenses with high peripheral add power was effective in controlling the progression of myopia and axial length elongation in myopic schoolchildren. |
| first_indexed | 2024-03-08T14:18:31Z |
| format | Article |
| id | doaj.art-c94b893a86934d388f6447c53011b91e |
| institution | Directory Open Access Journal |
| issn | 2193-8245 2193-6528 |
| language | English |
| last_indexed | 2024-03-08T14:18:31Z |
| publishDate | 2023-12-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Ophthalmology and Therapy |
| spelling | doaj.art-c94b893a86934d388f6447c53011b91e2024-01-14T12:14:36ZengAdis, Springer HealthcareOphthalmology and Therapy2193-82452193-65282023-12-0113254155210.1007/s40123-023-00859-xEfficacy of Multifocal Soft Contact Lenses in Reducing Myopia Progression Among Taiwanese Schoolchildren: A Randomized Paired-Eye Clinical TrialYao-Lin Liu0Ken-Kuo Lin1Li-Sheng Cheng2Chao-Wen Lin3Jiahn-Shing Lee4Chiun-Ho Hou5Tzu-Hsun Tsai6Department of Ophthalmology, College of Medicine, National Taiwan University Hospital, National Taiwan UniversityDepartment of Ophthalmology, Chang Gung Memorial Hospital Linkou BranchesGreat Vision Eye ClinicDepartment of Ophthalmology, College of Medicine, National Taiwan University Hospital, National Taiwan UniversityDepartment of Ophthalmology, Chang Gung Memorial Hospital Taipei BranchesDepartment of Ophthalmology, College of Medicine, National Taiwan University Hospital, National Taiwan UniversityDepartment of Ophthalmology, College of Medicine, National Taiwan University Hospital, National Taiwan UniversityAbstract Introduction To evaluate the efficacy and safety of myopia control using a multifocal soft contact lens designed with high peripheral add power in schoolchildren. Methods This 1-year multi-center, prospective, randomized, double-blind, controlled study enrolled myopic schoolchildren aged 6–15 years with refractive errors between − 1.0 D and − 10.0 D. Each participant was randomly allocated to wear a daily disposable multifocal soft contact lens as the treatment in one eye and a single-vision soft contact lens as the control in the other eye. The primary endpoints were changes in the cycloplegic spherical equivalent (SE) and axial length at 1 year. Results Fifty-two of the 59 participants (88.1%) completed the study protocol. The mean change in SE was − 0.73 ± 0.40 D in the treatment group. and − 0.85 ± 0.51 D in the control group (mean difference: − 0.12 ± 0.34 D, p = 0.012). The mean change in axial length was 0.25 ± 0.14 mm in the treatment group, and 0.33 ± 0.17 mm in the control group (mean difference: 0.08 ± 0.10 mm, p < 0.001). The treatment was well tolerated, and no serious adverse events were observed. Conclusions Treatment with multifocal soft contact lenses with high peripheral add power was effective in controlling the progression of myopia and axial length elongation in myopic schoolchildren.https://doi.org/10.1007/s40123-023-00859-xAxial lengthChildrenMyopia controlMultifocal soft contact lensPeripheral myopic defocus |
| spellingShingle | Yao-Lin Liu Ken-Kuo Lin Li-Sheng Cheng Chao-Wen Lin Jiahn-Shing Lee Chiun-Ho Hou Tzu-Hsun Tsai Efficacy of Multifocal Soft Contact Lenses in Reducing Myopia Progression Among Taiwanese Schoolchildren: A Randomized Paired-Eye Clinical Trial Ophthalmology and Therapy Axial length Children Myopia control Multifocal soft contact lens Peripheral myopic defocus |
| title | Efficacy of Multifocal Soft Contact Lenses in Reducing Myopia Progression Among Taiwanese Schoolchildren: A Randomized Paired-Eye Clinical Trial |
| title_full | Efficacy of Multifocal Soft Contact Lenses in Reducing Myopia Progression Among Taiwanese Schoolchildren: A Randomized Paired-Eye Clinical Trial |
| title_fullStr | Efficacy of Multifocal Soft Contact Lenses in Reducing Myopia Progression Among Taiwanese Schoolchildren: A Randomized Paired-Eye Clinical Trial |
| title_full_unstemmed | Efficacy of Multifocal Soft Contact Lenses in Reducing Myopia Progression Among Taiwanese Schoolchildren: A Randomized Paired-Eye Clinical Trial |
| title_short | Efficacy of Multifocal Soft Contact Lenses in Reducing Myopia Progression Among Taiwanese Schoolchildren: A Randomized Paired-Eye Clinical Trial |
| title_sort | efficacy of multifocal soft contact lenses in reducing myopia progression among taiwanese schoolchildren a randomized paired eye clinical trial |
| topic | Axial length Children Myopia control Multifocal soft contact lens Peripheral myopic defocus |
| url | https://doi.org/10.1007/s40123-023-00859-x |
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