Association between MPO-463G > A polymorphism and chronic kidney disease: a meta-analysis
Background/objective: Previous studies have shown that MPO -463G > A (rs2333227) might be associated with chronic kidney disease (CKD) susceptibility, but sample sizes of those studies are relatively small. Hence, we decided to perform a meta-analysis to evaluate the association. Methods/main res...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-10-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/0886022X.2018.1499529 |
| _version_ | 1818061709701545984 |
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| author | Jiaxuan Qin Jinchun Xing Wei Li Kaiyan Zhang Zhun Wu |
| author_facet | Jiaxuan Qin Jinchun Xing Wei Li Kaiyan Zhang Zhun Wu |
| author_sort | Jiaxuan Qin |
| collection | DOAJ |
| description | Background/objective: Previous studies have shown that MPO -463G > A (rs2333227) might be associated with chronic kidney disease (CKD) susceptibility, but sample sizes of those studies are relatively small. Hence, we decided to perform a meta-analysis to evaluate the association. Methods/main results: Two investigators search databases systematically and independently. Odds ratios and 95% confidence intervals were used to pool the effect size. Four articles with 618 cases and 932 controls in total were included in our meta-analysis. Conclusions: MPO -463G > A was not associated with CKD susceptibility in recessive model and homozygote comparison. MPO -463G > A was associated with increased risk of CKD in allelic comparison, heterozygote comparison and dominant model, however, the results lacked stability. Owing to insufficient data, the association between MPO -463G > A and CKD cannot be fully confirmed. |
| first_indexed | 2024-12-10T13:52:38Z |
| format | Article |
| id | doaj.art-c96d5e91b4484984a29bba8dcaf51783 |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-12-10T13:52:38Z |
| publishDate | 2018-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-c96d5e91b4484984a29bba8dcaf517832022-12-22T01:46:08ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492018-10-0140154154610.1080/0886022X.2018.14995291499529Association between MPO-463G > A polymorphism and chronic kidney disease: a meta-analysisJiaxuan Qin0Jinchun Xing1Wei Li2Kaiyan Zhang3Zhun Wu4The First Affiliated Hospital of Xiamen UniversityThe First Affiliated Hospital of Xiamen UniversityThe First Affiliated Hospital of Xiamen UniversityThe First Affiliated Hospital of Xiamen UniversityThe First Affiliated Hospital of Xiamen UniversityBackground/objective: Previous studies have shown that MPO -463G > A (rs2333227) might be associated with chronic kidney disease (CKD) susceptibility, but sample sizes of those studies are relatively small. Hence, we decided to perform a meta-analysis to evaluate the association. Methods/main results: Two investigators search databases systematically and independently. Odds ratios and 95% confidence intervals were used to pool the effect size. Four articles with 618 cases and 932 controls in total were included in our meta-analysis. Conclusions: MPO -463G > A was not associated with CKD susceptibility in recessive model and homozygote comparison. MPO -463G > A was associated with increased risk of CKD in allelic comparison, heterozygote comparison and dominant model, however, the results lacked stability. Owing to insufficient data, the association between MPO -463G > A and CKD cannot be fully confirmed.http://dx.doi.org/10.1080/0886022X.2018.1499529Myeloperoxidasesingle nucleotide polymorphismrs2333227chronic kidney diseasemeta-analysis |
| spellingShingle | Jiaxuan Qin Jinchun Xing Wei Li Kaiyan Zhang Zhun Wu Association between MPO-463G > A polymorphism and chronic kidney disease: a meta-analysis Renal Failure Myeloperoxidase single nucleotide polymorphism rs2333227 chronic kidney disease meta-analysis |
| title | Association between MPO-463G > A polymorphism and chronic kidney disease: a meta-analysis |
| title_full | Association between MPO-463G > A polymorphism and chronic kidney disease: a meta-analysis |
| title_fullStr | Association between MPO-463G > A polymorphism and chronic kidney disease: a meta-analysis |
| title_full_unstemmed | Association between MPO-463G > A polymorphism and chronic kidney disease: a meta-analysis |
| title_short | Association between MPO-463G > A polymorphism and chronic kidney disease: a meta-analysis |
| title_sort | association between mpo 463g a polymorphism and chronic kidney disease a meta analysis |
| topic | Myeloperoxidase single nucleotide polymorphism rs2333227 chronic kidney disease meta-analysis |
| url | http://dx.doi.org/10.1080/0886022X.2018.1499529 |
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