Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer

Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer

Abstract Cancer cells often upregulate nutrient transporters to fulfill their increased biosynthetic and bioenergetic needs, and to maintain redox homeostasis. One nutrient transporter frequently overexpressed in human cancers is the cystine/glutamate antiporter solute carrier family 7 member 11 (SL...

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Bibliographic Details
Main Authors: Pranavi Koppula, Yilei Zhang, Li Zhuang, Boyi Gan
Format: Article
Language:English
Published: Wiley 2018-04-01
Series:Cancer Communications
Subjects:
SLC7A11
xCT
System x c −
Cystine
Glutamate
Ferroptosis
Online Access:http://link.springer.com/article/10.1186/s40880-018-0288-x

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