BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolism
The rising prevalence of nonalcoholic fatty liver disease (NAFLD) has become a global health threat that needs to be addressed urgently. Basic leucine zipper ATF-like transcription factor (BATF) is commonly thought to be involved in immunity, but its effect on lipid metabolism is not clear. Here, we...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2023-09-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/88521 |
| _version_ | 1797683764518715392 |
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| author | Zhiwang Zhang Qichao Liao Tingli Pan Lin Yu Zupeng Luo Songtao Su Shi Liu Menglong Hou Yixing Li Turtushikh Damba Yunxiao Liang Lei Zhou |
| author_facet | Zhiwang Zhang Qichao Liao Tingli Pan Lin Yu Zupeng Luo Songtao Su Shi Liu Menglong Hou Yixing Li Turtushikh Damba Yunxiao Liang Lei Zhou |
| author_sort | Zhiwang Zhang |
| collection | DOAJ |
| description | The rising prevalence of nonalcoholic fatty liver disease (NAFLD) has become a global health threat that needs to be addressed urgently. Basic leucine zipper ATF-like transcription factor (BATF) is commonly thought to be involved in immunity, but its effect on lipid metabolism is not clear. Here, we investigated the function of BATF in hepatic lipid metabolism. BATF alleviated high-fat diet (HFD)-induced hepatic steatosis and inhibited elevated programmed cell death protein (PD)1 expression induced by HFD. A mechanistic study confirmed that BATF regulated fat accumulation by inhibiting PD1 expression and promoting energy metabolism. PD1 antibodies alleviated hepatic lipid deposition. In conclusion, we identified the regulatory role of BATF in hepatic lipid metabolism and that PD1 is a target for alleviation of NAFLD. This study provides new insights into the relationship between BATF, PD1, and NAFLD. |
| first_indexed | 2024-03-12T00:20:34Z |
| format | Article |
| id | doaj.art-c9789a99426341c5a7b84a3476f1e585 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-03-12T00:20:34Z |
| publishDate | 2023-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-c9789a99426341c5a7b84a3476f1e5852023-09-15T13:45:36ZengeLife Sciences Publications LtdeLife2050-084X2023-09-011210.7554/eLife.88521BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolismZhiwang Zhang0Qichao Liao1Tingli Pan2Lin Yu3Zupeng Luo4Songtao Su5Shi Liu6Menglong Hou7Yixing Li8Turtushikh Damba9Yunxiao Liang10Lei Zhou11https://orcid.org/0000-0002-7145-4953Institute of Digestive Disease, Guangxi Academy of Medical Sciences, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaInstitute of Digestive Disease, Guangxi Academy of Medical Sciences, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaInstitute of Digestive Disease, Guangxi Academy of Medical Sciences, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaInstitute of Digestive Disease, Guangxi Academy of Medical Sciences, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaInstitute of Digestive Disease, Guangxi Academy of Medical Sciences, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaInstitute of Digestive Disease, Guangxi Academy of Medical Sciences, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaInstitute of Digestive Disease, Guangxi Academy of Medical Sciences, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaInstitute of Digestive Disease, Guangxi Academy of Medical Sciences, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaCollege of Animal Science and Technology, Guangxi University, Nanning, ChinaSchool of Pharmacy, Mongolian National University of Medical Sciences, Ulan Bator, MongoliaInstitute of Digestive Disease, Guangxi Academy of Medical Sciences, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaInstitute of Digestive Disease, Guangxi Academy of Medical Sciences, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaThe rising prevalence of nonalcoholic fatty liver disease (NAFLD) has become a global health threat that needs to be addressed urgently. Basic leucine zipper ATF-like transcription factor (BATF) is commonly thought to be involved in immunity, but its effect on lipid metabolism is not clear. Here, we investigated the function of BATF in hepatic lipid metabolism. BATF alleviated high-fat diet (HFD)-induced hepatic steatosis and inhibited elevated programmed cell death protein (PD)1 expression induced by HFD. A mechanistic study confirmed that BATF regulated fat accumulation by inhibiting PD1 expression and promoting energy metabolism. PD1 antibodies alleviated hepatic lipid deposition. In conclusion, we identified the regulatory role of BATF in hepatic lipid metabolism and that PD1 is a target for alleviation of NAFLD. This study provides new insights into the relationship between BATF, PD1, and NAFLD.https://elifesciences.org/articles/88521NAFLDBATFPD1immune |
| spellingShingle | Zhiwang Zhang Qichao Liao Tingli Pan Lin Yu Zupeng Luo Songtao Su Shi Liu Menglong Hou Yixing Li Turtushikh Damba Yunxiao Liang Lei Zhou BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolism eLife NAFLD BATF PD1 immune |
| title | BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolism |
| title_full | BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolism |
| title_fullStr | BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolism |
| title_full_unstemmed | BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolism |
| title_short | BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolism |
| title_sort | batf relieves hepatic steatosis by inhibiting pd1 and promoting energy metabolism |
| topic | NAFLD BATF PD1 immune |
| url | https://elifesciences.org/articles/88521 |
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