Chemotherapy: A partnership with immunotherapy in non‐small cell lung cancer
Abstract Chemotherapy (CT) and immunotherapy (IO) act synergically in the treatment of non‐small cell lung cancer (NSCLC). However, the molecular basis of such interaction is poorly understood. The aim of this review was to explore the mechanisms of CT to potentiate the immune system and, consequent...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-02-01
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| Series: | Thoracic Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1759-7714.14779 |
| _version_ | 1811165007242592256 |
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| author | Ana Sofia Mendes Raquel Romão Joana Febra Sérgio Xavier Azevedo Paula Fidalgo António Araújo |
| author_facet | Ana Sofia Mendes Raquel Romão Joana Febra Sérgio Xavier Azevedo Paula Fidalgo António Araújo |
| author_sort | Ana Sofia Mendes |
| collection | DOAJ |
| description | Abstract Chemotherapy (CT) and immunotherapy (IO) act synergically in the treatment of non‐small cell lung cancer (NSCLC). However, the molecular basis of such interaction is poorly understood. The aim of this review was to explore the mechanisms of CT to potentiate the immune system and, consequently, the action of IO. The most up‐to‐date knowledge concerning the interaction of CT and IO in NSCLC was reviewed and a bibliographic search was made in PubMed/Medline database, using the mentioned keywords, with preference given to recently published articles in English. In addition to the direct cytotoxic effect, CT affects the immune system leading indirectly to cell death. The immune response triggered by PD‐1 inhibition is enhanced by the cytotoxic immunogenic effects of CT. This potentiation phenomenon occurs due to an increase in effector cells relatively to regulatory cells, inhibition of myeloid derived suppressor cells, increased potential for cross‐presentation by dendritic cells after the death of tumor cells or blocking the STAT6 pathway to increase dendritic cell activity. In conclusion, the effects of CT on the immune system work in synergy with the actions of IO, transforming “cold” tumors into “hot” tumors, which are more visible to the immune system. |
| first_indexed | 2024-04-10T15:30:37Z |
| format | Article |
| id | doaj.art-c966a495b81147b98f0fa7a3649ac9f9 |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-04-10T15:30:37Z |
| publishDate | 2023-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-c966a495b81147b98f0fa7a3649ac9f92023-02-14T02:01:34ZengWileyThoracic Cancer1759-77061759-77142023-02-0114543744110.1111/1759-7714.14779Chemotherapy: A partnership with immunotherapy in non‐small cell lung cancerAna Sofia Mendes0Raquel Romão1Joana Febra2Sérgio Xavier Azevedo3Paula Fidalgo4António Araújo5Medical Oncology Department Centro Hospitalar Universitário do Porto PortugalMedical Oncology Department Centro Hospitalar Universitário do Porto PortugalMedical Oncology Department Centro Hospitalar Universitário do Porto PortugalMedical Oncology Department Centro Hospitalar Universitário do Porto PortugalMedical Oncology Department Centro Hospitalar Universitário do Porto PortugalMedical Oncology Department Centro Hospitalar Universitário do Porto PortugalAbstract Chemotherapy (CT) and immunotherapy (IO) act synergically in the treatment of non‐small cell lung cancer (NSCLC). However, the molecular basis of such interaction is poorly understood. The aim of this review was to explore the mechanisms of CT to potentiate the immune system and, consequently, the action of IO. The most up‐to‐date knowledge concerning the interaction of CT and IO in NSCLC was reviewed and a bibliographic search was made in PubMed/Medline database, using the mentioned keywords, with preference given to recently published articles in English. In addition to the direct cytotoxic effect, CT affects the immune system leading indirectly to cell death. The immune response triggered by PD‐1 inhibition is enhanced by the cytotoxic immunogenic effects of CT. This potentiation phenomenon occurs due to an increase in effector cells relatively to regulatory cells, inhibition of myeloid derived suppressor cells, increased potential for cross‐presentation by dendritic cells after the death of tumor cells or blocking the STAT6 pathway to increase dendritic cell activity. In conclusion, the effects of CT on the immune system work in synergy with the actions of IO, transforming “cold” tumors into “hot” tumors, which are more visible to the immune system.https://doi.org/10.1111/1759-7714.14779chemotherapyimmunotherapynon‐small cell lung cancer |
| spellingShingle | Ana Sofia Mendes Raquel Romão Joana Febra Sérgio Xavier Azevedo Paula Fidalgo António Araújo Chemotherapy: A partnership with immunotherapy in non‐small cell lung cancer Thoracic Cancer chemotherapy immunotherapy non‐small cell lung cancer |
| title | Chemotherapy: A partnership with immunotherapy in non‐small cell lung cancer |
| title_full | Chemotherapy: A partnership with immunotherapy in non‐small cell lung cancer |
| title_fullStr | Chemotherapy: A partnership with immunotherapy in non‐small cell lung cancer |
| title_full_unstemmed | Chemotherapy: A partnership with immunotherapy in non‐small cell lung cancer |
| title_short | Chemotherapy: A partnership with immunotherapy in non‐small cell lung cancer |
| title_sort | chemotherapy a partnership with immunotherapy in non small cell lung cancer |
| topic | chemotherapy immunotherapy non‐small cell lung cancer |
| url | https://doi.org/10.1111/1759-7714.14779 |
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