Sclerostin decreases in regular swimmers after ice swimming and is associated with meteorin-like protein serum levels
Introduction: Cold and exercise are two important stimuli affecting the secretion of osteokines and adipomyokines, which often occur simultaneously. However, few studies have investigated the changes in osteokines and adipomyokines induced by exercise during severe cold and their corresponding assoc...
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| Format: | Article |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1210457/full |
| _version_ | 1797795134815862784 |
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| author | Shuai Mu Chongjun Huang Bobo Chen Pengyu Zhao Haoran Xu Weihao Zhang Huixu Dai |
| author_facet | Shuai Mu Chongjun Huang Bobo Chen Pengyu Zhao Haoran Xu Weihao Zhang Huixu Dai |
| author_sort | Shuai Mu |
| collection | DOAJ |
| description | Introduction: Cold and exercise are two important stimuli affecting the secretion of osteokines and adipomyokines, which often occur simultaneously. However, few studies have investigated the changes in osteokines and adipomyokines induced by exercise during severe cold and their corresponding associations. Therefore, this study aimed to investigate the changes in sclerostin and meteorin-like (metrnl) protein before and after cold exercise (ice swimming [IS]) and observe their correlation.Methods: For this, 56 daily ice swimmers’ data were included in this study. Serum sclerostin and metrnl were measured 30 min before IS and 30 min after. The fat mass, visceral fat area, fat-free mass, skeletal muscle mass, lumbar spine, and femoral neck bone mineral density of the ice swimmers were measured.Results: After IS, sclerostin exhibited significant decreases, whereas metrnl showed no significant change. In addition, the baseline level of sclerostin and the decrease in sclerostin were positively correlated with serum metrnl after adjusting for age, gender, and body composition indicators.Discussion: IS caused a significant decrease in sclerostin but did not affect metrnl. Furthermore, the associations between sclerostin and metrnl suggested a correlation between osteokines and adipomyokines; this encourages future exploration of the interconnection between bone, muscle, and fat, which will be beneficial for identifying potential common therapeutic targets for diseases such as osteoporosis, sarcopenia, and obesity. |
| first_indexed | 2024-03-13T03:13:20Z |
| format | Article |
| id | doaj.art-c9545f5a05714effa5ca23267f4588dc |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-03-13T03:13:20Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-c9545f5a05714effa5ca23267f4588dc2023-06-26T10:16:34ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-06-011410.3389/fphys.2023.12104571210457Sclerostin decreases in regular swimmers after ice swimming and is associated with meteorin-like protein serum levelsShuai Mu0Chongjun Huang1Bobo Chen2Pengyu Zhao3Haoran Xu4Weihao Zhang5Huixu Dai6Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, ChinaIntroduction: Cold and exercise are two important stimuli affecting the secretion of osteokines and adipomyokines, which often occur simultaneously. However, few studies have investigated the changes in osteokines and adipomyokines induced by exercise during severe cold and their corresponding associations. Therefore, this study aimed to investigate the changes in sclerostin and meteorin-like (metrnl) protein before and after cold exercise (ice swimming [IS]) and observe their correlation.Methods: For this, 56 daily ice swimmers’ data were included in this study. Serum sclerostin and metrnl were measured 30 min before IS and 30 min after. The fat mass, visceral fat area, fat-free mass, skeletal muscle mass, lumbar spine, and femoral neck bone mineral density of the ice swimmers were measured.Results: After IS, sclerostin exhibited significant decreases, whereas metrnl showed no significant change. In addition, the baseline level of sclerostin and the decrease in sclerostin were positively correlated with serum metrnl after adjusting for age, gender, and body composition indicators.Discussion: IS caused a significant decrease in sclerostin but did not affect metrnl. Furthermore, the associations between sclerostin and metrnl suggested a correlation between osteokines and adipomyokines; this encourages future exploration of the interconnection between bone, muscle, and fat, which will be beneficial for identifying potential common therapeutic targets for diseases such as osteoporosis, sarcopenia, and obesity.https://www.frontiersin.org/articles/10.3389/fphys.2023.1210457/fullsclerostinmetrnlosteokineadipomyokineexercisecold exposure |
| spellingShingle | Shuai Mu Chongjun Huang Bobo Chen Pengyu Zhao Haoran Xu Weihao Zhang Huixu Dai Sclerostin decreases in regular swimmers after ice swimming and is associated with meteorin-like protein serum levels Frontiers in Physiology sclerostin metrnl osteokine adipomyokine exercise cold exposure |
| title | Sclerostin decreases in regular swimmers after ice swimming and is associated with meteorin-like protein serum levels |
| title_full | Sclerostin decreases in regular swimmers after ice swimming and is associated with meteorin-like protein serum levels |
| title_fullStr | Sclerostin decreases in regular swimmers after ice swimming and is associated with meteorin-like protein serum levels |
| title_full_unstemmed | Sclerostin decreases in regular swimmers after ice swimming and is associated with meteorin-like protein serum levels |
| title_short | Sclerostin decreases in regular swimmers after ice swimming and is associated with meteorin-like protein serum levels |
| title_sort | sclerostin decreases in regular swimmers after ice swimming and is associated with meteorin like protein serum levels |
| topic | sclerostin metrnl osteokine adipomyokine exercise cold exposure |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1210457/full |
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