Lipid‐Lowering Trials Are Not Representative of Patients Managed in Clinical Practice: A Systematic Review and Meta‐Analysis of Exclusion Criteria

Lipid‐Lowering Trials Are Not Representative of Patients Managed in Clinical Practice: A Systematic Review and Meta‐Analysis of Exclusion Criteria

Background Randomized clinical trials (RCTs) might not be representative of the real‐world population because of unreasonable exclusion criteria. We sought to determine which groups of patients are excluded from RCTs that included lipid‐lowering therapy. Methods and Results We retrieved all trials f...

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Bibliographic Details
Main Authors: Martina Aeschbacher‐Germann, Nathalie Kaiser, Alexandre Speierer, Manuel R. Blum, Douglas C. Bauer, Cinzia Del Giovane, Drahomir Aujesky, Baris Gencer, Nicolas Rodondi, Elisavet Moutzouri
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
exclusion criteria
external validity
generalizability
lipid trials
multimorbidity
statins
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.122.026551

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