Hepatic venous pressure gradient: clinical use in chronic liver disease
Portal hypertension is a severe consequence of chronic liver diseases and is responsible for the main clinical complications of liver cirrhosis. Hepatic venous pressure gradient (HVPG) measurement is the best available method to evaluate the presence and severity of portal hypertension. Clinically s...
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| Format: | Article |
| Language: | English |
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Korean Association for the Study of the Liver
2014-03-01
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| Series: | Clinical and Molecular Hepatology |
| Subjects: | |
| Online Access: | http://e-cmh.org/upload/pdf/cmh-20-6.pdf |
| _version_ | 1828815190440804352 |
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| author | Ki Tae Suk |
| author_facet | Ki Tae Suk |
| author_sort | Ki Tae Suk |
| collection | DOAJ |
| description | Portal hypertension is a severe consequence of chronic liver diseases and is responsible for the main clinical complications of liver cirrhosis. Hepatic venous pressure gradient (HVPG) measurement is the best available method to evaluate the presence and severity of portal hypertension. Clinically significant portal hypertension is defined as an increase in HVPG to >10 mmHg. In this condition, the complications of portal hypertension might begin to appear. HVPG measurement is increasingly used in the clinical fields, and the HVPG is a robust surrogate marker in many clinical applications such as diagnosis, risk stratification, identification of patients with hepatocellular carcinoma who are candidates for liver resection, monitoring of the efficacy of medical treatment, and assessment of progression of portal hypertension. Patients who had a reduction in HVPG of ≥20% or to ≤12 mmHg in response to drug therapy are defined as responders. Responders have a markedly decreased risk of bleeding/rebleeding, ascites, and spontaneous bacterial peritonitis, which results in improved survival. This review provides clinical use of HVPG measurement in the field of liver disease. |
| first_indexed | 2024-12-12T10:38:46Z |
| format | Article |
| id | doaj.art-c9699d3821e94869aa9917287c7ba31f |
| institution | Directory Open Access Journal |
| issn | 2287-2728 2287-285X |
| language | English |
| last_indexed | 2024-12-12T10:38:46Z |
| publishDate | 2014-03-01 |
| publisher | Korean Association for the Study of the Liver |
| record_format | Article |
| series | Clinical and Molecular Hepatology |
| spelling | doaj.art-c9699d3821e94869aa9917287c7ba31f2022-12-22T00:27:07ZengKorean Association for the Study of the LiverClinical and Molecular Hepatology2287-27282287-285X2014-03-0120161410.3350/cmh.2014.20.1.61116Hepatic venous pressure gradient: clinical use in chronic liver diseaseKi Tae Suk0Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea.Portal hypertension is a severe consequence of chronic liver diseases and is responsible for the main clinical complications of liver cirrhosis. Hepatic venous pressure gradient (HVPG) measurement is the best available method to evaluate the presence and severity of portal hypertension. Clinically significant portal hypertension is defined as an increase in HVPG to >10 mmHg. In this condition, the complications of portal hypertension might begin to appear. HVPG measurement is increasingly used in the clinical fields, and the HVPG is a robust surrogate marker in many clinical applications such as diagnosis, risk stratification, identification of patients with hepatocellular carcinoma who are candidates for liver resection, monitoring of the efficacy of medical treatment, and assessment of progression of portal hypertension. Patients who had a reduction in HVPG of ≥20% or to ≤12 mmHg in response to drug therapy are defined as responders. Responders have a markedly decreased risk of bleeding/rebleeding, ascites, and spontaneous bacterial peritonitis, which results in improved survival. This review provides clinical use of HVPG measurement in the field of liver disease.http://e-cmh.org/upload/pdf/cmh-20-6.pdfPortal PressureLiver DiseasesHypertensionPortal |
| spellingShingle | Ki Tae Suk Hepatic venous pressure gradient: clinical use in chronic liver disease Clinical and Molecular Hepatology Portal Pressure Liver Diseases Hypertension Portal |
| title | Hepatic venous pressure gradient: clinical use in chronic liver disease |
| title_full | Hepatic venous pressure gradient: clinical use in chronic liver disease |
| title_fullStr | Hepatic venous pressure gradient: clinical use in chronic liver disease |
| title_full_unstemmed | Hepatic venous pressure gradient: clinical use in chronic liver disease |
| title_short | Hepatic venous pressure gradient: clinical use in chronic liver disease |
| title_sort | hepatic venous pressure gradient clinical use in chronic liver disease |
| topic | Portal Pressure Liver Diseases Hypertension Portal |
| url | http://e-cmh.org/upload/pdf/cmh-20-6.pdf |
| work_keys_str_mv | AT kitaesuk hepaticvenouspressuregradientclinicaluseinchronicliverdisease |