Mesenchymal stem cells and dental implant osseointegration during aging: from mechanisms to therapy
Abstract Dental implants are widely used to replace missing teeth, providing patients with unparalleled levels of effectiveness, convenience, and affordability. The biological basis for the clinical success of dental implants is osseointegration. Bone aging is a high-risk factor for the reduced osse...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-12-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-023-03611-1 |
| _version_ | 1797377160129806336 |
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| author | Yang Ma Siyuan Wang Hui Wang Xiaoyu Chen Yi Shuai Huiming Wang Yingjie Mao Fuming He |
| author_facet | Yang Ma Siyuan Wang Hui Wang Xiaoyu Chen Yi Shuai Huiming Wang Yingjie Mao Fuming He |
| author_sort | Yang Ma |
| collection | DOAJ |
| description | Abstract Dental implants are widely used to replace missing teeth, providing patients with unparalleled levels of effectiveness, convenience, and affordability. The biological basis for the clinical success of dental implants is osseointegration. Bone aging is a high-risk factor for the reduced osseointegration and survival rates of dental implants. In aged individuals, mesenchymal stem cells (MSCs) in the bone marrow show imbalanced differentiation with a reduction in osteogenesis and an increase in adipogenesis. This leads to impaired osseointegration and implant failure. This review focuses on the molecular mechanisms underlying the dysfunctional differentiation of aged MSCs, which primarily include autophagy, transcription factors, extracellular vesicle secretion, signaling pathways, epigenetic modifications, microRNAs, and oxidative stress. Furthermore, this review addresses the pathological changes in MSCs that affect osseointegration and discusses potential therapeutic interventions to enhance osseointegration by manipulating the mechanisms underlying MSC aging. |
| first_indexed | 2024-03-08T19:49:40Z |
| format | Article |
| id | doaj.art-c9564191fe1743aea79364522884fa70 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-03-08T19:49:40Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-c9564191fe1743aea79364522884fa702023-12-24T12:11:17ZengBMCStem Cell Research & Therapy1757-65122023-12-0114111410.1186/s13287-023-03611-1Mesenchymal stem cells and dental implant osseointegration during aging: from mechanisms to therapyYang Ma0Siyuan Wang1Hui Wang2Xiaoyu Chen3Yi Shuai4Huiming Wang5Yingjie Mao6Fuming He7Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang UniversityStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang UniversityStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang UniversityStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang UniversityNanjing Jinling Hospital: East Region Military Command General HospitalStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang UniversityStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang UniversityStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang UniversityAbstract Dental implants are widely used to replace missing teeth, providing patients with unparalleled levels of effectiveness, convenience, and affordability. The biological basis for the clinical success of dental implants is osseointegration. Bone aging is a high-risk factor for the reduced osseointegration and survival rates of dental implants. In aged individuals, mesenchymal stem cells (MSCs) in the bone marrow show imbalanced differentiation with a reduction in osteogenesis and an increase in adipogenesis. This leads to impaired osseointegration and implant failure. This review focuses on the molecular mechanisms underlying the dysfunctional differentiation of aged MSCs, which primarily include autophagy, transcription factors, extracellular vesicle secretion, signaling pathways, epigenetic modifications, microRNAs, and oxidative stress. Furthermore, this review addresses the pathological changes in MSCs that affect osseointegration and discusses potential therapeutic interventions to enhance osseointegration by manipulating the mechanisms underlying MSC aging.https://doi.org/10.1186/s13287-023-03611-1AgingOsseointegrationMesenchymal stem cellsDifferentiationMolecular mechanism |
| spellingShingle | Yang Ma Siyuan Wang Hui Wang Xiaoyu Chen Yi Shuai Huiming Wang Yingjie Mao Fuming He Mesenchymal stem cells and dental implant osseointegration during aging: from mechanisms to therapy Stem Cell Research & Therapy Aging Osseointegration Mesenchymal stem cells Differentiation Molecular mechanism |
| title | Mesenchymal stem cells and dental implant osseointegration during aging: from mechanisms to therapy |
| title_full | Mesenchymal stem cells and dental implant osseointegration during aging: from mechanisms to therapy |
| title_fullStr | Mesenchymal stem cells and dental implant osseointegration during aging: from mechanisms to therapy |
| title_full_unstemmed | Mesenchymal stem cells and dental implant osseointegration during aging: from mechanisms to therapy |
| title_short | Mesenchymal stem cells and dental implant osseointegration during aging: from mechanisms to therapy |
| title_sort | mesenchymal stem cells and dental implant osseointegration during aging from mechanisms to therapy |
| topic | Aging Osseointegration Mesenchymal stem cells Differentiation Molecular mechanism |
| url | https://doi.org/10.1186/s13287-023-03611-1 |
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