L-Ascorbic Acid Restricts <i>Vibrio cholerae</i> Survival in Various Growth Conditions
Cholera, a deadly diarrheal disease, continues to ravage various parts of the world. It is caused by <i>Vibrio cholerae</i>, an important member of the gamma-proteobacteria. Based on certain genetic and phenotypic tests, the organism is classified into two major biotypes, namely classica...
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MDPI AG
2024-02-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/12/3/492 |
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| author | Himanshu Sen Manpreet Kaur Saumya Ray Chaudhuri |
| author_facet | Himanshu Sen Manpreet Kaur Saumya Ray Chaudhuri |
| author_sort | Himanshu Sen |
| collection | DOAJ |
| description | Cholera, a deadly diarrheal disease, continues to ravage various parts of the world. It is caused by <i>Vibrio cholerae</i>, an important member of the gamma-proteobacteria. Based on certain genetic and phenotypic tests, the organism is classified into two major biotypes, namely classical and El Tor. The El Tor and its variants are majorly responsible for the ongoing seventh pandemic across the globe. Previously, we have shown that cross-feeding of glucose metabolic acidic by-products of gut commensals can severely affect the viability of the biotypes. In this work, we examined the effect of L-ascorbic acid on the survival of <i>Vibrio cholerae</i> strains belonging to both biotypes and different serotypes. We observed that L-ascorbic acid effectively restricts the growth of all strains under various conditions including strains adapted to acid stress. In addition, L-ascorbic acid is also effective in decreasing bile-induced biofilms of <i>Vibrio cholerae</i>. |
| first_indexed | 2024-04-24T18:00:51Z |
| format | Article |
| id | doaj.art-c950f71167d84a8e98eb631229574c6f |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-04-24T18:00:51Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-c950f71167d84a8e98eb631229574c6f2024-03-27T13:55:37ZengMDPI AGMicroorganisms2076-26072024-02-0112349210.3390/microorganisms12030492L-Ascorbic Acid Restricts <i>Vibrio cholerae</i> Survival in Various Growth ConditionsHimanshu Sen0Manpreet Kaur1Saumya Ray Chaudhuri2CSIR-Institute of Microbial Technology, Sector 39A, Chandigarh 160036, IndiaCSIR-Institute of Microbial Technology, Sector 39A, Chandigarh 160036, IndiaCSIR-Institute of Microbial Technology, Sector 39A, Chandigarh 160036, IndiaCholera, a deadly diarrheal disease, continues to ravage various parts of the world. It is caused by <i>Vibrio cholerae</i>, an important member of the gamma-proteobacteria. Based on certain genetic and phenotypic tests, the organism is classified into two major biotypes, namely classical and El Tor. The El Tor and its variants are majorly responsible for the ongoing seventh pandemic across the globe. Previously, we have shown that cross-feeding of glucose metabolic acidic by-products of gut commensals can severely affect the viability of the biotypes. In this work, we examined the effect of L-ascorbic acid on the survival of <i>Vibrio cholerae</i> strains belonging to both biotypes and different serotypes. We observed that L-ascorbic acid effectively restricts the growth of all strains under various conditions including strains adapted to acid stress. In addition, L-ascorbic acid is also effective in decreasing bile-induced biofilms of <i>Vibrio cholerae</i>.https://www.mdpi.com/2076-2607/12/3/492<i>Vibrio cholerae</i>L-ascorbic acidbile saltsbiofilmacetoin |
| spellingShingle | Himanshu Sen Manpreet Kaur Saumya Ray Chaudhuri L-Ascorbic Acid Restricts <i>Vibrio cholerae</i> Survival in Various Growth Conditions Microorganisms <i>Vibrio cholerae</i> L-ascorbic acid bile salts biofilm acetoin |
| title | L-Ascorbic Acid Restricts <i>Vibrio cholerae</i> Survival in Various Growth Conditions |
| title_full | L-Ascorbic Acid Restricts <i>Vibrio cholerae</i> Survival in Various Growth Conditions |
| title_fullStr | L-Ascorbic Acid Restricts <i>Vibrio cholerae</i> Survival in Various Growth Conditions |
| title_full_unstemmed | L-Ascorbic Acid Restricts <i>Vibrio cholerae</i> Survival in Various Growth Conditions |
| title_short | L-Ascorbic Acid Restricts <i>Vibrio cholerae</i> Survival in Various Growth Conditions |
| title_sort | l ascorbic acid restricts i vibrio cholerae i survival in various growth conditions |
| topic | <i>Vibrio cholerae</i> L-ascorbic acid bile salts biofilm acetoin |
| url | https://www.mdpi.com/2076-2607/12/3/492 |
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