Quality of life of patients with solid malignancies at 3 months after unplanned admission in the intensive care unit: A prospective case-control study.
<h4>Background</h4>Although short- and long-term survival in critically ill patients with cancer has been described, data on their quality of life (QoL) after an intensive care unit (ICU) stay are scarce. This study aimed to determine the impact of an ICU stay on QoL assessed at 3 months...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0280027 |
| _version_ | 1827985657134317568 |
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| author | Anne-Claire Toffart Wassila M'Sallaoui Sophie Jerusalem Alexandre Godon Francois Bettega Gael Roth Julien Pavillet Edouard Girard Louis Marie Galerneau Juliette Piot Carole Schwebel Jean Francois Payen |
| author_facet | Anne-Claire Toffart Wassila M'Sallaoui Sophie Jerusalem Alexandre Godon Francois Bettega Gael Roth Julien Pavillet Edouard Girard Louis Marie Galerneau Juliette Piot Carole Schwebel Jean Francois Payen |
| author_sort | Anne-Claire Toffart |
| collection | DOAJ |
| description | <h4>Background</h4>Although short- and long-term survival in critically ill patients with cancer has been described, data on their quality of life (QoL) after an intensive care unit (ICU) stay are scarce. This study aimed to determine the impact of an ICU stay on QoL assessed at 3 months in patients with solid malignancies.<h4>Methods</h4>A prospective case-control study was conducted in three French ICUs between February 2020 and February 2021. Adult patients with lung, colorectal, or head and neck cancer who were admitted in the ICU were matched in a 1:2 ratio with patients who were not admitted in the ICU regarding their type of cancer, curative or palliative anticancer treatment, and treatment line. The primary endpoint was the QoL assessed at 3 months from inclusion using the mental and physical components of the Short Form 36 (SF-36) Health Survey. The use of anticancer therapies at 3 months was also evaluated.<h4>Results</h4>In total, 23 surviving ICU cancer patients were matched with 46 non-ICU cancer patients. Four patients in the ICU group did not respond to the questionnaire. The mental component score of the SF-36 was higher in ICU patients than in non-ICU patients: median of 54 (interquartile range: 42-57) vs. 47 (37-52), respectively (p = 0.01). The physical component score of the SF-36 did not differ between groups: 35 (31-47) vs. 42 (34-47) (p = 0.24). In multivariate analysis, no association was found between patient QoL and an ICU stay. A good performance status and a non-metastatic cancer at baseline were independently associated with a higher physical component score. The use of anticancer therapies at 3 months was comparable between the two groups.<h4>Conclusion</h4>In patients with solid malignancies, an ICU stay had no negative impact on QoL at 3 months after discharge when compared with matched non-ICU patients. |
| first_indexed | 2024-04-09T23:17:55Z |
| format | Article |
| id | doaj.art-c97530a889434f4e9d053c014dfdb53f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-09T23:17:55Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c97530a889434f4e9d053c014dfdb53f2023-03-22T05:31:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01181e028002710.1371/journal.pone.0280027Quality of life of patients with solid malignancies at 3 months after unplanned admission in the intensive care unit: A prospective case-control study.Anne-Claire ToffartWassila M'SallaouiSophie JerusalemAlexandre GodonFrancois BettegaGael RothJulien PavilletEdouard GirardLouis Marie GalerneauJuliette PiotCarole SchwebelJean Francois Payen<h4>Background</h4>Although short- and long-term survival in critically ill patients with cancer has been described, data on their quality of life (QoL) after an intensive care unit (ICU) stay are scarce. This study aimed to determine the impact of an ICU stay on QoL assessed at 3 months in patients with solid malignancies.<h4>Methods</h4>A prospective case-control study was conducted in three French ICUs between February 2020 and February 2021. Adult patients with lung, colorectal, or head and neck cancer who were admitted in the ICU were matched in a 1:2 ratio with patients who were not admitted in the ICU regarding their type of cancer, curative or palliative anticancer treatment, and treatment line. The primary endpoint was the QoL assessed at 3 months from inclusion using the mental and physical components of the Short Form 36 (SF-36) Health Survey. The use of anticancer therapies at 3 months was also evaluated.<h4>Results</h4>In total, 23 surviving ICU cancer patients were matched with 46 non-ICU cancer patients. Four patients in the ICU group did not respond to the questionnaire. The mental component score of the SF-36 was higher in ICU patients than in non-ICU patients: median of 54 (interquartile range: 42-57) vs. 47 (37-52), respectively (p = 0.01). The physical component score of the SF-36 did not differ between groups: 35 (31-47) vs. 42 (34-47) (p = 0.24). In multivariate analysis, no association was found between patient QoL and an ICU stay. A good performance status and a non-metastatic cancer at baseline were independently associated with a higher physical component score. The use of anticancer therapies at 3 months was comparable between the two groups.<h4>Conclusion</h4>In patients with solid malignancies, an ICU stay had no negative impact on QoL at 3 months after discharge when compared with matched non-ICU patients.https://doi.org/10.1371/journal.pone.0280027 |
| spellingShingle | Anne-Claire Toffart Wassila M'Sallaoui Sophie Jerusalem Alexandre Godon Francois Bettega Gael Roth Julien Pavillet Edouard Girard Louis Marie Galerneau Juliette Piot Carole Schwebel Jean Francois Payen Quality of life of patients with solid malignancies at 3 months after unplanned admission in the intensive care unit: A prospective case-control study. PLoS ONE |
| title | Quality of life of patients with solid malignancies at 3 months after unplanned admission in the intensive care unit: A prospective case-control study. |
| title_full | Quality of life of patients with solid malignancies at 3 months after unplanned admission in the intensive care unit: A prospective case-control study. |
| title_fullStr | Quality of life of patients with solid malignancies at 3 months after unplanned admission in the intensive care unit: A prospective case-control study. |
| title_full_unstemmed | Quality of life of patients with solid malignancies at 3 months after unplanned admission in the intensive care unit: A prospective case-control study. |
| title_short | Quality of life of patients with solid malignancies at 3 months after unplanned admission in the intensive care unit: A prospective case-control study. |
| title_sort | quality of life of patients with solid malignancies at 3 months after unplanned admission in the intensive care unit a prospective case control study |
| url | https://doi.org/10.1371/journal.pone.0280027 |
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