Flow-mediated dilation can be used to predict incident hypertension in patients with hyperuricemia
Introduction The aim of the study was to evaluate whether flow-mediated dilation (FMD) can be used to predict incident hypertension in patients with hyperuricemia. Material and methods Normotensive participants with and without hyperuricemia at baseline were prospectively enrolled. Flow-mediated di...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2019-03-01
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| Series: | Archives of Medical Science |
| Subjects: | |
| Online Access: | https://www.archivesofmedicalscience.com/Flow-mediated-dilation-can-be-used-to-predict-incident-hypertension-in-patients-with,81637,0,2.html |
| _version_ | 1828975375261106176 |
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| author | Chunli Han Zhanchao Xian Yang Zou Zhiyong Liao Rongfeng Yang Chunxia Zou Xiaoqing Wang Yan Sun |
| author_facet | Chunli Han Zhanchao Xian Yang Zou Zhiyong Liao Rongfeng Yang Chunxia Zou Xiaoqing Wang Yan Sun |
| author_sort | Chunli Han |
| collection | DOAJ |
| description | Introduction
The aim of the study was to evaluate whether flow-mediated dilation (FMD) can be used to predict incident hypertension in patients with hyperuricemia.
Material and methods
Normotensive participants with and without hyperuricemia at baseline were prospectively enrolled. Flow-mediated dilation was assessed at baseline, and after 1 year’s follow-up the incidence of hypertension was compared between those with and without hyperuricemia. The predictive value of baseline FMD for incident hypertension among hyperuricemia patients was evaluated.
Results
A total of 222 participants were included. Mean systolic and diastolic blood pressure (BP) was 129.5 ±8.4 mm Hg and 78.3 ±7.9 mm Hg. Mean serum uric acid (UA) level was 4.4 ±2.8 mg/dl. Mean FMD was 5.1 ±2.7%. Compared to normal UA group, hyperuricemia group had higher proportion of male (58.4% vs. 61.2%), higher systolic BP (125.4 ±7.9 mm Hg vs. 132.1 ±7.3 mm Hg), serum high sensitivity C-reactive protein (3.9 ±2.2 mg/dl vs. 4.5 ±3.0 mg/dl) and UA (3.5 ±1.4 mg/dl vs. 5.7 ±0.7 mg/dl) levels, but lower mean FMD (5.6 ±2.4% vs. 4.8 ±2.0%) (p < 0.05 for all comparisons). No participant in normal UA group developed hypertension, while in hyperuricemia group, 6 participants developed hypertension. In hyperuricemia participants, after adjusted for covariates, per 1-standard deviation decrease in baseline FMD remained significantly associated with 15% increased risk of incident hypertension.
Conclusions
Patients with hyperuricemia have an increased risk of developing hypertension, and low baseline FMD in hyperuricemia patients is associated with significantly increased risk of incident hypertension. |
| first_indexed | 2024-12-14T14:20:02Z |
| format | Article |
| id | doaj.art-c95fa6fb0ac2467e8b483cda965940bc |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-12-14T14:20:02Z |
| publishDate | 2019-03-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-c95fa6fb0ac2467e8b483cda965940bc2022-12-21T22:58:07ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512019-03-0115234334910.5114/aoms.2018.7385681637Flow-mediated dilation can be used to predict incident hypertension in patients with hyperuricemiaChunli Han0Zhanchao Xian1Yang Zou2Zhiyong Liao3Rongfeng Yang4Chunxia Zou5Xiaoqing Wang6Yan Sun7Department of Cardiology, the Fifth Subsidiary Sun Yat-sen University Hospital, Zhuhai, ChinaDepartment of Cardiology, Shenzhen Sun Yat-sen Cardiovascular Hospital, Shenzhen, ChinaDepartment of Cardiology, Shenzhen Sun Yat-sen Cardiovascular Hospital, Shenzhen, ChinaDepartment of Cardiology, Shenzhen Sun Yat-sen Cardiovascular Hospital, Shenzhen, ChinaDepartment of Cardiology, Shenzhen Sun Yat-sen Cardiovascular Hospital, Shenzhen, ChinaDepartment of Cardiology, Shenzhen Sun Yat-sen Cardiovascular Hospital, Shenzhen, ChinaDepartment of Cardiology, Shenzhen Sun Yat-sen Cardiovascular Hospital, Shenzhen, ChinaDepartment of Endocrinology, Xili People’s Hospital of Nanshan District, Shenzhen, ChinaIntroduction The aim of the study was to evaluate whether flow-mediated dilation (FMD) can be used to predict incident hypertension in patients with hyperuricemia. Material and methods Normotensive participants with and without hyperuricemia at baseline were prospectively enrolled. Flow-mediated dilation was assessed at baseline, and after 1 year’s follow-up the incidence of hypertension was compared between those with and without hyperuricemia. The predictive value of baseline FMD for incident hypertension among hyperuricemia patients was evaluated. Results A total of 222 participants were included. Mean systolic and diastolic blood pressure (BP) was 129.5 ±8.4 mm Hg and 78.3 ±7.9 mm Hg. Mean serum uric acid (UA) level was 4.4 ±2.8 mg/dl. Mean FMD was 5.1 ±2.7%. Compared to normal UA group, hyperuricemia group had higher proportion of male (58.4% vs. 61.2%), higher systolic BP (125.4 ±7.9 mm Hg vs. 132.1 ±7.3 mm Hg), serum high sensitivity C-reactive protein (3.9 ±2.2 mg/dl vs. 4.5 ±3.0 mg/dl) and UA (3.5 ±1.4 mg/dl vs. 5.7 ±0.7 mg/dl) levels, but lower mean FMD (5.6 ±2.4% vs. 4.8 ±2.0%) (p < 0.05 for all comparisons). No participant in normal UA group developed hypertension, while in hyperuricemia group, 6 participants developed hypertension. In hyperuricemia participants, after adjusted for covariates, per 1-standard deviation decrease in baseline FMD remained significantly associated with 15% increased risk of incident hypertension. Conclusions Patients with hyperuricemia have an increased risk of developing hypertension, and low baseline FMD in hyperuricemia patients is associated with significantly increased risk of incident hypertension.https://www.archivesofmedicalscience.com/Flow-mediated-dilation-can-be-used-to-predict-incident-hypertension-in-patients-with,81637,0,2.htmlhypertensionflow-mediated dilationhyperuricemia |
| spellingShingle | Chunli Han Zhanchao Xian Yang Zou Zhiyong Liao Rongfeng Yang Chunxia Zou Xiaoqing Wang Yan Sun Flow-mediated dilation can be used to predict incident hypertension in patients with hyperuricemia Archives of Medical Science hypertension flow-mediated dilation hyperuricemia |
| title | Flow-mediated dilation can be used to predict incident hypertension in patients with hyperuricemia |
| title_full | Flow-mediated dilation can be used to predict incident hypertension in patients with hyperuricemia |
| title_fullStr | Flow-mediated dilation can be used to predict incident hypertension in patients with hyperuricemia |
| title_full_unstemmed | Flow-mediated dilation can be used to predict incident hypertension in patients with hyperuricemia |
| title_short | Flow-mediated dilation can be used to predict incident hypertension in patients with hyperuricemia |
| title_sort | flow mediated dilation can be used to predict incident hypertension in patients with hyperuricemia |
| topic | hypertension flow-mediated dilation hyperuricemia |
| url | https://www.archivesofmedicalscience.com/Flow-mediated-dilation-can-be-used-to-predict-incident-hypertension-in-patients-with,81637,0,2.html |
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