Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer
Abstract Cancer cells often upregulate nutrient transporters to fulfill their increased biosynthetic and bioenergetic needs, and to maintain redox homeostasis. One nutrient transporter frequently overexpressed in human cancers is the cystine/glutamate antiporter solute carrier family 7 member 11 (SL...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-04-01
|
| Series: | Cancer Communications |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40880-018-0288-x |
| _version_ | 1828258522697039872 |
|---|---|
| author | Pranavi Koppula Yilei Zhang Li Zhuang Boyi Gan |
| author_facet | Pranavi Koppula Yilei Zhang Li Zhuang Boyi Gan |
| author_sort | Pranavi Koppula |
| collection | DOAJ |
| description | Abstract Cancer cells often upregulate nutrient transporters to fulfill their increased biosynthetic and bioenergetic needs, and to maintain redox homeostasis. One nutrient transporter frequently overexpressed in human cancers is the cystine/glutamate antiporter solute carrier family 7 member 11 (SLC7A11; also known as xCT). SLC7A11 promotes cystine uptake and glutathione biosynthesis, resulting in protection from oxidative stress and ferroptotic cell death. Recent studies have unexpectedly revealed that SLC7A11 also plays critical roles in glutamine metabolism and regulates the glucose and glutamine dependency of cancer cells. This review discusses the roles of SLC7A11 in regulating the antioxidant response and nutrient dependency of cancer cells, explores our current understanding of SLC7A11 regulation in cancer metabolism, and highlights key open questions for future studies in this emerging research area. A deeper understanding of SLC7A11 in cancer metabolism may identify new therapeutic opportunities to target this important amino acid transporter for cancer treatment. |
| first_indexed | 2024-04-13T02:54:16Z |
| format | Article |
| id | doaj.art-c9658233b260472baeb0c3b6ad60a8c5 |
| institution | Directory Open Access Journal |
| issn | 2523-3548 |
| language | English |
| last_indexed | 2024-04-13T02:54:16Z |
| publishDate | 2018-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Communications |
| spelling | doaj.art-c9658233b260472baeb0c3b6ad60a8c52022-12-22T03:05:44ZengWileyCancer Communications2523-35482018-04-0138111310.1186/s40880-018-0288-xAmino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancerPranavi Koppula0Yilei Zhang1Li Zhuang2Boyi Gan3Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer CenterAbstract Cancer cells often upregulate nutrient transporters to fulfill their increased biosynthetic and bioenergetic needs, and to maintain redox homeostasis. One nutrient transporter frequently overexpressed in human cancers is the cystine/glutamate antiporter solute carrier family 7 member 11 (SLC7A11; also known as xCT). SLC7A11 promotes cystine uptake and glutathione biosynthesis, resulting in protection from oxidative stress and ferroptotic cell death. Recent studies have unexpectedly revealed that SLC7A11 also plays critical roles in glutamine metabolism and regulates the glucose and glutamine dependency of cancer cells. This review discusses the roles of SLC7A11 in regulating the antioxidant response and nutrient dependency of cancer cells, explores our current understanding of SLC7A11 regulation in cancer metabolism, and highlights key open questions for future studies in this emerging research area. A deeper understanding of SLC7A11 in cancer metabolism may identify new therapeutic opportunities to target this important amino acid transporter for cancer treatment.http://link.springer.com/article/10.1186/s40880-018-0288-xSLC7A11xCTSystem x c −CystineGlutamateFerroptosis |
| spellingShingle | Pranavi Koppula Yilei Zhang Li Zhuang Boyi Gan Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer Cancer Communications SLC7A11 xCT System x c − Cystine Glutamate Ferroptosis |
| title | Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer |
| title_full | Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer |
| title_fullStr | Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer |
| title_full_unstemmed | Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer |
| title_short | Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer |
| title_sort | amino acid transporter slc7a11 xct at the crossroads of regulating redox homeostasis and nutrient dependency of cancer |
| topic | SLC7A11 xCT System x c − Cystine Glutamate Ferroptosis |
| url | http://link.springer.com/article/10.1186/s40880-018-0288-x |
| work_keys_str_mv | AT pranavikoppula aminoacidtransporterslc7a11xctatthecrossroadsofregulatingredoxhomeostasisandnutrientdependencyofcancer AT yileizhang aminoacidtransporterslc7a11xctatthecrossroadsofregulatingredoxhomeostasisandnutrientdependencyofcancer AT lizhuang aminoacidtransporterslc7a11xctatthecrossroadsofregulatingredoxhomeostasisandnutrientdependencyofcancer AT boyigan aminoacidtransporterslc7a11xctatthecrossroadsofregulatingredoxhomeostasisandnutrientdependencyofcancer |