Multifocal Primary Neoplasms in Kidney Allografts: Evaluation of Two Cases
<p>Renal cell carcinoma (RCC) is the fifth most common malignancy in kidney transplant recipients, with increased risk arising due to immunosuppression. De novo RCC occurrence in kidney allografts is much less common when compared with the native kidneys. Multifocal RCC in allograft kidneys is...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Codon Publications
2016-06-01
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| Series: | Journal of Kidney Cancer and VHL |
| Subjects: | |
| Online Access: | http://jkcvhl.com/index.php/jkcvhl/article/view/53 |
| _version_ | 1830381535464783872 |
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| author | Robert J Ellis Keng Lim Ng Hemamali Samaratunga Sharon J Del Vecchio Simon T Wood Glenda C Gobe |
| author_facet | Robert J Ellis Keng Lim Ng Hemamali Samaratunga Sharon J Del Vecchio Simon T Wood Glenda C Gobe |
| author_sort | Robert J Ellis |
| collection | DOAJ |
| description | <p>Renal cell carcinoma (RCC) is the fifth most common malignancy in kidney transplant recipients, with increased risk arising due to immunosuppression. De novo RCC occurrence in kidney allografts is much less common when compared with the native kidneys. Multifocal RCC in allograft kidneys is rarely described. In this report, we discuss two cases of de novo multifocal renal neoplasms in allograft kidneys. Case 1 had three distinct neoplastic lesions of >5 mm, and case 2 had four. Using the World Health Organization 2016 classification of adult renal tumours, case 1 had one clear-cell (cc) RCC (grade 3) and two papillary adenomas; all confined to the kidney. Case 2 had a nodular lesion classified as ccRCC (grade 4) with focal rhabdoid differentiation and some infiltration of renal sinus fat; a cc tubulopapillary RCC; a multilocular cystic renal neoplasm of low malignant potential; and a mucinous tubular and spindle cell carcinoma; the last three all confined to the kidney. This is the first report of mucinous tubular and spindle cell carcinoma in a kidney allograft. When considering multifocal RCC with discordant histology, it is likely that these represent independent tumourigenic events.</p> |
| first_indexed | 2024-12-20T09:51:25Z |
| format | Article |
| id | doaj.art-c94e142e952d44018003a3885b81590e |
| institution | Directory Open Access Journal |
| issn | 2203-5826 |
| language | English |
| last_indexed | 2024-12-20T09:51:25Z |
| publishDate | 2016-06-01 |
| publisher | Codon Publications |
| record_format | Article |
| series | Journal of Kidney Cancer and VHL |
| spelling | doaj.art-c94e142e952d44018003a3885b81590e2022-12-21T19:44:36ZengCodon PublicationsJournal of Kidney Cancer and VHL2203-58262016-06-0132142210.15586/jkcvhl.2016.5340Multifocal Primary Neoplasms in Kidney Allografts: Evaluation of Two CasesRobert J EllisKeng Lim NgHemamali SamaratungaSharon J Del VecchioSimon T WoodGlenda C Gobe<p>Renal cell carcinoma (RCC) is the fifth most common malignancy in kidney transplant recipients, with increased risk arising due to immunosuppression. De novo RCC occurrence in kidney allografts is much less common when compared with the native kidneys. Multifocal RCC in allograft kidneys is rarely described. In this report, we discuss two cases of de novo multifocal renal neoplasms in allograft kidneys. Case 1 had three distinct neoplastic lesions of >5 mm, and case 2 had four. Using the World Health Organization 2016 classification of adult renal tumours, case 1 had one clear-cell (cc) RCC (grade 3) and two papillary adenomas; all confined to the kidney. Case 2 had a nodular lesion classified as ccRCC (grade 4) with focal rhabdoid differentiation and some infiltration of renal sinus fat; a cc tubulopapillary RCC; a multilocular cystic renal neoplasm of low malignant potential; and a mucinous tubular and spindle cell carcinoma; the last three all confined to the kidney. This is the first report of mucinous tubular and spindle cell carcinoma in a kidney allograft. When considering multifocal RCC with discordant histology, it is likely that these represent independent tumourigenic events.</p>http://jkcvhl.com/index.php/jkcvhl/article/view/53kidney cancerrenal allograftmultifocal |
| spellingShingle | Robert J Ellis Keng Lim Ng Hemamali Samaratunga Sharon J Del Vecchio Simon T Wood Glenda C Gobe Multifocal Primary Neoplasms in Kidney Allografts: Evaluation of Two Cases Journal of Kidney Cancer and VHL kidney cancer renal allograft multifocal |
| title | Multifocal Primary Neoplasms in Kidney Allografts: Evaluation of Two Cases |
| title_full | Multifocal Primary Neoplasms in Kidney Allografts: Evaluation of Two Cases |
| title_fullStr | Multifocal Primary Neoplasms in Kidney Allografts: Evaluation of Two Cases |
| title_full_unstemmed | Multifocal Primary Neoplasms in Kidney Allografts: Evaluation of Two Cases |
| title_short | Multifocal Primary Neoplasms in Kidney Allografts: Evaluation of Two Cases |
| title_sort | multifocal primary neoplasms in kidney allografts evaluation of two cases |
| topic | kidney cancer renal allograft multifocal |
| url | http://jkcvhl.com/index.php/jkcvhl/article/view/53 |
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