A method for the efficient evaluation of substrate-based cholinesterase imaging probes for Alzheimer’s disease

A method for the efficient evaluation of substrate-based cholinesterase imaging probes for Alzheimer’s disease

AbstractCholinesterase (ChE) enzymes have been identified as diagnostic markers for Alzheimer disease (AD). Substrate-based probes have been synthesised to detect ChEs but they have not detected changes in ChE distribution associated with AD pathology. Probes are typically screened using spectrophot...

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Bibliographic Details
Main Authors: Sultan Darvesh, Scott Banfield, Maeve Dufour, Katrina L. Forrestall, Hillary Maillet, G. Andrew Reid, Dane Sands, Ian R. Pottie
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Butyrylcholinesterase
acetylcholinesterase
Alzheimer’s disease
neuroimaging
radioligands
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2023.2225797

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