Impact of SIV infection on mycobacterial lipid-reactive T cell responses in Bacillus Calmette-Guérin (BCG) inoculated macaques

Impact of SIV infection on mycobacterial lipid-reactive T cell responses in Bacillus Calmette-Guérin (BCG) inoculated macaques

BackgroundAlthough BCG vaccine protects infants from tuberculosis (TB), it has limited efficacy in adults against pulmonary TB. Further, HIV coinfection significantly increases the risk of developing active TB. In the lack of defined correlates of protection in TB disease, it is essential to explore...

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Bibliographic Details
Main Authors: Edith M. Walker, Kristen M. Merino, Nadia Slisarenko, Brooke F. Grasperge, Smriti Mehra, Chad J. Roy, Deepak Kaushal, Namita Rout
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
BCG
SIV
lipid antigen
γδT
tuberculosis
macaque
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1085786/full

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