A novel small molecule, CU05-1189, targeting the pleckstrin homology domain of PDK1 suppresses VEGF-mediated angiogenesis and tumor growth by blocking the Akt signaling pathway

A novel small molecule, CU05-1189, targeting the pleckstrin homology domain of PDK1 suppresses VEGF-mediated angiogenesis and tumor growth by blocking the Akt signaling pathway

Inhibition of angiogenesis is considered a promising therapeutic approach for cancer treatment. Our previous genetic research showed that the use of a cell-penetrating peptide to inhibit the pleckstrin homology (PH) domain of 3-phosphoinositide-dependent kinase 1 (PDK1) was a viable approach to supp...

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Bibliographic Details
Main Authors: Jeongeun Park, Haiying Zhang, Hyun Jung Kwak, Changdev Gorakshnath Gadhe, Yeomyeong Kim, Hyejeong Kim, Minyoung Noh, Dongyun Shin, Sang-Jun Ha, Young-Guen Kwon
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Pharmacology
Subjects:
CU05-1189
angiogenesis
PDK1
Akt
cancer therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1275749/full

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