Deciphering DSC2 arrhythmogenic cardiomyopathy electrical instability: From ion channels to ECG and tailored drug therapy

Deciphering DSC2 arrhythmogenic cardiomyopathy electrical instability: From ion channels to ECG and tailored drug therapy

Abstract Background Severe ventricular rhythm disturbances are the hallmark of arrhythmogenic cardiomyopathy (ACM), and are often explained by structural conduction abnormalities. However, comprehensive investigations of ACM cell electrical instability are lacking. This study aimed to elucidate earl...

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Bibliographic Details
Main Authors: Adrien Moreau, Jean‐Baptiste Reisqs, Helene Delanoe‐Ayari, Marion Pierre, Alexandre Janin, Antoine Deliniere, Francis Bessière, Albano C. Meli, Azzouz Charrabi, Estele Lafont, Camille Valla, Delphine Bauer, Elodie Morel, Vincent Gache, Gilles Millat, Xavier Nissan, Adele Faucherre, Chris Jopling, Sylvain Richard, Alexandre Mejat, Philippe Chevalier
Format: Article
Language:English
Published: Wiley 2021-03-01
Series:Clinical and Translational Medicine
Subjects:
action potential duration
arrhythmogenic cardiomyopathy
desmocollin
hiPSC‐CM
QT duration
Online Access:https://doi.org/10.1002/ctm2.319

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