The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI

The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI

The connection between signaling pathways activating cancer-associated fibroblasts (CAFs) remains to be determined. Metabolic alterations linked to autophagy have also been implicated in CAF activation. CSL/RBPJ, a transcriptional repressor that mediates Notch signaling, suppresses the gene expressi...

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Bibliographic Details
Main Authors: Sandro Goruppi, Maria-Giuseppina Procopio, Seunghee Jo, Andrea Clocchiatti, Victor Neel, G. Paolo Dotto
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
tumor microenvironment
cancer stroma
CAF
cancer-associated fibroblast
CSL/RBPJ
autophagy
GLI
ULK3
SCC
squamous cell carcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717311737

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