Vitamin D Status and Vitamin D-Dependent Apoptosis in Obesity
The role of vitamin D in obesity appears to be linked to vitamin D insufficient/deficient status. However, mechanistic understanding of the role of vitamin D in obesity is lacking. We have shown earlier that the vitamin D hormonal form, 1,25-dihydroxyvitamin D<sub>3</sub> (1,25(OH)<su...
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MDPI AG
2020-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/5/1392 |
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| author | Igor N. Sergeev |
| author_facet | Igor N. Sergeev |
| author_sort | Igor N. Sergeev |
| collection | DOAJ |
| description | The role of vitamin D in obesity appears to be linked to vitamin D insufficient/deficient status. However, mechanistic understanding of the role of vitamin D in obesity is lacking. We have shown earlier that the vitamin D hormonal form, 1,25-dihydroxyvitamin D<sub>3</sub> (1,25(OH)<sub>2</sub>D<sub>3</sub>), induces cell death by apoptosis in mature adipocytes. This effect of the hormone is mediated by the cellular Ca<sup>2+</sup> signaling pathway: a sustained increase of intracellular (cytosolic) Ca<sup>2+</sup> concentration followed by activation of Ca<sup>2+</sup>-dependent initiators and effectors of apoptosis. In recent animal studies, we demonstrated that low vitamin D status is observed in diet-induced obesity (DIO). High intake of vitamin D<sub>3</sub> in DIO decreased the weight of white adipose tissue and improved biomarkers related to adiposity and Ca<sup>2+</sup> regulation. The anti-obesity effect of vitamin D (1,25(OH)<sub>2</sub>D<sub>3</sub>) in DIO was determined by the induction of Ca<sup>2+</sup>-mediated apoptosis in mature adipocytes executed by Ca<sup>2+</sup>-dependent apoptotic proteases (calpains and caspases). Thus, a high intake of vitamin D in obesity increases vitamin D nutritional status and normalizes vitamin D hormonal status that is accompanied by the reduction of adiposity. Overall, our findings imply that vitamin D may contribute to the prevention of obesity and obesity-related diseases and that the mechanism of the anti-obesity effect of 1,25(OH)<sub>2</sub>D<sub>3</sub> includes induction of Ca<sup>2+</sup>-mediated apoptosis in adipocytes. |
| first_indexed | 2024-03-10T19:52:56Z |
| format | Article |
| id | doaj.art-c979f38fdd4447a5a030c818e0711024 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T19:52:56Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-c979f38fdd4447a5a030c818e07110242023-11-20T00:15:10ZengMDPI AGNutrients2072-66432020-05-01125139210.3390/nu12051392Vitamin D Status and Vitamin D-Dependent Apoptosis in ObesityIgor N. Sergeev0Department of Health and Nutritional Sciences, South Dakota State University, Brookings, SD 57007, USAThe role of vitamin D in obesity appears to be linked to vitamin D insufficient/deficient status. However, mechanistic understanding of the role of vitamin D in obesity is lacking. We have shown earlier that the vitamin D hormonal form, 1,25-dihydroxyvitamin D<sub>3</sub> (1,25(OH)<sub>2</sub>D<sub>3</sub>), induces cell death by apoptosis in mature adipocytes. This effect of the hormone is mediated by the cellular Ca<sup>2+</sup> signaling pathway: a sustained increase of intracellular (cytosolic) Ca<sup>2+</sup> concentration followed by activation of Ca<sup>2+</sup>-dependent initiators and effectors of apoptosis. In recent animal studies, we demonstrated that low vitamin D status is observed in diet-induced obesity (DIO). High intake of vitamin D<sub>3</sub> in DIO decreased the weight of white adipose tissue and improved biomarkers related to adiposity and Ca<sup>2+</sup> regulation. The anti-obesity effect of vitamin D (1,25(OH)<sub>2</sub>D<sub>3</sub>) in DIO was determined by the induction of Ca<sup>2+</sup>-mediated apoptosis in mature adipocytes executed by Ca<sup>2+</sup>-dependent apoptotic proteases (calpains and caspases). Thus, a high intake of vitamin D in obesity increases vitamin D nutritional status and normalizes vitamin D hormonal status that is accompanied by the reduction of adiposity. Overall, our findings imply that vitamin D may contribute to the prevention of obesity and obesity-related diseases and that the mechanism of the anti-obesity effect of 1,25(OH)<sub>2</sub>D<sub>3</sub> includes induction of Ca<sup>2+</sup>-mediated apoptosis in adipocytes.https://www.mdpi.com/2072-6643/12/5/13921,25-dihydroxyvitamin D<sub>3</sub>apoptosisadipocytesintracellular Ca<sup>2+</sup>obesityvitamin D status |
| spellingShingle | Igor N. Sergeev Vitamin D Status and Vitamin D-Dependent Apoptosis in Obesity Nutrients 1,25-dihydroxyvitamin D<sub>3</sub> apoptosis adipocytes intracellular Ca<sup>2+</sup> obesity vitamin D status |
| title | Vitamin D Status and Vitamin D-Dependent Apoptosis in Obesity |
| title_full | Vitamin D Status and Vitamin D-Dependent Apoptosis in Obesity |
| title_fullStr | Vitamin D Status and Vitamin D-Dependent Apoptosis in Obesity |
| title_full_unstemmed | Vitamin D Status and Vitamin D-Dependent Apoptosis in Obesity |
| title_short | Vitamin D Status and Vitamin D-Dependent Apoptosis in Obesity |
| title_sort | vitamin d status and vitamin d dependent apoptosis in obesity |
| topic | 1,25-dihydroxyvitamin D<sub>3</sub> apoptosis adipocytes intracellular Ca<sup>2+</sup> obesity vitamin D status |
| url | https://www.mdpi.com/2072-6643/12/5/1392 |
| work_keys_str_mv | AT igornsergeev vitamindstatusandvitaminddependentapoptosisinobesity |