Usefulness of sennoside as an agent for mechanical bowel preparation prior to elective colon cancer surgery
Objective: We retrospectively evaluated the usefulness of sennoside as an agent for mechanical bowel preparation prior to elective colon cancer surgery. Methods: A total of 86 patients were given 12 mg of sennoside on the evening prior to resective surgery for colon cancer, followed by intravenous a...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2012-04-01
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| Series: | Asian Journal of Surgery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958412000425 |
| _version_ | 1818984440389435392 |
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| author | Keiichiro Ishibashi Kensuke Kumamoto Kouki Kuwabara Naoko Hokama Toru Ishiguro Tomonori Ohsawa Norimichi Okada Tatsuya Miyazaki Masaru Yokoyama Yoshitaka Tsuji Norihiro Haga Hideyuki Ishida |
| author_facet | Keiichiro Ishibashi Kensuke Kumamoto Kouki Kuwabara Naoko Hokama Toru Ishiguro Tomonori Ohsawa Norimichi Okada Tatsuya Miyazaki Masaru Yokoyama Yoshitaka Tsuji Norihiro Haga Hideyuki Ishida |
| author_sort | Keiichiro Ishibashi |
| collection | DOAJ |
| description | Objective: We retrospectively evaluated the usefulness of sennoside as an agent for mechanical bowel preparation prior to elective colon cancer surgery.
Methods: A total of 86 patients were given 12 mg of sennoside on the evening prior to resective surgery for colon cancer, followed by intravenous antimicrobial prophylaxis used on the day of surgery or until postoperative day 2.
Results: The incidence of surgical site infection in the study group was 4.7%, which was comparable to that in the historical control patients (3.5%, p>0.99), who had received polyethylene glycol for mechanical bowel preparation prior to colon surgery. On multivariate logistic regression analysis, only body mass index (p=0.04) was an independent significant factor affecting the surgical site infection. The intraoperative spillage was not influenced by the presence of stenosis, although the amount of fecal matter was higher in the upstream colon segment (p<0.01) and downstream segment (p=0.07) in patients with a stenotic lesion occupying more than two-thirds of the lumen (n=29) than in those without such severe stenosis (n=57).
Conclusion: Sennoside seems to be an acceptable agent for mechanical bowel preparation even in patients with stenosis. |
| first_indexed | 2024-12-20T18:19:02Z |
| format | Article |
| id | doaj.art-c95f230c5ced4dd58729155460433a85 |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-12-20T18:19:02Z |
| publishDate | 2012-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-c95f230c5ced4dd58729155460433a852022-12-21T19:30:17ZengElsevierAsian Journal of Surgery1015-95842012-04-01352818710.1016/j.asjsur.2012.04.022Usefulness of sennoside as an agent for mechanical bowel preparation prior to elective colon cancer surgeryKeiichiro IshibashiKensuke KumamotoKouki KuwabaraNaoko HokamaToru IshiguroTomonori OhsawaNorimichi OkadaTatsuya MiyazakiMasaru YokoyamaYoshitaka TsujiNorihiro HagaHideyuki IshidaObjective: We retrospectively evaluated the usefulness of sennoside as an agent for mechanical bowel preparation prior to elective colon cancer surgery. Methods: A total of 86 patients were given 12 mg of sennoside on the evening prior to resective surgery for colon cancer, followed by intravenous antimicrobial prophylaxis used on the day of surgery or until postoperative day 2. Results: The incidence of surgical site infection in the study group was 4.7%, which was comparable to that in the historical control patients (3.5%, p>0.99), who had received polyethylene glycol for mechanical bowel preparation prior to colon surgery. On multivariate logistic regression analysis, only body mass index (p=0.04) was an independent significant factor affecting the surgical site infection. The intraoperative spillage was not influenced by the presence of stenosis, although the amount of fecal matter was higher in the upstream colon segment (p<0.01) and downstream segment (p=0.07) in patients with a stenotic lesion occupying more than two-thirds of the lumen (n=29) than in those without such severe stenosis (n=57). Conclusion: Sennoside seems to be an acceptable agent for mechanical bowel preparation even in patients with stenosis.http://www.sciencedirect.com/science/article/pii/S1015958412000425bowel preparationcolon cancersennosidesurgical site infection |
| spellingShingle | Keiichiro Ishibashi Kensuke Kumamoto Kouki Kuwabara Naoko Hokama Toru Ishiguro Tomonori Ohsawa Norimichi Okada Tatsuya Miyazaki Masaru Yokoyama Yoshitaka Tsuji Norihiro Haga Hideyuki Ishida Usefulness of sennoside as an agent for mechanical bowel preparation prior to elective colon cancer surgery Asian Journal of Surgery bowel preparation colon cancer sennoside surgical site infection |
| title | Usefulness of sennoside as an agent for mechanical bowel preparation prior to elective colon cancer surgery |
| title_full | Usefulness of sennoside as an agent for mechanical bowel preparation prior to elective colon cancer surgery |
| title_fullStr | Usefulness of sennoside as an agent for mechanical bowel preparation prior to elective colon cancer surgery |
| title_full_unstemmed | Usefulness of sennoside as an agent for mechanical bowel preparation prior to elective colon cancer surgery |
| title_short | Usefulness of sennoside as an agent for mechanical bowel preparation prior to elective colon cancer surgery |
| title_sort | usefulness of sennoside as an agent for mechanical bowel preparation prior to elective colon cancer surgery |
| topic | bowel preparation colon cancer sennoside surgical site infection |
| url | http://www.sciencedirect.com/science/article/pii/S1015958412000425 |
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