Translational Relevance of Mouse Models of Atopic Dermatitis
The complexity of atopic dermatitis (AD) continues to present a challenge in the appropriate selection of a mouse model because no single murine model completely recapitulates all aspects of human AD. This has been further complicated by recent evidence of the distinct AD endotypes that are dictated...
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| Format: | Article |
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MDPI AG
2021-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/4/613 |
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| author | Justin Choi Nishadh Sutaria Youkyung Sophie Roh Zachary Bordeaux Martin P. Alphonse Shawn G. Kwatra Madan M. Kwatra |
| author_facet | Justin Choi Nishadh Sutaria Youkyung Sophie Roh Zachary Bordeaux Martin P. Alphonse Shawn G. Kwatra Madan M. Kwatra |
| author_sort | Justin Choi |
| collection | DOAJ |
| description | The complexity of atopic dermatitis (AD) continues to present a challenge in the appropriate selection of a mouse model because no single murine model completely recapitulates all aspects of human AD. This has been further complicated by recent evidence of the distinct AD endotypes that are dictated by unique patterns of inflammation involving Th1, Th2, Th17, and Th22 axes. A review of currently used mouse models demonstrates that while all AD mouse models consistently exhibit Th2 inflammation, only some demonstrate concomitant Th17 and/or Th22 induction. As the current understanding of the pathogenic contributions of these unique endotypes and their potential therapeutic roles expands, ongoing efforts to maximize a given mouse model’s homology with human AD necessitates a close evaluation of its distinct immunological signature. |
| first_indexed | 2024-03-09T05:25:38Z |
| format | Article |
| id | doaj.art-c9751e8f14084d90bd21b1dd480015a9 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T05:25:38Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-c9751e8f14084d90bd21b1dd480015a92023-12-03T12:37:12ZengMDPI AGJournal of Clinical Medicine2077-03832021-02-0110461310.3390/jcm10040613Translational Relevance of Mouse Models of Atopic DermatitisJustin Choi0Nishadh Sutaria1Youkyung Sophie Roh2Zachary Bordeaux3Martin P. Alphonse4Shawn G. Kwatra5Madan M. Kwatra6Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USADepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USADepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USADepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USADepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USADepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USADepartment of Anesthesiology, Duke University School of Medicine, Durham, NC 27710, USAThe complexity of atopic dermatitis (AD) continues to present a challenge in the appropriate selection of a mouse model because no single murine model completely recapitulates all aspects of human AD. This has been further complicated by recent evidence of the distinct AD endotypes that are dictated by unique patterns of inflammation involving Th1, Th2, Th17, and Th22 axes. A review of currently used mouse models demonstrates that while all AD mouse models consistently exhibit Th2 inflammation, only some demonstrate concomitant Th17 and/or Th22 induction. As the current understanding of the pathogenic contributions of these unique endotypes and their potential therapeutic roles expands, ongoing efforts to maximize a given mouse model’s homology with human AD necessitates a close evaluation of its distinct immunological signature.https://www.mdpi.com/2077-0383/10/4/613atopic dermatitiseczemamouse modelsdermatologyimmunology |
| spellingShingle | Justin Choi Nishadh Sutaria Youkyung Sophie Roh Zachary Bordeaux Martin P. Alphonse Shawn G. Kwatra Madan M. Kwatra Translational Relevance of Mouse Models of Atopic Dermatitis Journal of Clinical Medicine atopic dermatitis eczema mouse models dermatology immunology |
| title | Translational Relevance of Mouse Models of Atopic Dermatitis |
| title_full | Translational Relevance of Mouse Models of Atopic Dermatitis |
| title_fullStr | Translational Relevance of Mouse Models of Atopic Dermatitis |
| title_full_unstemmed | Translational Relevance of Mouse Models of Atopic Dermatitis |
| title_short | Translational Relevance of Mouse Models of Atopic Dermatitis |
| title_sort | translational relevance of mouse models of atopic dermatitis |
| topic | atopic dermatitis eczema mouse models dermatology immunology |
| url | https://www.mdpi.com/2077-0383/10/4/613 |
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