Association between Sarcopenic Obesity Status and Nonalcoholic Fatty Liver Disease and Fibrosis
Background/Aims: There are no data regarding the association between sarcopenic obesity status and nonalcoholic fatty liver disease (NAFLD) and NAFLD-associated liver fibrosis. Therefore, we aimed to investigate the relationship between sarcopenic obesity status (sarcopenia only, obesity only, and s...
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| Aineistotyyppi: | Artikkeli |
| Kieli: | English |
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Gastroenterology Council for Gut and Liver
2023-01-01
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| Sarja: | Gut and Liver |
| Aiheet: | |
| Linkit: | http://gutnliver.org/journal/view.html?doi=10.5009/gnl220041 |
| _version_ | 1827257290825138176 |
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| author | Wolhwa Song Sung Hwan Yoo Jinsun Jang Su Jung Baik Byoung Kwon Lee Hyun Woong Lee Jong Suk Park |
| author_facet | Wolhwa Song Sung Hwan Yoo Jinsun Jang Su Jung Baik Byoung Kwon Lee Hyun Woong Lee Jong Suk Park |
| author_sort | Wolhwa Song |
| collection | DOAJ |
| description | Background/Aims: There are no data regarding the association between sarcopenic obesity status and nonalcoholic fatty liver disease (NAFLD) and NAFLD-associated liver fibrosis. Therefore, we aimed to investigate the relationship between sarcopenic obesity status (sarcopenia only, obesity only, and sarcopenic obesity) and NAFLD and liver fibrosis in Korean adults.Methods: In total, 2,191 subjects completed a health checkup program, including abdominal ultrasonography and FibroScan. Subjects were classified into the following four categories: optimal body composition (nonobese and nonsarcopenic), sarcopenia only (nonobese), obesity only (nonsarcopenic), and sarcopenic obesity. Sarcopenic obesity was stratified by the skeletal muscle mass index and body fat using bioelectrical impedance analysis. NAFLD was diagnosed by ultrasonography, and liver fibrosis was assessed using transient elastography in subjects with NAFLD.Results: The prevalence of NAFLD and liver fibrosis significantly increased according to the sarcopenic obesity status. In the logistic regression analysis, after adjusting for multiple risk factors, the odds ratio (OR) for the risk of NAFLD was largest in the sarcopenic obesity group (OR, 3.68; 95% confidence interval [CI], 2.94 to 4.60), followed by the obesity only (OR, 2.25; 95% CI, 1.67 to 3.03) and sarcopenia only (OR, 1.92; 95% CI, 1.30 to 2.84) groups, when compared with the optimal group. Additionally, liver fibrosis was independently associated with sarcopenic obesity status (OR 4.69, 95% CI 1.95 to 11.29; OR 4.17, 95% CI 1.56 to 11.17; OR 3.80, 95% CI 0.86 to 16.75, respectively).Conclusions: These results demonstrated that sarcopenic obesity was independently associated with NAFLD and liver fibrosis and increased the risk of NAFLD and liver fibrosis more than obesity or sarcopenia alone. |
| first_indexed | 2025-03-22T01:52:27Z |
| format | Article |
| id | doaj.art-c95a20f75f554b51a18178ee75b7fdd4 |
| institution | Directory Open Access Journal |
| issn | 1976-2283 |
| language | English |
| last_indexed | 2025-03-22T01:52:27Z |
| publishDate | 2023-01-01 |
| publisher | Gastroenterology Council for Gut and Liver |
| record_format | Article |
| series | Gut and Liver |
| spelling | doaj.art-c95a20f75f554b51a18178ee75b7fdd42024-05-08T02:33:00ZengGastroenterology Council for Gut and LiverGut and Liver1976-22832023-01-0117113013810.5009/gnl220041gnl220041Association between Sarcopenic Obesity Status and Nonalcoholic Fatty Liver Disease and FibrosisWolhwa Song0Sung Hwan Yoo1Jinsun Jang2Su Jung Baik3Byoung Kwon Lee4Hyun Woong Lee5Jong Suk Park6Divisions of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, KoreaDivisions of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, KoreaDivisions of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, KoreaHealthcare Research Team, Health Promotion Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, KoreaHealthcare Research Team, Health Promotion Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, KoreaDivisions of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, KoreaDivisions of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, KoreaBackground/Aims: There are no data regarding the association between sarcopenic obesity status and nonalcoholic fatty liver disease (NAFLD) and NAFLD-associated liver fibrosis. Therefore, we aimed to investigate the relationship between sarcopenic obesity status (sarcopenia only, obesity only, and sarcopenic obesity) and NAFLD and liver fibrosis in Korean adults.Methods: In total, 2,191 subjects completed a health checkup program, including abdominal ultrasonography and FibroScan. Subjects were classified into the following four categories: optimal body composition (nonobese and nonsarcopenic), sarcopenia only (nonobese), obesity only (nonsarcopenic), and sarcopenic obesity. Sarcopenic obesity was stratified by the skeletal muscle mass index and body fat using bioelectrical impedance analysis. NAFLD was diagnosed by ultrasonography, and liver fibrosis was assessed using transient elastography in subjects with NAFLD.Results: The prevalence of NAFLD and liver fibrosis significantly increased according to the sarcopenic obesity status. In the logistic regression analysis, after adjusting for multiple risk factors, the odds ratio (OR) for the risk of NAFLD was largest in the sarcopenic obesity group (OR, 3.68; 95% confidence interval [CI], 2.94 to 4.60), followed by the obesity only (OR, 2.25; 95% CI, 1.67 to 3.03) and sarcopenia only (OR, 1.92; 95% CI, 1.30 to 2.84) groups, when compared with the optimal group. Additionally, liver fibrosis was independently associated with sarcopenic obesity status (OR 4.69, 95% CI 1.95 to 11.29; OR 4.17, 95% CI 1.56 to 11.17; OR 3.80, 95% CI 0.86 to 16.75, respectively).Conclusions: These results demonstrated that sarcopenic obesity was independently associated with NAFLD and liver fibrosis and increased the risk of NAFLD and liver fibrosis more than obesity or sarcopenia alone.http://gutnliver.org/journal/view.html?doi=10.5009/gnl220041obesitynon-alcoholic fatty liver diseaseliver fibrosis |
| spellingShingle | Wolhwa Song Sung Hwan Yoo Jinsun Jang Su Jung Baik Byoung Kwon Lee Hyun Woong Lee Jong Suk Park Association between Sarcopenic Obesity Status and Nonalcoholic Fatty Liver Disease and Fibrosis Gut and Liver obesity non-alcoholic fatty liver disease liver fibrosis |
| title | Association between Sarcopenic Obesity Status and Nonalcoholic Fatty Liver Disease and Fibrosis |
| title_full | Association between Sarcopenic Obesity Status and Nonalcoholic Fatty Liver Disease and Fibrosis |
| title_fullStr | Association between Sarcopenic Obesity Status and Nonalcoholic Fatty Liver Disease and Fibrosis |
| title_full_unstemmed | Association between Sarcopenic Obesity Status and Nonalcoholic Fatty Liver Disease and Fibrosis |
| title_short | Association between Sarcopenic Obesity Status and Nonalcoholic Fatty Liver Disease and Fibrosis |
| title_sort | association between sarcopenic obesity status and nonalcoholic fatty liver disease and fibrosis |
| topic | obesity non-alcoholic fatty liver disease liver fibrosis |
| url | http://gutnliver.org/journal/view.html?doi=10.5009/gnl220041 |
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