Cytokines (IL1β, IL6, TNFα) and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19
Background: Post-acute sequelae of COVID-19 (PASC) comprise a broad spectrum of symptoms such as fatigue, general weakness, compromised attention and sleep or anxiety disorders. PASC represents a medical and socio-economic challenge. Objectives: Our study evaluated cytokines (IL-1β, IL-6 and TNFα) a...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2024-02-01
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| Series: | Therapeutic Advances in Neurological Disorders |
| Online Access: | https://doi.org/10.1177/17562864241229567 |
| _version_ | 1827353170131550208 |
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| author | Michael Fleischer Fabian Szepanowski Anne K Mausberg Livia Asan Ellen Uslar Denise Zwanziger Lothar Volbracht Mark Stettner Christoph Kleinschnitz |
| author_facet | Michael Fleischer Fabian Szepanowski Anne K Mausberg Livia Asan Ellen Uslar Denise Zwanziger Lothar Volbracht Mark Stettner Christoph Kleinschnitz |
| author_sort | Michael Fleischer |
| collection | DOAJ |
| description | Background: Post-acute sequelae of COVID-19 (PASC) comprise a broad spectrum of symptoms such as fatigue, general weakness, compromised attention and sleep or anxiety disorders. PASC represents a medical and socio-economic challenge. Objectives: Our study evaluated cytokines (IL-1β, IL-6 and TNFα) and cortisol levels in a cohort of typical patients with PASC, suffering concentration problems, fatigue and difficulties finding words. Design: This was a prospective cohort study. Four groups were analysed and compared: those who had never contracted SARS-CoV-2 ( n = 13), infected but had no PASC ( n = 34), infected with former PASC that resolved ( n = 40) and patients with ongoing PASC after infection ( n = 91). Methods: Cytokine and cortisol serum levels were determined in patients’ blood samples. Results: Cytokine levels of IL-1β, IL-6, TNFα and cortisol levels did not differ between groups analysed. Conclusion: This may indicate a non-organic/psychosomatic genesis of PASC; further studies are needed to elucidate the underlying causes of PACS, and non-organic causes should not be overlooked. |
| first_indexed | 2024-03-08T03:20:55Z |
| format | Article |
| id | doaj.art-c958388076424f859fbaa522dff4f5a3 |
| institution | Directory Open Access Journal |
| issn | 1756-2864 |
| language | English |
| last_indexed | 2024-03-08T03:20:55Z |
| publishDate | 2024-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Neurological Disorders |
| spelling | doaj.art-c958388076424f859fbaa522dff4f5a32024-02-12T10:03:36ZengSAGE PublishingTherapeutic Advances in Neurological Disorders1756-28642024-02-011710.1177/17562864241229567Cytokines (IL1β, IL6, TNFα) and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19Michael FleischerFabian SzepanowskiAnne K MausbergLivia AsanEllen UslarDenise ZwanzigerLothar VolbrachtMark StettnerChristoph KleinschnitzBackground: Post-acute sequelae of COVID-19 (PASC) comprise a broad spectrum of symptoms such as fatigue, general weakness, compromised attention and sleep or anxiety disorders. PASC represents a medical and socio-economic challenge. Objectives: Our study evaluated cytokines (IL-1β, IL-6 and TNFα) and cortisol levels in a cohort of typical patients with PASC, suffering concentration problems, fatigue and difficulties finding words. Design: This was a prospective cohort study. Four groups were analysed and compared: those who had never contracted SARS-CoV-2 ( n = 13), infected but had no PASC ( n = 34), infected with former PASC that resolved ( n = 40) and patients with ongoing PASC after infection ( n = 91). Methods: Cytokine and cortisol serum levels were determined in patients’ blood samples. Results: Cytokine levels of IL-1β, IL-6, TNFα and cortisol levels did not differ between groups analysed. Conclusion: This may indicate a non-organic/psychosomatic genesis of PASC; further studies are needed to elucidate the underlying causes of PACS, and non-organic causes should not be overlooked.https://doi.org/10.1177/17562864241229567 |
| spellingShingle | Michael Fleischer Fabian Szepanowski Anne K Mausberg Livia Asan Ellen Uslar Denise Zwanziger Lothar Volbracht Mark Stettner Christoph Kleinschnitz Cytokines (IL1β, IL6, TNFα) and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19 Therapeutic Advances in Neurological Disorders |
| title | Cytokines (IL1β, IL6, TNFα) and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19 |
| title_full | Cytokines (IL1β, IL6, TNFα) and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19 |
| title_fullStr | Cytokines (IL1β, IL6, TNFα) and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19 |
| title_full_unstemmed | Cytokines (IL1β, IL6, TNFα) and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19 |
| title_short | Cytokines (IL1β, IL6, TNFα) and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19 |
| title_sort | cytokines il1β il6 tnfα and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post acute sequelae of covid 19 |
| url | https://doi.org/10.1177/17562864241229567 |
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